Studying of the 9Be Structure

Experimental data on inelasti

Phenotype characteristic of colonic intraepithelial lymphocytes in patients with Crohn's disease

Intraepithelial lymphocytes (IEL) play a critical role in maintaining the immune balance of the gut and provide the first line of mucosal defense against luminal antigens as well as rapidly respond to epithelial injury. Recently, IEL have received a lot of attention as key mediators of aberrant immune response resulted in persistent immune activation, inflammation and altered intestinal barrier function, seen in Crohn's disease (CD). This study describes for the first time subsets of colonic IEL in CD patients as compared to healthy controls aimed at characterization of altered IEL contribution to the pathogenesis of Crohn's disease.The peripheral venous blood and colon tissues were obtained from 10 CD patients and 6 donors. IEL were isolated from the mucosa by incubation the tissue in a predigesting solution. Lymphoid cells phenotype was investigated using monoclonal antibodies and flow cytometry.The majority of colonic IEL was identified as СD3+T lymphocytes and no significant differences were found in their numbers in investigated groups. However, changes in T cell subsets composition have been shown: the ratio of СD3+СD4+IEL and СD3+СD8+IEL was 1:1 in colon of CD patients and correlated with T cells in peripheral blood (R = 0.7; p < 0.05) while donor tissues were characterized by expected СD3+СD8+T killers prevalence and the ratio reached 1:2 (p < 0.05). The increase of unconventional γδIEL (mainly due to V81+T cells) and СD161+T cells in association with TNK cells decrease were revealed in colon (p < 0.01) as well as in peripheral blood (p < 0.05) of CD patients as compared to donors. Moreover, the number of colonic γδIEL was correlated with disease location (R = -0.6; p < 0.05), and disease behavior (R = 0.7; p < 0.01) according to Montreal classification.The observed data indicates changes in colonic IEL composition in CD patients that may provide valuable insight into the contribution of T helpers, γδT cells and mucosa-associated СD161+T cells in autoimmune intestinal inflammation but need further possible mechanisms discussion

Isospin triplet A=14 : search for states with enhanced radii

This article is devoted to study of isobar-Analogue states 1- in triplet A=14: 14C-14N-14O. Previously signs of neutron halo in the 1-, 6.09 MeV state of 14C were obtained by two independent groups. In this article we propose to study neighbouring nuclei 14N and 14O using the Modified diffraction model (MDM) method and the method of Asymptotic normalization coefficients (ANC). Methods were applied to experimental differential cross sections of 14C(α,α)14C scattering and reactions 13C(3He,d)14N and 14N(3He,t)14O. MDM and ANC gave practically similar within errors radii for the studied 1- states: The 6.09 MeV state in 14C-2.7 0.1 fm, the 8.06 MeV state in 14N-2.7 0.1 fm, the 5.17 MeV state in 14O-2.6 0.2 fm. Moreover, the signs of proton halo in the 1- state of 14N were obtained for the first time.peerReviewe

The study of the 12C states from the reaction 11B(3He, d)12C

The experiment was done to study 11B(3He, d)12C reaction with energy E(3He)=25 MeV. The aim of the experiment is to determine the properties of 12C states at high excitation energies and in particular to verify which of the conflicting spin-parity assignments of the 13.35 MeV state (2− or 4−) should be assigned. Behavior of the experimental angular distribution and also the DWBA calculation correspond to spin parity 4− for 13.35 MeV state.peerReviewe

Possible neutron and proton halo structure in the isobaric analog states of A=12 nuclei

The differential cross sections of the 11B(3He,d)12C reaction leading to formation of the 0+ ground state and the 15.11-MeV 1 +, 16.57-MeV 2−, and 17.23-MeV 1− excited states of 12C are measured at Elab=25 MeV. The analysis of the data is carried out within the coupled-reaction-channels method for the direct proton transfer to the bound and unbound states. The rms radii of the last proton in all states studied are determined. A comparison of the rms radii of the 12B, 12C, and 12N nuclei in the isobaric analog states (IASs) with isospin T=1 determined by different methods allows us to arrive at a conclusion that these nuclei in the 1− excited states at Ex=2.62, 17.23, and 1.80 MeV, respectively, possess one-nucleon (neutron or proton) halo structure. The enlarged radii and a large probability of the last neutron to be outside of the range of the interaction potential are also found for the 2− states of 12B, 12C, and 12N at Ex=1.67, 16.57, and 1.19 MeV, respectively. These IASs also can be regarded as candidates for states with one-nucleon (neutron or proton) halo.peerReviewe