1 research outputs found
Model of the distribution of diastolic left ventricular posterior wall thickness in healthy adults and its impact on the behavior of a string of virtual cardiomyocytes
Correlation of the thickness of the left ventricular
posterior wall (LVPWd) with various parameters,
including age, gender, weight and height, was investigated
in this study using regression models. Multicenter
derived database comprised over 4,000 healthy individuals.
The developed models were further utilized in the
in vitro-in vivo (IVIV) translation of the drug cardiac
safety data with use of the mathematical model of
human cardiomyocytes operating at the virtual healthy
population level. LVPWd was assumed to be equivalent
to the length of one-dimensional string of virtual cardiomyocyte
cells which was presented, as other physiological factors,
to be a parameter influencing the simulated pseudo-ECG
(pseudoelectrocardiogram), QTcF and QTcF, both native
and modified by exemplar drug (disopyramide) after current
disruption. Simulation results support positive correlation
between the LVPWd and QTcF/QTc. Developed models
allow more detailed description of the virtual population and
thus inter-individual variability influence on the drug cardiac
safet