Growing Cricket in Tasmania: A Cross-Cultural Comparison

Sports are an integral part of life in societies throughout the world. Cricket is one of Australia’s two major sports and is a significant aspect of its culture, in a fashion similar to baseball being America’s “national pastime.” Despite its isolation, Tasmania, the small island state of Australia, shares the same mania for cricket as mainland Australia. While in Tasmania for ten weeks interning with the Tasmanian Cricket Association (TCA), I studied the role of cricket in the day-to-day lives of Tasmanians, from the pervasive television, newspaper, and the radio coverage, to pick-up cricket games as a popular leisure time activity. I also looked at the structure of Tasmania\u27s cricket development program. The TCA has many programs set up to attract both the devoted cricketer, and the non-traditional, casual player -- beach cricket, disabled cricket, and street cricket, among others. This paper will also briefly compare how Australian cricket and American baseball differ from one another and how they are similar to one another

The role of the aryl hydrocarbon receptor in the development of cells with molecular and functional characteristics of breast cancer stem cells

Self-renewing, chemoresistant cancer cells that contribute to cancer metastasis and patient relapse have properties similar to those of stem cells, and have been termed "cancer stem cells" (CSCs) in the literature. The identification of signaling pathways that regulate CSC development and/or function is an important step towards understanding why patients relapse, and towards development of novel therapeutics that specifically target CSC vulnerabilities. Recent studies have identified a role for the aryl hydrocarbon receptor (AHR), an environmental carcinogen receptor implicated in cancer initiation, in normal tissue-specific stem cell self-renewal. These studies inspired the hypothesis that the AHR plays a role in CSC development. To test this hypothesis, AHR activity in Hs578T triple negative and SUM149 inflammatory breast cancer cells was modulated with AHR ligands, shRNA, or AHR-specific inhibitors and their phenotypic, genomic, and functional CSC characteristics were evaluated. Aldehyde dehydrogenase (ALDH) was used as an epithelial stem cell marker for flow cytometry. Results demonstrate that: 1) ALDHhigh cells express elevated levels of Ahr and the AHR-driven gene that encodes cytochrome p450 isoform 1b1 (Cyp1b1), 2) AHR knockdown reduces ALDH activity, 3) AHR hyper-activation significantly increases ALDH1 activity, expression of stem cell- and invasion/migration-associated genes, and accelerates cell migration, 4) a highly significant correlation between Ahr or Cyp1b1 expression (as a surrogate marker for AHR activity) and expression of the CSC- and invasion/migration-associated gene sets was seen with genomic data obtained from 79 human breast cancer cell lines and over 1850 primary human breast cancers, 5) the AHR interacts directly with the transcription factors Sox2 and Runx1, and AHR ligands increase this interaction, 6) AHR knockdown inhibits tumorsphere formation in low adherence conditions, 7) AHR inhibition blocks the rapid migration of ALDHhigh cells and reduces ALDHhigh cell chemoresistance, and 8) AHR knockdown inhibits tumor growth and reduces tumor Aldh1a1, Sox2, and Cyp1b1 expression in orthotopic xenografts. These data suggest that the AHR plays an important role in development of CSCs in a large fraction of human breast cancers and that environmental AHR ligands may exacerbate breast cancer by enhancing expression of CSC-like properties

Specific dopaminergic manipulation of the internal clock mechanism

Using non-specific dopaminergic agents, Meck (1983, 1986) and his colleagues have repeatedly demonstrated manipulations of the internal clock mechanism, while showing no other changes to the psychophysical function (DL & WF). The current study used analyses and procedures similar to those of Meck (1983) and investigated the internal clock mechanism with the specific D2 agonist, quinpirole. Two groups were trained with saline and tested with quinpirole (0.08 mg/kg). One group was naive to the drug prior to testing (DN), while the other had previous drug exposure (DE). A third group (DT) was trained with quinpirole, and tested with saline. The DN and DE groups revealed no differences in acquisition, no predicted shift in the point of subjective equality (PSE), and changes in the DL and WF, when compared over phase. The DT group acquired the task more slowly and to a lower criterion, and no differences were found in the PSE, DL, or WF, over phase. The data presented here do not support dopaminergic control over the clock component as represented in the Internal Clock Model (Church, 1989). Results are consistent with other research (Lejeune et al., 1995; Rapp & Robbins, 1976; Santi et al., 1995; Stubbs & Thomas, 1974) in suggesting that dopaminergic control of the internal clock is more complex than was once thought

The Effect of Synovial Fluid Enzymes on the Biodegradability of Collagen and Fibrin Clots

Recently there has been a great deal of interest in the use of biomaterials to stimulate wound healing. This is largely due to their ability to centralize high concentrations of compounds known to promote wound healing at a needed location. Joints present a unique challenge to using scaffolds because of the presence of enzymes in synovial fluid which are known to degrade materials that would be stable in other parts of the body. The hypothesis of this study was that atelocollagen scaffolds would have greater resistance to enzymatic degradation than scaffolds made of gelatin, fibrin and whole blood. To test this hypothesis, collagen and fibrin-based scaffolds were placed in matrix metallopeptidase-1 (MMP-1), elastase, and plasmin solutions at physiologic concentrations, and the degradation of each scaffold was measured at varying time points. The atelocollagen scaffolds had a significantly greater resistance to degradation by MMP-1, elastase and plasmin over the fibrin based scaffolds. The results suggest that atelocollagen-based scaffolds may provide some protection against premature degradation by synovial fluid enzymes over fibrin-based matrices

Age-specific incidence of A/H1N1 2009 influenza infection in England from sequential antibody prevalence data using likelihood-based estimation.

Estimating the age-specific incidence of an emerging pathogen is essential for understanding its severity and transmission dynamics. This paper describes a statistical method that uses likelihoods to estimate incidence from sequential serological data. The method requires information on seroconversion intervals and allows integration of information on the temporal distribution of cases from clinical surveillance. Among a family of candidate incidences, a likelihood function is derived by reconstructing the change in seroprevalence from seroconversion following infection and comparing it with the observed sequence of positivity among the samples. This method is applied to derive the cumulative and weekly incidence of A/H1N1 pandemic influenza in England during the second wave using sera taken between September 2009 and February 2010 in four age groups (1-4, 5-14, 15-24, 25-44 years). The highest cumulative incidence was in 5-14 year olds (59%, 95% credible interval (CI): 52%, 68%) followed by 1-4 year olds (49%, 95% CI: 38%, 61%), rates 20 and 40 times higher respectively than estimated from clinical surveillance. The method provides a more accurate and continuous measure of incidence than achieved by comparing prevalence in samples grouped by time period

Seroprevalence of influenza A(H1N1)pdm09 virus antibody, England, 2010 and 2011.

The intense influenza activity in England during the 2010-11 winter resulted from a combination of factors. Population-based seroepidemiology confirms that the third wave of influenza A(H1N1)pdm09 virus circulation was associated with a shift in age groups affected, with the highest rate of infection in young adults

Human Papillomavirus Antibody Reference Reagents for Use in Postvaccination Surveillance Serology

Suitably controlled serosurveillance surveys are essential for evaluating human papillomavirus (HPV) immunization programs. A panel of plasma samples from 18-year-old females was assembled, the majority of the samples being from recipients of the bivalent HPV vaccine. Antibody specificities were evaluated by three independent laboratories, and 3 pools that displayed no antibodies to any HPV type tested or intermediate or high levels of antibody to HPV16, HPV18, HPV31, and HPV45 were created. These pools will be useful as control reagents for HPV serology

The galaxy mass-size relation in CARLA clusters and proto-clusters at 1.4 < z < 2.8: larger cluster galaxy sizes

(Abridged) We study the galaxy mass-size relation in CARLA spectroscopically confirmed clusters at $1.4<z<2.8$, which span a total stellar mass $11.3<\mathrm{log}(M^c_*/M_{\odot})<12.6$ (halo mass $13.5 \lesssim \mathrm{log}(M^c_h/M_{\odot}) \lesssim 14.5$). Our main finding is that cluster passive ETG at $z \gtrsim 1.5$ with ${\rm log}(M/M_{\odot})>10.5$ are systematically $\gtrsim 0.2-0.3~{\rm dex}$ larger than field ETGs. The passive ETG average size evolution is slower at $1<z<2$ when compared to the field. This could be explained by differences in the formation and early evolution of galaxies in haloes of a different mass. Strong compaction and gas dissipation in field galaxies, followed by a sequence of mergers may have also played a significant role in the field ETG evolution, but not in the evolution of cluster galaxies. Our passive ETG mass-size relation shows a tendency to flatten at $9.6<{\rm log}(M/M_{\odot})<10.5$, where the average size is $\mathrm{log}(R_e/\mathrm{kpc}) = 0.05 \pm 0.22$. This implies that galaxies in the low end of the mass-size relation do not evolve much from $z\sim 2$ to the present, and that their sizes evolve in a similar way in clusters and in the field. BCGs lie on the same mass-size relation as satellites, suggesting that their size evolution is not different at redshift z $\gtrsim$ 2. Half of the active ETGs ($\sim 30\%$ of the ETGs) follow the field passive galaxy mass-size relation, and the other half follow the field active galaxy mass-size relation. These galaxies likely went through a recent merger or neighbor galaxy interaction, and would most probably quench at a later epoch and increase the fraction of passive ETGs in clusters. We do not observe a large population of compact galaxies, as is observed in the field at these redshifts, implying that the galaxies in our clusters are not observed in an epoch close to their compaction.Comment: 15 pages, 10 figures, accepted for publication in Astronomy & Astrophysic