45 research outputs found
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Bright AGN Source List from the First Three Months of the Fermi Large Area Telescope All-Sky Survey
Mineralização de nitrogênio e enxofre em solos brasileiros sob influência da calagem e fósforo
A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry
Although men of African ancestry have a high risk of prostate cancer (PCa), no genes or mutations have been identified that contribute to familial clustering of PCa in this population. We investigated whether the African ancestry–specific PCa risk variant at 8q24, rs72725854, is enriched in men with a PCa family history in 9052 cases, 143 cases from high-risk families, and 8595 controls of African ancestry. We found the risk allele to be significantly associated with earlier age at diagnosis, more aggressive disease, and enriched in men with a PCa family history (32% of high-risk familial cases carried the variant vs 23% of cases without a family history and 12% of controls). For cases with two or more first-degree relatives with PCa who had at least one family member diagnosed at age <60 yr, the odds ratios for TA heterozygotes and TT homozygotes were 3.92 (95% confidence interval [CI] = 2.13–7.22) and 33.41 (95% CI = 10.86–102.84), respectively. Among men with a PCa family history, the absolute risk by age 60 yr reached 21% (95% CI = 17–25%) for TA heterozygotes and 38% (95% CI = 13–65%) for TT homozygotes. We estimate that in men of African ancestry, rs72725854 accounts for 32% of the total familial risk explained by all known PCa risk variants. Patient summary: We found that rs72725854, an African ancestry–specific risk variant, is more common in men with a family history of prostate cancer and in those diagnosed with prostate cancer at younger ages. Men of African ancestry may benefit from the knowledge of their carrier status for this genetic risk variant to guide decisions about prostate cancer screening. © 2020 The AuthorsThe African ancestry–specific prostate cancer risk variant at 8q24, rs72725854, is enriched in men diagnosed at younger ages and men with a prostate cancer family history. Carriers of this risk allele would benefit from regular and earlier prostate cancer screening
Thin-layer chromatography of mycobacterial lipids as an aid to classification: The Scotochromogenic Mycobacteria, including Mycobacterium scrofulaceum The scotochromonegic Mycobacteria, including mycobacterium scrofulaceum, M.xenopi, M. . xenopi, M. aquae, M. gordonae, M. flavescens
The “Supernatural Artist” and the Tarot Fool: Transnational Esotericism in W.B. Yeats’s On Baile’s Strand
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Computation applied to particle accelerator simulations
The rapid growth in the power of large-scale computers has had a revolutionary effect on the study of charged-particle accelerators that is similar to the impact of smaller computers on everyday life. Before an accelerator is built, it is now the absolute rule to simulate every component and subsystem by computer to establish modes of operation and tolerances. We will bypass the important and fruitful areas of control and operation and consider only application to design and diagnostic interpretation. Applications of computers can be divided into separate categories including: component design, system design, stability studies, cost optimization, and operating condition simulation. For the purposes of this report, we will choose a few examples taken from the above categories to illustrate the methods and we will discuss the significance of the work to the project, and also briefly discuss the accelerator project itself. The examples that will be discussed are: (1) the tracking analysis done for the main ring of the Superconducting Supercollider, which contributed to the analysis which ultimately resulted in changing the dipole coil diameter to 5 cm from the earlier design for a 4-cm coil-diameter dipole magnet; (2) the design of accelerator structures for electron-positron linear colliders and circular colliding beam systems (B-factories); (3) simulation of the wake fields from multibunch electron beams for linear colliders; and (4) particle-in-cell simulation of space-charge dominated beams for an experimental liner induction accelerator for Heavy Ion Fusion. 8 refs., 9 figs