Additional file 3: Figure S7. of B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis

Dkk-1 is not expressed in epidermis (black arrow), appendices (green arrow) and spindle-like cells (red arrows) in both baseline (A and B) and follow up biopsy (D and E) in a non responder. Streptavidin biotin peroxidase (A and D × 20, B and E x400). RTX treatment had no effect on collagen accumulation (C and F, prior to and following RTX treatment, respectively). Masson’s trichrome × 100 (TIF 876 kb