Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase a oncogene.

BACKGROUND: Protein tyrosine phosphatase receptor delta (PTPRD) is a member of a large family of protein tyrosine phosphatases which negatively regulate tyrosine phosphorylation. Neuroblastoma is a major childhood cancer arising from precursor cells of the sympathetic nervous system which is known to acquire deletions and alterations in the expression patterns of PTPRD, indicating a potential tumor suppressor function for this gene. The molecular mechanism, however, by which PTPRD renders a tumor suppressor effect in neuroblastoma is unknown. RESULTS: As a molecular mechanism, we demonstrate that PTPRD interacts with aurora kinase A (AURKA), an oncogenic protein that is over-expressed in multiple forms of cancer, including neuroblastoma. Ectopic up-regulation of PTPRD in neuroblastoma dephosphorylates tyrosine residues in AURKA resulting in a destabilization of this protein culminating in interfering with one of AURKA\u27s primary functions in neuroblastoma, the stabilization of MYCN protein, the gene of which is amplified in approximately 25 to 30% of high risk neuroblastoma. CONCLUSIONS: PTPRD has a tumor suppressor function in neuroblastoma through AURKA dephosphorylation and destabilization and a downstream destabilization of MYCN protein, representing a novel mechanism for the function of PTPRD in neuroblastoma

Ecohydrological implications of aeolian processes in drylands

Aeolian processes, the erosion transport and deposition of soil particles by wind, are dominant geomorphological processes in many drylands, and important feedbacks are known to exist among aeolian, hydrological, and vegetation dynamics (Field et al. 2010; Ravi et al. 2011). The wind, a natural geomorphic agent, has been active as an erosive agent throughout geological times in many parts of the world. Outstanding examples are the extensive loess deposits along the Huanghe River (Yellow River) in China and along the Missouri and Mississippi rivers in the United States. Climatic changes and anthropogenic activities can greatly accelerate soil erosion by wind with implications for soil and vegetation degradation (Kok et al. 2012; Webb and Pierre 2018; Nauman et al. 2018). For instance, in the 1930s, a decreased precipitation coupled with intensive agricultural activities caused a dramatic increase in wind erosion in the Great Plains of the United States, resulting in the so-called Dust Bowl. Wind erosion can be activated also by land-use change. An example is provided by the Mu Us region in North China with an annual precipitation of 400 mm, which was once a grassland partially covered with forest, yet now is one of the major sources of dust in the world as a result of overgrazing and agricultural practices (Wang et al. 2005; Miao et al. 2016)