AN EXPERIMENTAL INVESTIGATION OF HIGH-SPEED AIR-BREATHING VEHICLE PERFORMANCE METRICS

High-speed air-breathing vehicles are one of the main hypersonic vehicles currently being developed. There is a current push by major world powers to develop these vehicles and one of the major limiting factors is engine design. The high-speed air-breathing vehicles necessitate an engine that can perform at higher speeds and higher temperatures, such as a scramjet. This engine is broken into three main parts: the inlet, isolator, and combustor. One of the primary concerns for these vehicles is engine unstart, which is when there is no longer supersonic flow through the engine and the engine can no longer perform. This is typically considered a worst-case scenario for these vehicles and is equated with vehicle loss. This study is broken into two main experiments looking at the inlet and isolator sections of the scramjet flow path. These experiments were done with computational counterparts as the need for complementary studies has been well documented in the literature. Specifically for scramjets, the flight Mach number, Reynolds number, and enthalpy are very difficult to match in ground testing. Thus, there is a distinct need for computational studies to support ground testing in vehicle development. The inlet study uses a crossing shock-wave/boundary-layer interaction as a canonical representation of an inlet, specifically at an off-design-condition with a large shock-wave/boundary layer created in the inlet flow. Then, vortex generators were employed to determine the effect of passive flow control on such an interaction. They were shown to delay separation but cause in increase in flow distortion. The isolator study used a dynamic cylinder model to create a shock train in the wind tunnel test section. This accurately modeled a shock train in an isolator section of a scramjet flow path. Unstart was then created by moving the shock train with the dynamic cylinder which changed the backpressure ratio. Additionally, the asymmetrical nature of the shock train was investigated in the experimental data after the asymmetry was noted in the computations. The experimental data conferred well with the computational data as a strong asymmetrical trend was shown

Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial

Background: Respiratory complications are an important cause of postoperative morbidity. We aimed to investigate whether continuous positive airway pressure (CPAP) administered immediately after major abdominal surgery could prevent postoperative morbidity. Methods: PRISM was an open-label, randomised, phase 3 trial done at 70 hospitals across six countries. Patients aged 50 years or older who were undergoing elective major open abdominal surgery were randomly assigned (1:1) to receive CPAP within 4 h of the end of surgery or usual postoperative care. Patients were randomly assigned using a computer-generated minimisation algorithm with inbuilt concealment. The primary outcome was a composite of pneumonia, endotracheal re-intubation, or death within 30 days after randomisation, assessed in the intention-to-treat population. Safety was assessed in all patients who received CPAP. The trial is registered with the ISRCTN registry, ISRCTN56012545. Findings: Between Feb 8, 2016, and Nov 11, 2019, 4806 patients were randomly assigned (2405 to the CPAP group and 2401 to the usual care group), of whom 4793 were included in the primary analysis (2396 in the CPAP group and 2397 in the usual care group). 195 (8\ub71%) of 2396 patients in the CPAP group and 197 (8\ub72%) of 2397 patients in the usual care group met the composite primary outcome (adjusted odds ratio 1\ub701 [95% CI 0\ub781-1\ub724]; p=0\ub795). 200 (8\ub79%) of 2241 patients in the CPAP group had adverse events. The most common adverse events were claustrophobia (78 [3\ub75%] of 2241 patients), oronasal dryness (43 [1\ub79%]), excessive air leak (36 [1\ub76%]), vomiting (26 [1\ub72%]), and pain (24 [1\ub71%]). There were two serious adverse events: one patient had significant hearing loss and one patient had obstruction of their venous catheter caused by a CPAP hood, which resulted in transient haemodynamic instability. Interpretation: In this large clinical effectiveness trial, CPAP did not reduce the incidence of pneumonia, endotracheal re-intubation, or death after major abdominal surgery. Although CPAP has an important role in the treatment of respiratory failure after surgery, routine use of prophylactic post-operative CPAP is not recommended