10 research outputs found
Medicinal Polypores of the Forests of North America: Screening for Novel Antiviral Activity
Potentiation of Cell-Mediated Host Defense Using Fruitbodies and Mycelia of Medicinal Mushrooms
Biology, Food, Medicinal, and Biotechnological Applications of the Tropical Mushroom Pleurotus tuberregium (Rumph.:Fr.) Singer
Extracts of Polypore Mushroom Mycelia Reduce Viruses in Honey Bees
Waves of highly infectious viruses sweeping through global honey bee populations have contributed to recent declines in honey bee health. Bees have been observed foraging on mushroom mycelium, suggesting that they may be deriving medicinal or nutritional value from fungi. Fungi are known to produce a wide array of chemicals with antimicrobial activity, including compounds active against bacteria, other fungi, or viruses. We tested extracts from the mycelium of multiple polypore fungal species known to have antiviral properties. Extracts from amadou (Fomes) and reishi (Ganoderma) fungi reduced the levels of honey bee deformed wing virus (DWV) and Lake Sinai virus (LSV) in a dose-dependent manner. In field trials, colonies fed Ganoderma resinaceum extract exhibited a 79-fold reduction in DWV and a 45,000-fold reduction in LSV compared to control colonies. These findings indicate honey bees may gain health benefits from fungi and their antimicrobial compounds
Chlorinated Coumarins from the Polypore Mushroom <i>Fomitopsis officinalis</i> and Their Activity against <i>Mycobacterium tuberculosis</i>
An EtOH extract of the polypore mushroom <i>Fomitopsis officinalis</i> afforded two new naturally occurring
chlorinated coumarins, which
were identified as the previously synthesized compounds 6-chloro-4-phenyl-2<i>H</i>-chromen-2-one (<b>1</b>) and ethyl 6-chloro-2-oxo-4-phenyl-2<i>H</i>-chromen-3-carboxylate (<b>2</b>). The structures
of the two isolates were deduced by <i>ab initio</i> spectroscopic
methods and confirmed by chemical synthesis. In addition, an analogue
of each was synthesized as 7-chloro-4-phenyl-2<i>H</i>-chromen-2-one
(<b>3</b>) and ethyl 7-chloro-2-oxo-4-phenyl-2<i>H</i>-chromen-3-carboxylate (<b>4</b>). All four compounds were
characterized physicochemically, and their antimicrobial activity
profiles revealed a narrow spectrum of activity with lowest MICs against
the <i>Mycobacterium tuberculosis</i> complex
The mycelium of the Trametes versicolor (Turkey tail) mushroom and its fermented substrate each show potent and complementary immune activating properties in vitro
Recent progress in research on the pharmacological potential of mushrooms and prospects for their clinical application
International audienceFungi are considered one of the most diverse, ecologically significant, and economically important organisms on Earth. The edible and medicinal mushrooms have long been known by humans and were used by ancient civilizations not only as valuable food but also as medicines. Mushrooms are producers of high- and low-molecular-weight bioactive compounds (alkaloids, lectins, lipids, peptidoglycans, phenolics, polyketides, polysaccharides, proteins, polysaccharide-protein/peptides, ribosomal and non-ribosomal peptides, steroids, terpenoids, etc.) possessing more than 130 different therapeutic effects (analgesic, antibacterial, antifungal, anti-inflammatory, antioxidant, antiplatelet, antiviral, cytotoxic, hepatoprotective, hypocholesterolemic, hypoglycemic, hypotensive, immunomodulatory, immunosuppressive, mitogenic/regenerative, etc.). The early record of Materia Medica shows evidence of using mushrooms for treatment of different diseases. Mushrooms were widely used in the traditional medicine of many countries around the world and became great resources for modern clinical and pharmacological research. However, the medicinal and biotechnological potential of mushrooms has not been fully investigated. This review discusses recent advances in research on the pharmacological potential of mushrooms and perspectives for their clinical application