Expert opinion on the creating and operating of the regional Pulmonary Embolism Response Teams (PERT). Polish PERT Initiative

Pulmonary Embolism Response Team (PERT) is a multidisciplinary team established to stratify riskand choose optimal treatment in patients with acute pulmonary embolism (PE). Established for thefirst time at Massachusetts General Hospital in 2013, PERT is based on a concept combining a RapidResponse Team and a Heart Team. The growing role of PERTs in making individual therapeutic decisionsis identified, especially in hemodynamically unstable patients with contraindications to thrombolysis orwith co-morbidities, as well as in patients with intermediate-high risk in whom a therapeutic decisionmay be difficult. The purpose of this document is to define the standards of PERT under Polish conditions,based on the experience of teams already operating in Poland, which formed an agreement calledthe Polish PERT Initiative. The goals of Polish PERT Initiative are: improving the treatment of patientswith PE at local, regional and national levels, gathering, assessing and sharing data on the effectivenessof PE treatment (including various types of catheter-directed therapy), education on optimal treatmentof PE, creating expert documents and supporting scientific research, as well as cooperation with othercommunities and scientific societies

Ammonia-modified Co(II) sites in zeolites : IR spectroscopy and spin resolved charge transfer analysis for NO adsorption complexes

IR spectroscopic studies and quantum chemical modeling (aided by the analysis of charge transfer processes between co-adsorbed ammonia and the Co(II)–NO adduct) evidence that donor ammonia molecules, ligated to extraframework Co2+ centers in zeolites, vitally affect the strength of the N–O bond. Calculations indicate that versatility of ammine nitrosyl complexes, differing in the number of NH3 ligands as well as in the geometry and electronic structure of the Co–N–O unit (showing variable activation of NO) may co-exist in zeolite frameworks. However, only combined analysis of experimental and calculation results points to the adducts with three or five NH3 coligands as decisive. The novel finding concerning the interpretation of discussed IR spectra is the assignment of the most down-shifted bands at 1600–1615 cm−1 to the N–O stretch in the singlet [Co(NH3)3(NO)]2+ adduct, in place of tentative ascription to pentaammine adducts. Theory indicates also that the Co(II) center (with manifold of close-lying electronic and spin states) acts as a tunable electron donor where the spin state may open or close specific channels transferring electron density from the donor ligands (treated as the part of environment) to the NO molecule

Electronic propensity of Cu(II) versus Cu(I) sites in zeolites to activate NO – Spin- and orbital-resolved Cu–NO electron transfer

Electronic factors responsible for the notable decline of NO activation by Cu(II) with respect to Cu(I) sites in zeolites are investigated within spin-resolved analysis of electron transfer channels between the copper center and the substrate. The results of natural orbitals for chemical valence (NOCV) charge transfer analysis for a minimal model of Cu(II) sites in zeolite ZSM-5 ({T1Cu}+ NO) are compared with those for Cu(I)–NO and referenced to an interaction of NO with bare Cu+ cations. The bonding of NO, which is an open-shell and non-innocent ligand, gives rise to a noticeable nondynamical correlation in the adduct with Cu(II) (reflected in a broken-symmetry solution obtained at the density functional theory (DFT) level). Four distinct components of electron transfer between the copper and NO are identified: (i) donation of an unpaired electron from the NO π∥* antibonding orbital to the Cu species, (ii) backdonation from copper d⊥ to the NO antibonding orbital, (iii) “covalent” donation from NO π∥ and Cu d∥ orbitals to the bonding region, and (iv) donation from the nitrogen lone pair to Cus,d. Large variations in channel identity and significance may be noted among studied systems and between spin manifolds: channel i is effective only in the bonding of NO with either a naked Cu+ cation or Cu(II) site. Channel ii comes into prominence only for the model of the Cu(I) site: it strongly activates the NO bond by populating antibonding π*, which weakens the N–O bond, in contrast to channel i depopulating the antibonding orbital and strengthening the N–O bond. Channels iii and iv, however, may contribute to the strength of the bonding between NO and copper, and are of minor importance for the activation of the NO bond. This picture perfectly matches the IR experiment: interaction with either Cu(II) sites or a naked Cu+ cation imposes a comparable blue-shift of NO stretching frequency, while the frequency becomes strongly red-shifted for a Cu(I) site in ZSM-5 due to enhanced π* backdonation

NV nanodiamond doped fiber for magnetic field mapping

The advances in fluorescent diamond-based magnetic field sensors have led this technology into the field of fiber optics. Recently, devices employing diamond nanobeams or diamond chips embedded on an optical fiber tip enabled achieving fT-level sensitivities. Nevertheless, these demonstrations were still confined to operation over localized magnetic field sources. A new approach of volumetric incorporation of nanodiamonds into the optical fiber core enables optical fibers sensitive to magnetic field at any point along the fiber length. We show that information on the perturbed spin state of a diamond nitrogen-vacancy color center can be transmitted over a macroscopic length in an optical fiber, in presence of noise from large concentration of the color centers along the fiber. This is exploited in optical readout at the fiber output not only of the magnetic field value, but also spatially variable information on the field, which enables the localization of its source