BSRS: Best Stable Route Selection Algorithm for Wireless Sensor Network Applications

Topological changes in sensor networks frequently render routing paths unusable. Such recurrent path failures have detrimental effects on the network ability to support QoS-driven services. Because of connectivity richness in sensor networks, there often exist multiple paths between a source and a destination. Since many applications require uninterrupted connectivity of a session, the ability to find long-living paths can be very useful. In this paper, we propose Best Stable Route Selection (BSRS) approach based on Artificial Bee Colony based search algorithm, ensures that contributes stable quality performance of network and to calculate the best stable path services randomly based on QoS parameter requirements and existing circulation load; so that efficient route selection can easily capture by designing of proposed BSRS approach. The implementation of the proposed BSRS technique is implemented using NS2 simulation environment and the AODV routing protocol is used to incorporate the proposed algorithm. The experimental results are measured in terms of end to end delay, throughput, packet delivery ratio, and energy consumption and routing overhead. The results show the proposed BSRS algorithm improves the flexibility of network node and performance of network when multiple inefficient paths exist

Pulmonary Hypertension in Heart Failure Patients

The development of pulmonary hypertension (PH) in patients with heart failure is associated with increased morbidity and mortality. In this article, the authors examine recent changes to the definition of PH in the setting of left heart disease (PH-LHD), and discuss its epidemiology, pathophysiology and prognosis. They also explore the complexities of diagnosing PH-LHD and the current evidence for the use of medical therapies, promising clinical trials and the role of left ventricular assist device and transplantation

PROCESS VALIDATION OF VALACYCLOVIR TABLETS BY OPTIMISING PROCESS PARAMETERS

ABSTRACT In the present study, Valacyclovir tablets were formulated using different formulation parameters and their effects on the dissolution rate of these tablets were evaluated. The binding agent used in this study was Povidone. Tablets were prepared by wet granulation method and were evaluated for various parameters like weight variation, hardness, friability, disintegration time, drug content and in vitro dissolution studies. This Process validation report for Valacyclovir Hydrochloride Tablets 500mg & 1gram common blend is based on the observations/data collected during manufacturing of three consecutive batches, which were manufactured as per Batch Manufacturing record for Export Market at Aurobindo Pharma Ltd. Unit-VII, Jadcherla. Samples were collected and analysed as per Process validation protocol. The data & test results of blend at various in-process phases were complied with the specified limits and final blend sample analysis results found to be complying within specifications. This study and results obtained assures that the manufacturing process is reproducible, yielding consistent product, which meets specification

Rheology of Active-Particle Suspensions

We study the interplay of activity, order and flow through a set of coarse-grained equations governing the hydrodynamic velocity, concentration and stress fields in a suspension of active, energy-dissipating particles. We make several predictions for the rheology of such systems, which can be tested on bacterial suspensions, cell extracts with motors and filaments, or artificial machines in a fluid. The phenomena of cytoplasmic streaming, elastotaxis and active mechanosensing find natural explanations within our model.Comment: 3 eps figures, submitted to Phys Rev Let

Fabrication and characterization of Er+3 doped SiO2/SnO2 glass-ceramic thin films for planar waveguide applications

Glass-ceramics are a kind of two-phase materials constituted by nanocrystals embedded in a glass matrix and the respective volume fractions of crystalline and amorphous phase determine the properties of the glass-ceramics. Among these properties transparency is crucial in particular when confined structures, such as, dielectric optical waveguides, are considered. Moreover, the segregation of dopant rare-earth ions, like erbium, in low phonon energy crystalline medium makes these structures more promising in the development of waveguide amplifiers. Here we are proposing a new class of low phonon energy tin oxide semiconductor medium doped silicate based planar waveguides. Er3+ doped (100-x) SiO2- xSnO2 (x= 10, 20, 25 and 30mol%), glass-ceramic planar waveguide thin films were fabricated by a simple sol-gel processing and dip coating technique. XRD and HRTEM studies indicates the glass-ceramic phase of the film and the dispersion of ~4nm diameter of tin oxide nanocrystals in the amorphous phase of silica. The spectroscopic assessment indicates the distribution of the dopant erbium ions in the crystalline medium of tin oxide. The observed low losses, 0.5±0.2 dB/cm, at 1.54 ?m communication wavelength makes them a quite promising material for the development of high gain integrated optical amplifiers

Sustain-Release of Various Drugs from Leucaena Leucocephala Polysaccharide

This study examines the sustained release behavior of both water-soluble (acetaminophen, caffeine, theophylline and salicylic acid) and water-insoluble (indomethacin) drugs from Leucaena leucocephala seed Gum isolated from Leucaena leucocephala kernel powder. It further investigates the effect of incorporation of diluents like microcrystalline cellulose and lactose on release of caffeine and partial cross-linking of the gum (polysaccharide) on release of acetaminophen. Applying exponential equation, the mechanism of release of soluble drugs was found to be anomalous. The insoluble drug showed near case II or zero-order release mechanism. The rate of release was in the decreasing order of caffeine, acetaminophen, theophylline, salicylic acid and indomethacin. An increase in release kinetics of drug was observed on blending with diluents. However, the rate of release varied with type and amount of blend in the matrix. The mechanism of release due to effect of diluents was found to be anomalous. The rate of release of drug decreased on partial cross-linking and the mechanism of release was found to be super case II