Keeping Kids First: Trial Court Discretion and the Best Interest of the Child in Light v. D\u27Amato

Family dissolution is a difficult ordeal for everyone involved: the parties, their lawyers, and the court. After all, these are not parties engaged in an arm’s length dealing, or strangers involved in an accident. On the contrary, the parties are generally intimately involved and often share property and children. Spouses frequently struggle to agree on even the most trivial of property divisions, with the ownership of a simple rocking chair a potential issue for appeal. As contentious as such property division disputes can be, disputes between divorcing parents regarding the allocation of parental rights and responsibilities are particularly bitter. Most parents recognize, at least in the abstract, what the Maine Legislature demands: children do best when allowed to benefit from the affection and support of both parents. Nonetheless, each parent generally wants to spend as much time with his or her child as possible, and any time gained comes at the expense of the other parent

How Social Processes Distort Measurement: The Impact of Survey Nonresponse on Estimates of Volunteer Work

Estimates of volunteering in the United States vary greatly from survey to survey and do not show the decline over time common to other measures of social capital. We argue that these anomalies are caused by the social processes that determine survey participation, in particular the propensity of people who do volunteer work to respond to surveys at higher rates than those who do not do volunteer work. Thus surveys with lower responses rates will usually have higher proportions of volunteers, and the decline in response rates over time likely has led to increasing overrepresentation of volunteers. We analyze data from the American Time Use Survey (ATUS) -- the sample for which is drawn from Current Population Survey (CPS) respondents -- together with data from the CPS Volunteering Supplement to demonstrate the effects of survey nonresponse on estimates of volunteering activity and its correlates. CPS respondents who become ATUS respondents report much more volunteering in the CPS than those who become ATUS nonrespondents. This difference is replicated within demographic and other subgroups. Consequently, conventional statistical adjustments for nonresponse cannot correct the resulting bias. Although nonresponse leads to estimates of volunteer activity that are too high, it generally does not affect inferences about the characteristics associated with volunteer activity. We discuss the implications of these findings for the study of other phenomena.

The home environment : influences on the health of young-old and old-old adults in Australia

The physical and societal characteristics of home have been established as important in influencing the health and wellbeing of older adults, yet these have rarely been explored together. There is also limited research into variation across age groups, with older adults often examined as a homogenous group of those 65 years and over. This study advances the knowledge base by using the concept of person–environment (P-E) fit to analyse differences in personal and home environment (physical and societal) characteristics between young-old (65–74 years) and old-old (75 and above) age groups, and to assess how these characteristics influence their self-perceived health. This cross-sectional study draws upon survey data from 1,999 older adult participants from the Australian Housing Conditions Dataset. Descriptive statistics and inferential analysis were used to assess for significant differences between age groups and a binomial logistic regression was utilised to examine influences on health. The analysis found that the factors which influence health varies appreciably between age groups. For the young-old financial strain, being on the fixed-income pension and hypertension were important contributing factors, in contrast for the old-old gender (being male), having depression and the home being modified for disability were key influences. For both age groups heart disease was a contributing factor to perceived health. The results indicate the important contribution to knowledge of incorporating a wide range of person and environment characteristics when exploring P-E fit for older adults. The inclusion of societal aspects, such as financial strain, fixed-income pension, tenure and access to community aged care services when exploring influences on health, arises as a key conclusion of the study. In terms of impact, this research is significant given rising inequalities globally and specifically in the Australian context, the need for policy measures to address income inequality, and its health and social implications for older households.https://www.cambridge.org/core/journals/ageing-and-societyFinancial Managemen

Tuning of Collagen Scaffold Properties Modulates Embedded Endothelial Cell Regulatory Phenotype in Repair of Vascular Injuries In Vivo

Perivascularly implanted matrix embedded endothelial cells (MEECs) are potent regulators of inflammation and intimal hyperplasia following vascular injuries. Endothelial cells (ECs) in collagen scaffolds adopt a reparative phenotype with significant therapeutic potential. Although the biology of MEECs is increasingly understood, tuning of scaffold properties to control cell-substrate interactions is less well-studied. It is hypothesized that modulating scaffold degradation would change EC phenotype. Scaffolds with differential degradation are prepared by cross-linking and predegradation. Vascular injury increases degradation and the presence of MEECs retards injury-mediated degradation. MEECs respond to differential scaffold properties with altered viability in vivo, suppressed smooth muscle cell (SMC) proliferation in vitro, and altered interleukin-6 and matrix metalloproteinase-9 expression. When implanted perivascularly to a murine carotid wire injury, tuned scaffolds change MEEC effects on vascular repair and inflammation. Live animal imaging enables real-time tracking of cell viability, inflammation, and scaffold degradation, affording an unprecedented understanding of interactions between cells, substrate, and tissue. MEEC-treated injuries improve endothelialization and reduce SMC hyperplasia over 14 d. These data demonstrate the potent role material design plays in tuning MEEC efficacy in vivo, with implications for the design of clinical therapies.National Institutes of Health (U.S.) (Grant R01 GM 49039

Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug

Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug more evenly within the intimal area rather than concentrating drug around the stent struts and for its ability to match coating erosion with drug release. The coating consisted of absorbable poly-lactide-co-glycolic acid (PLGA) and crystalline sirolimus deposited by a dry-powder electrostatic process. The AC-SES demonstrated enhanced drug stability under simulated use conditions and consistent drug delivery balanced with coating erosion in a porcine coronary implant model. The initial drug burst was eliminated and drug release was sustained after implantation. The coating was absorbed within 90 days. Following implantation into porcine coronary arteries the AC-SES coating is distributed in the surrounding intimal tissue over the course of several weeks. Computational modeling of drug delivery characteristics demonstrates how distributed coating optimizes the load of drug immediately around each stent strut and extends drug delivery between stent struts. The result was a highly efficient arterial uptake of drug with superior performance to a clinical bare metal stent (BMS). Neointimal thickness (0.17 ± 0.07 mm vs. 0.28 ± 0.11 mm) and area percent stenosis (22 ± 9% vs. 35 ± 12%) were significantly reduced (p < 0.05) by the AC-SES compared to the BMS 30 days after stent implantation in an overlap configuration in porcine coronary arteries. Inflammation was significantly reduced in the AC-SES compared to the BMS at both 30 and 90 days after implantation. Biocompatible, rapidly absorbable stent coatings enable the matching of drug release with coating erosion and provide for the controlled migration of coating material into tissue to reduce vicissitudes in drug tissue levels, optimizing efficacy and reducing potential toxicity.Micell Technologies, Inc.National Institutes of Health (U.S.) (R01 GM49039

Volumetric, relaxometric and diffusometric correlates of psychotic experiences in a non-clinical sample of young adults

BackgroundGrey matter (GM) abnormalities are robust features of schizophrenia and of people at ultra high-risk for psychosis. However the extent to which neuroanatomical alterations are evident in non-clinical subjects with isolated psychotic experiences is less clear.MethodsIndividuals (mean age 20 years) with (n = 123) or without (n = 125) psychotic experiences (PEs) were identified from a population-based cohort. All underwent T1-weighted structural, diffusion and quantitative T1 relaxometry MRI, to characterise GM macrostructure, microstructure and myelination respectively. Differences in quantitative GM structure were assessed using voxel-based morphometry (VBM). Binary and ordinal models of PEs were tested. Correlations between socioeconomic and other risk factors for psychosis with cortical GM measures were also computed.ResultsGM volume in the left supra-marginal gyrus was reduced in individuals with PEs relative to those with no PEs. The greater the severity of PEs, the greater the reduction in T1 relaxation rate (R1) across left temporoparietal and right pre-frontal cortices. In these regions, R1 was positively correlated with maternal education and inversely correlated with general psychopathology.ConclusionsPEs in non-clinical subjects were associated with regional reductions in grey-matter volume reduction and T1 relaxation rate. The alterations in T1 relaxation rate were also linked to the level of general psychopathology. Follow up of these subjects should clarify whether these alterations predict the later development of an ultra high-risk state or a psychotic disorder

Extraction and correlation of total phenolic and flavonoid contents in seaweeds collected from Rameshwaram during pre- and post- monsoon period using different solvent systems with their antioxidant activity

The present study was carried out to compare and correlate the phenolic and flavonoid contents of Turbinaria sp., Sargassum sp. and Gracilaria sp. extracted using different solvents including methanol, isopropyl alcohol, acetone, acetonitrile, ethyl acetate and hexane, and elucidated for their anti-oxidant activity. The total phenolic and flavonoid contents of the solvent extracts were determined using the Folin-Ciocalteau assay and aluminium chloride colorimetric assay with gallic acid and quercetin as standards, respectively. The anti-oxidant activity in phenolic and flavonoid content was also estimated by phosphomolybdenum method and was compared with gallic acid and quercetin standard. The quantitative analysis of flavonoid content reveals that methanolic extract of Sargassum sp. (9.56±0.38 mg QE/g during pre-monsoon and 9.44±0.48 mg QE/g during post-monsoon season); acetone extract of Gracilaria sp. (2.16±0.11 mg QE/g during pre-monsoon and 2.12±0.07 mg QE/g during post-monsoon season) and methanolic extract of Turbinaria sp. (4.11±0.12 mg QE/g during pre-monsoon and 4.22±0.15 mg QE/g during post-monsoon season) had higher concentration of flavonoid content. However, the quantitative analysis of phenolic content was found to be lower in all the seaweed extracts as compared to flavonoids. The anti-oxidant activity of a phenolic content and flavonoid content were also found to be correlated. The findings of the current study conclusively demonstrate the content of phenolic and flavonoid compounds significantly correlate with anti-oxidant activity

Prevention of arteriovenous shunt occlusion using microbubble and ultrasound mediated thromboprophylaxis.

BACKGROUND: Palliative shunts in congenital heart disease patients are vulnerable to thrombotic occlusion. High mechanical index (MI) impulses from a modified diagnostic ultrasound (US) transducer during a systemic microbubble (MB) infusion have been used to dissolve intravascular thrombi without anticoagulation, and we sought to determine whether this technique could be used prophylactically to reduce thrombus burden and prevent occlusion of surgically placed extracardiac shunts. METHODS AND RESULTS: Heparin-bonded ePTFE tubular vascular shunts of 4 mm×2.5 cm (Propaten; W.L Gore) were surgically placed in 18 pigs: a right-sided side-to-side arteriovenous (AV, carotid-jugular) shunt, and a left-sided arterio-arterial (AA, carotid-carotid) interposition shunt in each animal. After shunt implantation, animals were randomly assigned to one of 3 groups. Transcutaneous, weekly 30-minute treatments (total of 4 treatments) of either guided high MI US+MB (Group 1; n=6) using a 3% MRX-801 MB infusion, or US alone (Group 2; n=6) were given separately to each shunt. The third group of 6 pigs received no treatments. The shunts were explanted after 4 weeks and analyzed by histopathology to quantify luminal thrombus area (mm2) for the length of each shunt. No pigs received antiplatelet agents or anticoagulants during the treatment period. The median overall thrombus burden in the 3 groups for AV shunts was 5.10 mm2 compared with 4.05 mm(2) in AA (P=0.199). Group 1 pigs had significantly less thrombus burden in the AV shunts (median 2.5 mm2) compared with Group 2 (median 5.6 mm2) and Group 3 (median 7.5 mm2) pigs (P=0.006). No difference in thrombus burden was seen between groups for AA shunts. CONCLUSION: Transcutaneous US with intravenous MB is capable of preventing thrombus accumulation in arteriovenous shunts without the need for antiplatelet agents, and may be a method of preventing progressive occlusion of palliative shunts