Equity Returns to Small Bank Investors

Unlike most other small firms, there is an excellent record of the initial equity capitalization details of banking organizations when they are formed, as well as subsequent changes, because of the chartering application and reporting requirements of the banking regulatory authorities. By combining these records with the actual approved acquisition price of small banks, the return received by small bank investors from the time of organization through acquisition is determined. For small banks organized after 1972 and acquired from 1980 and through 1988, yearly mean rates of return ranged from 23.07 percent to 10.49 percent. Generally, these returns exceed S&P 500 returns for similar holding periods, but on a Sharpe Performance Index risk adjusted basis were inferior to S&P portfolios in six of nine holding periods and consistently weaker by the same measure to small company investment on the NYSE for this entire period. This inferior risk adjusted performance was unexpected

Is the treatment of the tear trough deformity with hyaluronic acid injections a safe procedure? A systematic review

Among the various therapeutic options for the treatment of tear trough deformities, the use of hyaluronic acid-based fillers has constantly been increasing. The aim of this research is to conduct a systematic review of the published literature related to the use of hyaluronic acid-based dermal fillers for the treatment of tear trough deformities and possible related complications. A search of the published literature was conducted following the PRISMA guidelines, including PubMed, Cochrane Library, and Ovid databases. Text words and Medical Search Headings (MeSH terms) were used to identify nine articles included in our analysis. The most used filler was Restylane (Galderma). The injection technique was performed through the use of a cannula or, more frequently, with a needle, through the execution of boluses or retrograde release. The injection plane was predominantly the supra-periosteal layer. The most observed side effects were mild and included redness, edema, contour irregularities, bruising, and blue-gray dyschromia. The degree of patient satisfaction was high, with an optimal aesthetic result that was maintained for 6 to 12 months. Although the duration of treatment of tear trough deformities with HA fillers is not comparable to surgical treatment, this is a minimally invasive, safe procedure, quick to perform, and with a high degree of patient satisfaction

A Chemical Genetic Screen for Modulators of Asymmetrical 2,2′-Dimeric Naphthoquinones Cytotoxicity in Yeast

BACKGROUND: Dimeric naphthoquinones (BiQ) were originally synthesized as a new class of HIV integrase inhibitors but have shown integrase-independent cytotoxicity in acute lymphoblastic leukemia cell lines suggesting their use as potential anti-neoplastic agents. The mechanism of this cytotoxicity is unknown. In order to gain insight into the mode of action of binaphthoquinones we performed a systematic high-throughput screen in a yeast isogenic deletion mutant array for enhanced or suppressed growth in the presence of binaphthoquinones. METHODOLOGY/PRINCIPAL FINDINGS: Exposure of wild type yeast strains to various BiQs demonstrated inhibition of yeast growth with IC(50)s in the microM range. Drug sensitivity and resistance screens were performed by exposing arrays of a haploid yeast deletion mutant library to BiQs at concentrations near their IC(50). Sensitivity screens identified yeast with deletions affecting mitochondrial function and cellular respiration as having increased sensitivity to BiQs. Corresponding to this, wild type yeast grown in the absence of a fermentable carbon source were particularly sensitive to BiQs, and treatment with BiQs was shown to disrupt the mitochondrial membrane potential and lead to the generation of reactive oxygen species (ROS). Furthermore, baseline ROS production in BiQ sensitive mutant strains was increased compared to wild type and could be further augmented by the presence of BiQ. Screens for resistance to BiQ action identified the mitochondrial external NAD(P)H dehydrogenase, NDE1, as critical to BiQ toxicity and over-expression of this gene resulted in increased ROS production and increased sensitivity of wild type yeast to BiQ. CONCLUSIONS/SIGNIFICANCE: In yeast, binaphthoquinone cytotoxicity is likely mediated through NAD(P)H:quonine oxidoreductases leading to ROS production and dysfunctional mitochondria. Further studies are required to validate this mechanism in mammalian cells

Energy Technology Progress for Sustainable Development

Energy security is a fundamental part of a country`s national security. Access to affordable, environmentally sustainable energy is a stabilizing force and is in the world community`s best interest. The current global energy situation however is not sustainable and has many complicating factors. The primary goal for government energy policy should be to provide stability and predictability to the market. This paper differentiates between short-term and long-term issues and argues that although the options for addressing the short-term issues are limited, there is an opportunity to alter the course of long-term energy stability and predictability through research and technology development. While reliance on foreign oil in the short term can be consistent with short-term energy security goals, there are sufficient long-term issues associated with fossil fuel use, in particular, as to require a long-term role for the federal government in funding research. The longer term issues fall into three categories. First, oil resources are finite and there is increasing world dependence on a limited number of suppliers. Second, the world demographics are changing dramatically and the emerging industrialized nations will have greater supply needs. Third, increasing attention to the environmental impacts of energy production and use will limit supply options. In addition to this global view, some of the changes occurring in the US domestic energy picture have implications that will encourage energy efficiency and new technology development. The paper concludes that technological innovation has provided a great benefit in the past and can continue to do so in the future if it is both channels toward a sustainable energy future and if it is committed to, and invested in, as a deliberate long-term policy option

Preconditioning-induced ischemic tolerance: a window into endogenous gearing for cerebroprotection

Ischemic tolerance defines transient resistance to lethal ischemia gained by a prior sublethal noxious stimulus (i.e., preconditioning). This adaptive response is thought to be an evolutionarily conserved defense mechanism, observed in a wide variety of species. Preconditioning confers ischemic tolerance if not in all, in most organ systems, including the heart, kidney, liver, and small intestine. Since the first landmark experimental demonstration of ischemic tolerance in the gerbil brain in early 1990's, basic scientific knowledge on the mechanisms of cerebral ischemic tolerance increased substantially. Various noxious stimuli can precondition the brain, presumably through a common mechanism, genomic reprogramming. Ischemic tolerance occurs in two temporally distinct windows. Early tolerance can be achieved within minutes, but wanes also rapidly, within hours. Delayed tolerance develops in hours and lasts for days. The main mechanism involved in early tolerance is adaptation of membrane receptors, whereas gene activation with subsequent de novo protein synthesis dominates delayed tolerance. Ischemic preconditioning is associated with robust cerebroprotection in animals. In humans, transient ischemic attacks may be the clinical correlate of preconditioning leading to ischemic tolerance. Mimicking the mechanisms of this unique endogenous protection process is therefore a potential strategy for stroke prevention. Perhaps new remedies for stroke are very close, right in our cells

Multi-view Three-Dimensional Interferometric Inverse Synthetic Aperture Radar

Three-dimensional (3D) ISAR imaging has been proven feasible by combining traditional ISAR imaging and interferometry. Such technique, namely Inteferometric ISAR (InISAR), allows for the main target scattering centres to be mapped into a 3D spatial domain, therefore forming 3D images under the form of 3D point clouds. 3D InISAR overcomes some main limitations of traditional 2D ISAR imaging, such as the problem of cross-range scaling and unknown image projection plane (IPP). Despite the great advantage of 3D imaging over traditional 2D imaging, some issues remain, such as scatterer scintillation, shadowing effects, poor SNR, etc., which limit the effectiveness of 3D imaging. A solution to these issues can be found in the use of multiple 3D views, which can be obtained exploiting either multi-temporal or multi-perspective configurations or a combination of both. This paper propose this concept and develops the image fusion algorithms that are necessary to produce multi-view 3D ISAR images. The effectiveness of the proposed technique is tested by using real data collected with a multi-static InISAR system