Scattering matrices and expansion coefficients of Martian analogue palagonite particles

We present measurements of ratios of elements of the scattering matrix of Martian analogue palagonite particles for scattering angles ranging from 3 to 174 degrees and a wavelength of 632.8 nm. To facilitate the use of these measurements in radiative transfer calculations we have devised a method that enables us to obtain, from these measurements, a normalized synthetic scattering matrix covering the complete scattering angle range from 0 to 180 degrees. Our method is based on employing the coefficients of the expansions of scattering matrix elements into generalized spherical functions. The synthetic scattering matrix elements and/or the expansion coefficients obtained in this way, can be used to include multiple scattering by these irregularly shaped particles in (polarized) radiative transfer calculations, such as calculations of sunlight that is scattered in the dusty Martian atmosphere.Comment: 34 pages 7 figures 1 tabl

Real-time PCR reveals a high incidence of Symbiodinium clade D at low levels in four scleractinian corals across the Great Barrier Reef:Implications for symbiont shuffling

Reef corals form associations with an array of genetically and physiologically distinct endosymbionts from the genus Symbiodinium. Some corals harbor different clades of symbionts simultaneously, and over time the relative abundances of these clades may change through a process called symbiont shuffling. It is hypothesized that this process provides a mechanism for corals to respond to environmental threats such as global warming. However, only a minority of coral species have been found to harbor more than one symbiont clade simultaneously and the current view is that the potential for symbiont shuffling is limited. Using a newly developed real-time PCR assay, this paper demonstrates that previous studies have underestimated the presence of background symbionts because of the low sensitivity of the techniques used. The assay used here targets the multi-copy rDNA ITS1 region and is able to detect Symbiodinium clades C and D with > 100-fold higher sensitivity compared to conventional techniques. Technical considerations relating to intragenomic variation, estimating copy number and non-symbiotic contamination are discussed. Eighty-two colonies from four common scleractinian species (Acropora millepora, Acropora tenuis, Stylophora pistillata and Turbinaria reniformis) and 11 locations on the Great Barrier Reef were tested for background Symbiodinium clades. Although these colonies had been previously identified as harboring only a single clade based on SSCP analyses, background clades were detected in 78% of the samples, indicating that the potential for symbiont shuffling may be much larger than currently thought

Connectivity in MEG resting-state networks increases after resective surgery for low-grade glioma and correlates with improved cognitive performance☆

Purpose Low-grade glioma (LGG) patients often have cognitive deficits. Several disease- and treatment related factors affect cognitive processing. Cognitive outcome of resective surgery is unpredictable, both for improvement and deterioration, especially for complex domains such as attention and executive functioning. MEG analysis of resting-state networks (RSNs) is a good candidate for presurgical prediction of cognitive outcome. In this study, we explore the relation between alterations in connectivity of RSNs and changes in cognitive processing after resective surgery, as a stepping stone to ultimately predict postsurgical cognitive outcome. Methods: Ten patients with LGG were included, who had no adjuvant therapy. MEG recording and neuropsychological assessment were obtained before and after resective surgery. MEG data were recorded during a no-task eyes-closed condition, and projected to the anatomical space of the AAL atlas. Alterations in functional connectivity, as characterized by the phase lag index (PLI), within the default mode network (DMN), executive control network (ECN), and left- and right-sided frontoparietal networks (FPN) were compared to cognitive changes. Results: Lower alpha band DMN connectivity was increased after surgery, and this increase was related to improved verbal memory functioning. Similarly, right FPN connectivity was increased after resection in the upper alpha band, which correlated with improved attention, working memory and executive functioning. Discussion Increased alpha band RSN functional connectivity in MEG recordings correlates with improved cognitive outcome after resective surgery. The mechanisms resulting in functional connectivity alterations after resection remain to be elucidated. Importantly, our findings indicate that connectivity of MEG RSNs may be used for presurgical prediction of cognitive outcome in future studies

A gauge invariant and string independent fermion correlator in the Schwinger model

We introduce a gauge invariant and string independent two-point fermion correlator which is analyzed in the context of the Schwinger model (QED_2). We also derive an effective infrared worldline action for this correlator, thus enabling the computation of its infrared behavior. Finally, we briefly discuss possible perspectives for the string independent correlator in the QED_3 effective models for the normal state of HTc superconductors.Comment: 14 pages, LaTe

Towards precision medicine:What are the stratification hypotheses to identify homogeneous inflammatory subgroups

Diverse lines of research testify a link, presumably causal, between immune dysregulation and the development, course and clinical outcome of psychiatric disorders. However, there is a large heterogeneity among the patients? individual immune profile and this heterogeneity prevents the development of precise diagnostic tools and the identification of therapeutic targets. The aim of this review was to delineate possible subgroups of patients on the basis of clinical dimensions, investigating whether they could lead to particular immune signatures and tailored treatments. We discuss six clinical entry points; genetic liability to immune dysregula-tion, childhood maltreatment, metabolic syndrome, cognitive dysfunction, negative symptoms and treatment resistance. We describe the associated immune signature and outline the effects of anti-inflammatory drugs so far. Finally, we discuss advantages of this approach, challenges and future research directions. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/

Disturbed functional brain networks and neurocognitive function in low-grade glioma patients: a graph theoretical analysis of resting-state MEG

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits.

In the developing spinal cord, Onecut transcription factors control the diversification of motor neurons into distinct neuronal subsets by ensuring the maintenance of Isl1 expression during differentiation. However, other genes downstream of the Onecut proteins and involved in motor neuron diversification have remained unidentified. In the present study, we generated conditional mutant embryos carrying specific inactivation of Onecut genes in the developing motor neurons, performed RNA-sequencing to identify factors downstream of Onecut proteins in this neuron population, and employed additional transgenic mouse models to assess the role of one specific Onecut-downstream target, the transcription factor Nkx6.2. Nkx6.2 expression was up-regulated in Onecut-deficient motor neurons, but strongly downregulated in Onecut-deficient V2a interneurons, indicating an opposite regulation of Nkx6.2 by Onecut factors in distinct spinal neuron populations. Nkx6.2-null embryos, neonates and adult mice exhibited alterations of locomotor pattern and spinal locomotor network activity, likely resulting from defective survival of a subset of limb-innervating motor neurons and abnormal migration of V2a interneurons. Taken together, our results indicate that Nkx6.2 regulates the development of spinal neuronal populations and the formation of the spinal locomotor circuits downstream of the Onecut transcription factors

Super Earth Explorer: A Coronagraphic Off-Axis Space Telescope

The Super-Earth Explorer is an Off-Axis Space Telescope (SEE-COAST) designed for high contrast imaging. Its scientific objective is to make the physico-chemical characterization of exoplanets possibly down to 2 Earth radii >. For that purpose it will analyze the spectral and polarimetric properties of the parent starlight reflected by the planets, in the wavelength range 400-1250 nmComment: Accepted in Experimental Astronom

Transference Principles for Log-Sobolev and Spectral-Gap with Applications to Conservative Spin Systems

We obtain new principles for transferring log-Sobolev and Spectral-Gap inequalities from a source metric-measure space to a target one, when the curvature of the target space is bounded from below. As our main application, we obtain explicit estimates for the log-Sobolev and Spectral-Gap constants of various conservative spin system models, consisting of non-interacting and weakly-interacting particles, constrained to conserve the mean-spin. When the self-interaction is a perturbation of a strongly convex potential, this partially recovers and partially extends previous results of Caputo, Chafa\"{\i}, Grunewald, Landim, Lu, Menz, Otto, Panizo, Villani, Westdickenberg and Yau. When the self-interaction is only assumed to be (non-strongly) convex, as in the case of the two-sided exponential measure, we obtain sharp estimates on the system's spectral-gap as a function of the mean-spin, independently of the size of the system.Comment: 57 page