1,182 research outputs found

    Initial thoughts on rapid prototyping techniques

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    This paper sets some context, raises issues, and provides our initial thinking on the characteristics of effective rapid prototyping techniques.After discussing the role rapid prototyping techniques can play in the software lifecycle, the paper looks at possible technical approaches including: heavily parameterized models, reusable software, rapid prototyping languages, prefabrication techniques for system generation, and reconfigurable test harnesses.The paper concludes that a multi-faceted approach to rapid prototyping techniques is needed if we are to address a broad range of applications successfully -- no single technical approach suffices for all potentially desirable applications

    What does leaving the European Union mean? Re-visiting the meaning of the nation state

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    Time for Geography to Catch up with the World

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    This article makes the case that the subject of geography needs to change if we do not want another generation of students to leave school with an outdated view of the world (Rosling et al, 2018). Firstly, we need to ensure that resources and teaching do not present a binary view of developed versus developing countries, as is the case with some exam specifications. I call for the usage of more precise language to describe the bulk of countries that sit between low and high-income countries. Teachers are encouraged to make use of Rosling's four income levels as a graduated conceptual framework to help students understand the range of countries and living conditions experienced. Secondly, development theories need to transcend reductionist and diminished notions of development (such as the Millennium Development Goals) and include a deeper idea of progress - one that encompasses cultural growth, economic and political transformation and affords nations the freedom to chart their own paths

    What to Teach? Conceptualising a Geography Curriculum

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    Starting from the premise that a curriculum must be about knowledge, this article notes the marginalisation of disciplinary knowledge in the Anglo-American school curriculum in recent decades and how contemporary approaches to knowledge (constructivism, instrumentalism and neo-conservatism) are deficient some respect. Instead, the theory of social realism is proposed as a better way to understand the significance of disciplinary knowledge to the education of children and how it can be re-contextualised in the school curriculum. Social realism takes a sociological and epistemological approach to knowledge, moving beyond the positivist/constructivist divide. Geography’s epistemology is examined as comprising systematic geography (propositional knowledge), regional/place-based geography (contextual knowledge) and methods (procedural knowledge), and the relations between each explored. Inducting students into geography depends upon a foundational understanding of all three types of knowledge. Therefore, a robust school curriculum must be constructed with all three knowledge types such that students can enter into its conceptual framework and ways of thinking. Finally, the use of knowledge types in geography curriculum and assessment documents in the UK is discussed

    The role of bacterial protein tyrosine phosphatases in the regulation of the biosynthesis of secreted polysaccharides

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    SIGNIFICANCE: Tyrosine phosphorylation and associated protein tyrosine phosphatases are gaining prominence as critical mechanisms in the regulation of fundamental processes in a wide variety of bacteria. In particular, these phosphatases have been associated with the control of the biosynthesis of capsular polysaccharides and extracellular polysaccharides, critically important virulence factors for bacteria.RECENT ADVANCES: Deletion and over-expression of the phosphatases result in altered polysaccharide biosynthesis in a range of bacteria. The recent structures of associated auto-phosphorylating tyrosine kinases has suggested that the phosphatases may be critical for the cycling of the kinases between monomers and higher order oligomers. CRITICAL ISSUES: Additional substrates of the phosphatases apart from cognate kinases are currently being identified. These are likely to be critical to our understanding of the mechanism by which polysaccharide biosynthesis is regulated. FUTURE DIRECTIONS: Ultimately, these protein tyrosine phosphatases are an attractive target for the development of novel anti-microbials. This is particularly the case for the polymerase and histidinol phosphatase family, which are predominantly found in bacteria. Furthermore, the determination of bacterial tyrosine phosphoproteomes will likely help to uncover the fundamental roles, mechanism and critical importance of these phosphatases in a wide range of bacteria.Alistair James Standish and Renato Moron

    Introduction

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    How the orbital period of a test particle is modified by the Dvali-Gabadadze-Porrati gravity?

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    In addition to the pericentre \omega, the mean anomaly M and, thus, the mean longitude \lambda, also the orbital period Pb and the mean motion nn of a test particle are modified by the Dvali-Gabadadze-Porrati gravity. While the correction to Pb depends on the mass of the central body and on the geometrical features of the orbital motion around it, the correction to nn is independent of them, up to terms of second order in the eccentricity ee. The latter one amounts to about 2\times 10^-3 arcseconds per century. The present-day accuracy in determining the mean motions of the inner planets of the Solar System from radar ranging and differential Very Long Baseline Interferometry is 10^-2-5\times 10^-3 arcseconds per century, but it should be improved in the near future when the data from the spacecraft to Mercury and Venus will be available.Comment: LaTex, 7 pages, 13 references, no tables, no figures. Section 2.3 added. To appear in JCA
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