Efficacy of Educomp Smart Class

Explosion of knowledge is opening new branches of knowledge. Nowadays we have entered into wisdom society from knowledge society. ICT has changed the all aspects of human being. Way of living is being changed and thus role of society as well as school is also is shifting from conventional class room to ICT oriented smart classroom further more to virtual classroom. Innovative apparatus, devices are mushrooming, hence being a teacher we cannot live isolated. If we do not make ourselves ICT- friendly we cannot perform our duty accordingly. Smart class is today’s demand; it does not completely do away with the traditional method of teaching. Rather it seeks to club the use of technology with conventional methods of teaching. The consequential merchandise is a harmonious blend of the modern and the traditional. For instance, the teacher while teaching a lesson on tsunami will supplement the information given in books by showing a video of how a tsunami erupts. All of us know that if we teach by doing or playing and with audio visual aid, learning occurs perfectively. DOI: 10.17762/ijritcc2321-8169.16043

Application of Motivational Enhancement Therapy in Group settings among Patients with Substance Abuse

Background: Substance abuse is defined as the use of a drug or any other substance for a non-medical purpose with the aim of producing some type of "mind-altering "effect in the users. Motivational Enhancement Therapy (MET) is a systematic intervention approach for evoking change. It is based on principles of motivational psychology and is designed to produce rapid and internal motivation. Aims: The present study aims to assess and compare desire to quit substance use among substance users and the effectiveness of Motivation Enhancement Therapy on the desire to quit substance use in an experimental group. Sample and Sampling: A total number of 70 participants were selected using purposive sampling technique. The sample comprised of 35 from inpatient unit and 35 from the out-patient department of psychiatry, Kalpana Chawla Government Medical College and Hospital, Karnal, Haryana, India. Results and Conclusions: The present study suggests that comprehensive patient-friendly treatments are more effective in increasing the desire to quit substance use than the standard pharmacological treatment.  Hence, combining pharmacolo­gical treatment with appropriate psychosocial interventions focusing on the specific problem of the patient may provide a better outcome than either one alone. Clinicians can arrange the clinical teaching regarding MET for a larger group at whole including family interventions. Keywords: Motivation enhancement therapy, substance abus

Diagnosis and Recommendation Integrated System (DRIS) approach on Nutritional Diagnosis in Fruit crops- A Review

Diagnosis and Recommendation Integrated System (DRIS) is widely used statistical approach for interpretation of the plant tissue analysis data and to diagnose the plant nutreint needs much earlier than the reduction of crop yield with greater accuracy. It helps in simultaneous identifying imbalances, deficiencies and excesses of crop nutrients and ranks them in the order of their importance for their remedial steps. The DRIS norms based on foliar composition can developed in any crop and at any stage of its development. It provides a mathematical means of ordering large number of nutrient ratios into nutrient indices that can be easily interpreted. The nutrient ranges been established as deficient, low, optimum, high and excessive based on the mean of nutrient concentration and standard deviation from high yielding population to serve as a guide for a quick and routine diagnostic and advisory purpose. The major advantage of DRIS lies in its ability to minimize the effect of variation in tissue age on diagnosis, which allows a choice of wider range of tissues than permissible under the conventional critical value approach. Thus, DRIS is holistic in nature for identification of nutrient imbalance in crops and formulation of nutrient management strategies for achieving higher yields

ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC ACTIVITY IN ETHYL ACETATE FRACTION OF THE FRUITS OF XYLOCARPUS GRANATUM AND XYLOCARPUS MOLUCCENSIS

Objectives: Although various species of Xylocarpus i. e. Granatum, moluccensis are known for their medicinal properties. Yet, its anti-diabetic activity remains to be defined. So the aim of this study was to evaluate the antihyperglycemic and antidyslipidemic activity in ethyl acetate fraction of the fruits of X. granatum and X. moluccensis on validated animal models as well as in-vitro glucose uptake stimulatory effect and their cytotoxicity effect in L6 skeletal muscle cells.Methods: The ethyl acetate fraction of the fruits of X. granatum and X. moluccensis were administered to diabetic groups daily up to 10 days for prolonged study. Biochemical parameters notably glucose tolerance, insulin level, lipid profile were assessed. The ethyl acetate fraction of the fruits of X. granatum and X. moluccensis were also tested for glucose uptake effect by skeletal muscle cells in the concentration dependent manner.Results: The present study show that the ethyl acetate fraction of the fruits of X. granatum as well as X. moluccensis are effective in improving glucose tolerance, declining blood glucose as well as serum cholesterol and triglycerides levels in low dosed streptozotocin-induced diabetic rats and dyslipidemic hamsters, respectively. These fractions were also found efficient in increasing glucose uptake by L6 skeletal muscle cells but did not show any effect on cell viability of L6 skeletal muscle cells.Conclusion: Based on the results, the present study revealed that ethyl acetate fraction of the fruits of X. granatum and X. moluccensis lowered blood glucose profile by increasing the glucose uptake by L-6 and this may be the possible mechanisms for the antidiabetic and antidyslipidemic action

ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC POTENTIAL OF IPOMOEA BATATAS LEAVES IN VALIDATED DIABETIC ANIMAL MODELS

Objective: The present study was undertaken to investigate the antidiabetic potential of the leaves of Ipomoea batatas.Methods: The crude powder, 95% ethanolic, 50% ethanolic and aqueous extracts of Ipomoea batatas leaves were administered to normoglycemic and streptozotocin (STZ)-induced diabetic rats in a single dose study. The chloroform, butanol and aqueous fractions of aqueous extract were investigated for their antihyperglycemic on STZ-induced diabetic rats. Multiple dose study of an aqueous fraction was also done in STZ and neonatal STZ-induced diabetic rats. Further, the aqueous fraction was measured against the alpha glucosidase and aldose reductase enzymes, and glucose uptake in L6 myotubes.Results: The aqueous extract showed significant lowering of postprandial hyperglycemia of post sucrose loaded normal rats and significantly declined the blood glucose level of STZ-induced diabetic rats. The aqueous fraction at a single dose of 100 mg/kg b. w in comparison with chloroform and butanol fractions significantly lowered the blood glucose level of STZ-induced diabetic rats. The aqueous fraction in a multiple dose study were found to significantly improved the percent glycated hemoglobin (%HbA1c), fasting blood glucose, oral glucose tolerance (OGTT), serum insulin, lipid profile, liver and kidney parameters in STZ-induced diabetic rats. Marked improvement in OGTT and serum insulin levels was also found in neonatal STZ-induced diabetic rats. In vitro study, the aqueous fraction of I. batatas increased glucose uptake in L6 myotubes and inhibits the α-glucosidase and aldose reductase enzymes.Conclusion: The present study demonstrated the significant antidiabetic activity of the I. batatas leaves by promoting insulin secretion, alpha glucosidase and aldose reductase enzyme inhibition.Â

Effective carbon partitioning driven by exotic phloem-specific regulatory elements fused to the Arabidopsis thaliana AtSUC2 sucrose-proton symporter gene

<p>Abstract</p> <p>Background</p> <p><it>AtSUC2 </it>(At1g22710) from <it>Arabidopsis thaliana </it>encodes a phloem-localized sucrose/proton symporter required for efficient photoassimilate transport from source tissues to sink tissues. <it>AtSUC2 </it>plays a key role in coordinating the demands of sink tissues with the output capacity of source leaves, and in maintaining phloem hydrostatic pressure during changes in plant-water balance. Expression and activity are regulated, both positively and negatively, by developmental (sink to source transition) and environmental cues, including light, diurnal changes, photoassimilate levels, turgor pressure, drought and osmotic stress, and hormones.</p> <p>Results</p> <p>To assess the importance of this regulation to whole-plant growth and carbon partitioning, <it>AtSUC2 </it>cDNA was expressed from two exotic, phloem-specific promoters in a mutant background debilitated for AtSUC2 function. The first was a promoter element from Commelina Yellow Mottle Virus (CoYMV), and the second was the <it>rolC </it>promoter from <it>Agrobacterium rhizogenes</it>. <it>CoYMVp::AtSUC2 </it>cDNA restored growth and carbon partitioning to near wild-type levels, whereas plants harboring <it>rolCp::AtSUC2 </it>cDNA showed only partial complementation.</p> <p>Conclusion</p> <p>Expressing <it>AtSUC2 </it>cDNA from exotic, phloem-specific promoters argues that strong, phloem-localized expression is sufficient for efficient transport. Expressing <it>AtSUC2 </it>from promoters that foster efficient phloem transport but are subject to regulatory cascades different from the endogenous sucrose/proton symporter genes has implications for biotechnology.</p

Analysis of gut bacteriome of in utero arsenic-exposed mice using 16S rRNA-based metagenomic approach

IntroductionApproximately 200 million people worldwide are affected by arsenic toxicity emanating from the consumption of drinking water containing inorganic arsenic above the prescribed maximum contaminant level. The current investigation deals with the role of prenatal arsenic exposure in modulating the gut microbial community and functional pathways of the host.Method16S rRNA-based next-generation sequencing was carried out to understand the effects of in utero 0.04 mg/kg (LD) and 0.4 mg/kg (HD) of arsenic exposure. This was carried out from gestational day 15 (GD-15) until the birth of pups to understand the alterations in bacterial diversity.ResultsThe study focused on gestational exposure to arsenic and the altered gut microbial community at phyla and genus levels, along with diversity indices. A significant decrease in firmicutes was observed in the gut microbiome of mice treated with arsenic. Functional analysis revealed that a shift in genes involved in crucial pathways such as insulin signaling and non-alcoholic fatty liver disease pathways may lead to metabolic diseases in the host.DiscussionThe present investigation may hypothesize that in utero arsenic exposure can perturb the gut bacterial composition significantly as well as the functional pathways of the gestationally treated pups. This research paves the way to further investigate the probable mechanistic insights in the field of maternal exposure environments, which may play a key role in epigenetic modulations in developing various disease endpoints in the progeny