Chorzy trudni nietypowiCałkowity blok przedsionkowo-komorowy w przebiegu ziarniniakowatości Wegenera: opis przypadku i przegląd piśmiennictwa

Involvement of the conduction system of the heart in Wegener’s granulomatosis (WG) is rare. We present a 53-year-old man with WG pulmonary, renal and left eyeball involvement and with a high initial level of cANCA (1: 640). He was treated with steroids, cyclophosphamide and cyclosporine. After 14 months he presented with lethargy and presyncope due to a complete atrio-ventricular block with an escape rhythm of 35 beats/min. The temporary pacing electrode was inserted, followed by permanent DDDR pacemaker implantation on the third day as the block persisted despite WG treatment intensification. Clinical picture showed the disease in a progressive state

Preliminary studies of antimicrobial activity of new synthesized hybrids of 2-thiohydantoin and 2-quinolone derivatives activated with blue light

Thiohydantoin and quinolone derivatives have attracted researchers’ attention because of a broad spectrum of their medical applications. The aim of our research was to synthesize and analyze the antimicrobial properties of novel 2-thiohydantoin and 2-quinolone derivatives. For this purpose, two series of hybrid compounds were synthesized. Both series consisted of 2-thiohydantoin core and 2-quinolone derivative ring, however one of them was enriched with an acetic acid group at N3 atom in 2-thiohydantoin core. Antibacterial properties of these compounds were examined against bacteria: Staphylococcus aureus, Bacillus subtilis, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae. The antimicrobial assay was carried out using a serial dilution method to obtain the MIC. The influence of blue light irradiation on the tested compounds was investigated. The relative yield of singlet oxygen ((1)O(2)*, (1)Δ(g)) generation upon excitation with 420 nm was determined by a comparative method, employing perinaphthenone (PN) as a standard. Antimicrobial properties were also investigated after blue light irradiation of the suspensions of the hybrids and bacteria placed in microtitrate plates. Preliminary results confirmed that some of the hybrid compounds showed bacteriostatic activity to the reference Gram-positive bacterial strains and a few of them were bacteriostatic towards Gram-negative bacteria, as well. Blue light activation enhanced bacteriostatic effect of the tested compounds

Geomechanical assessments of longwall working stability – a case study

The stability of longwall mining is one of the most important and the most difficult aspects of underground coal mining. The loss of longwall stability can threaten lives, disrupt the continuity of the mining operations, and it requires significant materials and labour costs associated with replacing the damages. In fact, longwall mining stability is affected by many factors combined. Each case of longwall mining has its own unique and complex geological and mining conditions. Therefore, any case study of longwall stability requires an individual analysis. In Poland, longwall mining has been applied in underground coal mining for years. The stability of the longwall working is often examined using an empirical method. A regular longwall mining panel (F3) operation was designed and conducted at the Borynia-Zofiówka-Jastrzębie (BZJ) coal mine. During its advancement, roof failures were observed, causing a stoppage. This paper aims to identify and determine the mechanisms of these failures that occurred in the F3 longwall. A numerical model was performed using the finite difference method - code FLAC2D, representing the exact geological and mining conditions of the F3 longwall working. Major factors that influenced the stability of the F3 longwall were taken into account. Based on the obtained results from numerical analysis and the in-situ observations, the stability of the F3 longwall was discussed and evaluated. Consequently, recommended practical actions regarding roof control were put forward for continued operation in the F3 longwall panel