Rehabilitation after Amputation: Psychotherapeutic Intervention Module in Indian Scenario

Psychological aspects of adjustment to amputation are varied and not addressed in the present treatment regime. There is no research evidence available of psychological intervention and outcome in Indian scenario. One hundred and seventy-three consecutive patients with limb amputations were randomly assigned to psychotherapeutic intervention module (PIM, study group) (n=90) and treatment as usual group (TAU, control group) (n=83). Patients with psychotic disorder were excluded from the study. Carroll Rating Scale for Depression (CRSD), State-Trait Anxiety Inventory (STAI), Amputees Body Image Scale (ABIS), and Impact of Event Scale (IES) along with specially designed information schedule were administered individually. Structured psychotherapeutic module was developed for the intervention. Patients in PIM group were given six therapy sessions, addressing the specific areas of concern. All patients were evaluated on the same tools after two months of therapy. Analysis showed that after treatment a significant reduction in scores was noted on CRSD, STAI, ABIS, and IES in the PIM group. On the TAU group a significant reduction was seen only in the ABIS. The psychological intervention module proposed by authors was efficacious in alleviating the psychological distress, depression, and anxiety and thus was vastly superior to the conventional method of management of amputees

Study of demographic profile and causative factor in female infertility

Background: Infertility is a global health concern affecting millions of couples worldwide, with a significant impact on physical health and societal disparities. This study investigates female infertility in a specific population in India. Methods: The study, conducted at Nehru Hospital, BRD Medical College, Gorakhpur during September 2019 to August 2020 involved 150 infertile couples seeking conception assistance. Demographic profiles, causative factors, and management approaches were explored. Data were collected through medical histories, physical examinations, and various investigations. Results: Of the infertile women, 57.33% experienced primary infertility, and 42.66% had secondary infertility, with the 26-30 age group being the most affected. A majority resided in rural areas (64.67%), followed Hinduism (87.33%), and 65.33% had at least a matriculation level of education. Most women were housewives (90%). Male partners exhibited addictive habits in 37.33% of cases. The study revealed the complexity of female infertility, with factors such as pelvic inflammatory disease, polycystic ovarian syndrome, myoma of the uterus, uterine anomalies, endometriosis, and tubal pathology playing crucial roles. Conclusions: This study provides valuable insights into the multifaceted nature of female infertility. It highlights the importance of tailored diagnosis and treatment approaches to address specific causes. The findings challenge assumptions about the correlation between demographic factors, such as religion, education, and occupation, and infertility outcomes. Male factors, particularly addictive habits, are also significant contributors to infertility. Further research is needed to gain a broader understanding of infertility factors in diverse populations

Relation of Depression, Anxiety, and Quality of Life with Outcome after Percutaneous Transluminal Coronary Angioplasty

Background. Despite, increasing number of percutaneous transluminal coronary angioplasty (PTCA) being performed, there is a paucity of Indian studies on the psychological effects of PTCA. Aim. To study the relation of anxiety, depression, and health related quality of life with outcome after PTCA. Methods. A total of 35 patients undergoing PTCA were included in the present project with their informed consent. All patients filled a specially designed proforma, the Hospital Anxiety and Depression Scale, Coronary Scale, Seattle Angina Questionnaire, and a health related quality of life measure (EQ 5D) one day before undergoing PTCA. Three days after PTCA patients were reassessed with the Hospital anxiety & depression scale, Seattle angina questionnaire and the EQ 5D. Results. Analysis showed that 46% had significant anxiety and 32.1% had significant depression before PTCA. Following successful PTCA, none of the patients had significant anxiety, and only 2 (3.6%) had significant depression. On the Seattle Angina Questionnaire, physical limitation reduced from 67.9 to 48. Disease perception improved from 21.2 to 37.1. On the EQ5D, the health status improved from 42.7 before PTCA to 78.7 after PTCA. Conclusion. Successful PTCA resulted in significant reduction in anxiety, depression, and physical limitation and improvement in disease perception and health status

STEVENS-JOHNSON SYNDROME DUE TO ADVERSE DRUG REACTIONS: A CASE SERIES

Stevens-Johnson syndrome (SJS) is a rare, serious disorder affecting skin and mucous membranes. It is one of the few serious dermatological adverse effects of drugs encountered in clinical practice which is characterized by blisters and rash on skin, mucous membranes, swelling over face and lips, and hyperpigmentation. After that, the outer layer of affected skin becomes dead, sheds, and starts to heal after several days of inflicting injury. Here, we present a case series of ofloxacin and chloroquine induced SJS after the consent given by patients. First case is a 62 years old male received Ofloxacin and second patient is a 40 years old male received chloroquine. Both patients experienced a severe skin reaction which was diagnosed as SJS. The above-mentioned medications will be implicated in cases of SJS. We should prescribe these medications with extreme caution

Psychiatric comorbidity in multiple sclerosis

Aim: To study the prevalence of psychiatric comorbidities in patients of multiple sclerosisand their association to the degree of disability. Method: Psychiatric symptoms were assessed in 90 patients of multiple sclerosis using GHQ-12, MMSE, HADS, Beck Depression Inventory and AUDIT. Neurological disability wasassessed using Expanded Disability Status Scale. Correlations were determined between EDSS scores and psychiatric scale scores. Result: 61% of patients had significant psychological distress. Depression was most common (38.8%) which was followed by anxiety symptoms (27.8%). Cognitive functioning was relatively intact in patients with mild to moderate neurological disability. Alcohol abusewas mostly restricted to male gender. Conclusion: Psychiatric illness is highly prevalent in patients of multiple sclerosis leading to poor quality of life and significant distress. Psychiatric disability was higher in patients who had greater deterioration in neurological function. All cases of MS should be assessed for psychiatric morbidities as can be alleviated by appropriate intervention

Restricted rotation about Nsp2-Csp3 bond through π-electronic interactions: A 1H NMR study

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Planktonic Scenario of the River Ganga & Yamuna at Prayagraj in COVID-19 Lockdown: A Case Study

Ganga is the most prestigious river of India. The COVID-19 lockdown may have forced us to stay indoors, but it has been boon for pollution-ridden Ganga and Yamuna. Plankton is tiny organisms drifting with water current, influenced by river physical and chemical factors. During lockdown anthropogenic factors were reduced which affected water and plankton quality. Plankton samples were collected from the upstream of the river Ganga (Shankerghat, latitude 25030’28” N and longitude, 81052’10”E) and Yamuna (near boat club, latitude 25024’29”N and longitude 81054’50”E) at Prayagraj, during national lockdown. In the before lockdown period (2019), total 28 planktonic taxa were recorded from the river Ganga, among them 10 taxa from Bacillariophyceae, 15 from Chlorophyceae and 3 from Myxophyceae. While during LD period total 54 genera with 86 species was recorded (Bacillariophyceae 10 taxa, Chlorophyceae 23 taxa, Myxophyceae 9 taxa, Euglenophyceae 2 taxa, Dianophyceae, 1, Rotiferea 7 taxa, Protozoa 2 taxa). Various species of green algae were observed in this small period of lockdown, some species were not observed since a long, like Pediastrum tetras, Scenedesmus abundans, Ankistrodesmus fusiformis, and Brachionus angularis. Various species of phytoplankton and zooplankton were in reproductive phase because river was flowing silently, without any internal and external disturbance. Ganga was more affected by anthropogenic activity and factory discharge than Yamuna So lack of chemicals in the water and minimum human interference favoured auto rejuvenation of Ganga in terms of plankton quality, diversity and reproduction behaviour. Such type of environmental changes may stimulate for origin of new species and disappear or reappear of various aquatic species