Patient characteristics stratified by TB stigma, TB knowledge, and HIV knowledge.

<p>TB, tuberculosis; HIV, human immunodeficiency virus; CD4, CD4+ T-lymphocyte.</p>a<p>Those with available results only.</p>b<p>Patients who had extra-pulmonary TB other than peripheral lymphatic TB or had all of the following characteristics: self-reported weight loss >10% of body weight, coughing up blood, difficulty breathing in past 4 weeks before TB diagnosis, and cavitary TB or >1/3 involvement of either lung at the initial evaluation.</p>c<p>Patients who reported having a cough lasting greater than one month before TB diagnosis or had other symptoms that lasted longer than 14 days and self-assessed these symptoms as being severe.</p>d<p>High TB stigma defined as TB stigma score ≥1; low TB knowledge defined as TB knowledge score<5; and low HIV knowledge defined as HIV knowledge score<5.</p

Bivariable and multiple logistic regression analyses of predictors for having low TB knowledge^a among HIV-infected TB patients.

<p>TB, tuberculosis; HIV, human immunodeficiency virus; OR, odds ratio; AOR, adjusted odds ratio; CI, confidence interval; CD4, CD4+ T-lymphocyte; variables for which p≤0.20 in bivariable analyses and potential confounders were included in multiple logistic regression analysis.</p>a<p>TB knowledge score<5; TB knowledge score is a summary score of the number of TB knowledge questions (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006360#pone-0006360-t002" target="_blank">table 2</a> - each question is worth 1 point) that a patient correctly answered.</p>b<p>Compared with being treated in Bangkok.</p>c<p>Patients who had extra-pulmonary TB other than peripheral lymphatic TB or had all of the following characteristics: self-reported weight loss >10% of body weight, coughing up blood, difficulty breathing in past 4 weeks before TB diagnosis, and cavitary TB or >1/3 involvement of either lung at the initial evaluation.</p

Baseline TB stigma, TB knowledge, and HIV knowledge among HIV-infected TB patients in Thailand.

<p>TB, tuberculosis; HIV, human immunodeficiency virus; AIDS, acquired immunodeficiency syndrome.</p>a<p>Those with available answers.</p>b<p>Five hundred patients had high TB stigma; 75 did not respond to one or more TB stigma questions.</p>c<p>One hundred and seventy-seven had low TB knowledge; 171 did not respond to one or more TB knowledge questions.</p>d<p>Three hundred and seventy-nine patients had low HIV knowledge; 69 did not respond to one or more HIV knowledge questions.</p

Bivariable and multiple logistic regression analyses of predictors for having low HIV knowledge^a among HIV-infected TB patients.

<p>TB, tuberculosis; HIV, human immunodeficiency virus; OR, odds ratio; AOR, adjusted odds ratio; CI, confidence interval; variables for which p≤0.20 in bivariable analyses and potential confounders were included in multiple logistic regression analysis.</p>a<p>HIV knowledge score<5; HIV knowledge score is a summary score of the number of HIV knowledge questions (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006360#pone-0006360-t002" target="_blank">table 2</a> - each question is worth 1 point) that a patient correctly answered.</p>b<p>Compared with being treated in Bangkok.</p>c<p>Patients who had extra-pulmonary TB other than peripheral lymphatic TB or had all of the following characteristics: self-reported weight loss >10% of body weight, coughing up blood, difficulty breathing in past 4 weeks before TB diagnosis, and cavitary TB or >1/3 involvement of either lung at the initial evaluation.</p

Bivariable and multiple logistic regression analyses of predictors for having high TB stigma^a among HIV-infected TB patients.

<p>TB, tuberculosis; HIV, human immunodeficiency virus; OR, odds ratio; AOR, adjusted odds ratio; CI, confidence interval; variables for which p≤0.20 in bivariable analyses and potential confounders were included in multiple logistic regression analysis.</p>a<p>TB stigma score ≥1; TB stigma score is a summary score of the number of TB stigma questions (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006360#pone-0006360-t001" target="_blank">Table 1</a>; each question was worth 1 point) that a patient answered consistent with stigma.</p>b<p>Compared with being treated in Bangkok.</p>c<p>Patients who had extra-pulmonary TB other than peripheral lymphatic TB or had all of the following characteristics: self-reported weight loss >10% of body weight, coughing up blood, difficulty breathing in past 4 weeks before TB diagnosis, and cavitary TB or >1/3 involvement of either lung at the initial evaluation.</p

Implementing an isoniazid preventive therapy program for people living with HIV in Thailand

<div><p>Treatment of people living with HIV (PLHIV) with latent tuberculosis (TB) infection using isoniazid preventive therapy (IPT) can reduce the risk of TB disease, however, the scale-up of IPT among PLHIV in Thailand and worldwide has been slow. To hasten the implementation of IPT in Thailand, we developed IPT implementation training curricula and tools for health care providers and implemented IPT services in seven large government hospitals. Of the 659 PLHIV enrolled, 272 (41.3%) reported symptoms of TB and 39 (14.3% of those with TB symptoms) were diagnosed with TB. A total of 346 (52.4%) participants were eligible for IPT; 318 (91.9%) of these participants opted to have a tuberculin skin test (TST) and 52 (16.3% of those who had a TST) had a positive TST result. Among the 52 participants with a positive TST, 46 (88.5%) initiated and 39 (75.0%) completed 9 months of IPT: physicians instructed three participants to stop IPT, two participants were lost to follow-up, one chose to stop therapy, and one developed TB. IPT can be implemented among PLHIV in Thailand and could reduce the burden of TB in the country.</p></div

Results of generalized estimating equations logistic regression analysis of baseline characteristics of 316 people living with HIV who had a tuberculin skin test (TST) to determine predictors of a positive TST result (≥5mm of induration).

<p>Results of generalized estimating equations logistic regression analysis of baseline characteristics of 316 people living with HIV who had a tuberculin skin test (TST) to determine predictors of a positive TST result (≥5mm of induration).</p

Characteristics of pulmonary TB patients eligible for analysis, stratified by type of observer during first two months of TB treatment.

*<p>Mobile was defined as not living in the same district for at least three of the past six months.</p>#<p>MTB denotes <i>Mycobacterium tuberculosis</i>, and NTM denotes non-tuberculous mycobacteria.</p>@<p>Patients who were on treatment, but had missing data about whether their sputum smears were positive or negative.</p

Results of generalized estimating equations logistic regression analysis of characteristics of people living with HIV with tuberculosis symptoms^* to control for site-level clustering and to determine predictors of TB disease diagnosis at seven hospitals in Thailand, 2010–2011.

<p>Results of generalized estimating equations logistic regression analysis of characteristics of people living with HIV with tuberculosis symptoms^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0184986#t002fn002" target="_blank">*</a>} to control for site-level clustering and to determine predictors of TB disease diagnosis at seven hospitals in Thailand, 2010–2011.</p

Participant flow.

<p>Participant flow.</p