9 research outputs found
Bone mineral density and bone remodeling markers in chronic low back pain patients with active discopathy: A case-control exploratory study.
OBJECTIVE:We aimed to compare bone mineral density (BMD) and bone remodeling markers in chronic low back pain (cLBP) patients with and without active discopathy (Modic 1 changes). DESIGN:We conducted a single center case-control exploratory study. For 18 months, all patients referred to a tertiary care physical medicine and rehabilitation department in France were consecutively screened. Patients fulfilling the inclusion criteria were prospectively enrolled. Cases were defined as cLBP patients with lumbar active discopathy detected on MRI and controls as cLBP patients without active discopathy. Bone mineral density (BMD) at the spine, femoral neck and total femur was assessed by dual-energy X-ray absorptiometry, and bone remodeling markers were assessed in fasting serum samples. Overall, 37 cLBP patients (13 cases and 24 controls) fulfilled inclusion criteria and were included. RESULTS:The median age was 42.0 years (Q1-Q3: 36.0-51.0) and mean (SD) LBP duration 72.3 (57.4) months. We found that BMD and levels of bone remodeling markers in cLBP patients did not differ with and without active discopathy. CONCLUSION:Our results do not support the association between active discopathy and systemic bone fragility
Flow chart of patients with chronic low back pain (cLBP) screened from December 2014 to May 2016 and reasons for non-inclusion.
<p>BMI: body mass index.</p
Time elapsed between MRI and BMD assessment, at inclusion.
<p>Time elapsed between MRI and BMD assessment, at inclusion.</p
Patients’ demographics and cLBP characteristics at inclusion.
<p>Patients’ demographics and cLBP characteristics at inclusion.</p
Patients’ physical examination findings at inclusion.
<p>Patients’ physical examination findings at inclusion.</p
Comparisons of demographical risk factors for osteoporosis, prevalent vertebral fractures and bone mineral density between Modic 0 and Modic 1 cLBP patients between Modic 0 and Modic 1 cLBP patients.
<p>Comparisons of demographical risk factors for osteoporosis, prevalent vertebral fractures and bone mineral density between Modic 0 and Modic 1 cLBP patients between Modic 0 and Modic 1 cLBP patients.</p
Comparisons of bone remodeling markers between Modic 0 and Modic 1 cLBP patients.
<p>Comparisons of bone remodeling markers between Modic 0 and Modic 1 cLBP patients.</p
Patients’ biological findings at inclusion.
<p>Patients’ biological findings at inclusion.</p