Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan

Abstract: The timing of puberty is highly variable and is associated with long-term health outcomes. To date, understanding of the genetic control of puberty timing is based largely on studies in women. Here, we report a multi-trait genome-wide association study for male puberty timing with an effective sample size of 205,354 men. We find moderately strong genomic correlation in puberty timing between sexes (rg = 0.68) and identify 76 independent signals for male puberty timing. Implicated mechanisms include an unexpected link between puberty timing and natural hair colour, possibly reflecting common effects of pituitary hormones on puberty and pigmentation. Earlier male puberty timing is genetically correlated with several adverse health outcomes and Mendelian randomization analyses show a genetic association between male puberty timing and shorter lifespan. These findings highlight the relationships between puberty timing and health outcomes, and demonstrate the value of genetic studies of puberty timing in both sexes

Refining the Desert: The Politics of Wealth, Industrialization, and Environmental Risk in the Twentieth-Century Texas Oil Industry

This dissertation describes seventy years of West Texas oil expansion and decline juxtaposed against a growing environmental and public health crisis. It tracks the experiences of industry employees, demonstrating that their understanding of oil industrialization and the environmental cost of economic success was complex and historically contingent. Rather than assuming that simple greed allowed industry personnel to ignore resource depletion and environmental contamination, this dissertation argues that a workplace culture of individualistic risk-taking coupled with industry propaganda that bred a utopian faith in technology was reinforced by the region’s punishing geography, general isolation, and the limits of industrial infrastructure. This project expands the thematic and geographic scope of current energy history scholarship, using the intertwined themes of environmental, personal, and economic risk to demonstrate the cultural contingency of energy system development. Bridging the disciplines of labor, environmental, and technological history, this project demonstrates that West Texas, along with regional innovations in oil technology and science, were central to both US petroleum development and indicative of broader twentieth-century debates about government control over natural resources and the acceptable victims of industrial contamination

Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan

The timing of puberty is highly variable and is associated with long-term health outcomes. To date, understanding of the genetic control of puberty timing is based largely on studies in women. Here, we report a multi-trait genome-wide association study for male puberty timing with an effective sample size of 205,354 men. We find moderately strong genomic correlation in puberty timing between sexes (rg = 0.68) and identify 76 independent signals for male puberty timing. Implicated mechanisms include an unexpected link between puberty timing and natural hair colour, possibly reflecting common effects of pituitary hormones on puberty and pigmentation. Earlier male puberty timing is genetically correlated with several adverse health outcomes and Mendelian randomization analyses show a genetic association between male puberty timing and shorter lifespan. These findings highlight the relationships between puberty timing and health outcomes, and demonstrate the value of genetic studies of puberty timing in both sexes.</p