1 research outputs found
Antinephrolithiatic Potential of Macrotyloma uniflorum Aqueous Extract in Rats
Urolithiasis is a major health problem with its high morbidity, high cost of
management and potential for end-stage renal disease. The aim of our
study is to cure and prevent the recurrent stone formation. Herbal drugs
claim many promising remedies in urolithiasis. An attempt is made in this
direction in the current work by using Macrotyloma uniflorum. The
experimental model selected for the present study is subcutaneous
administration of gentamicin (40mg/kg/day) for 8 days and dietary
supplementation with 5% ammonium oxalate starting at day 5 of the
treatment regimen to induce calcium oxalate urolithiasis. On administration
of aqueous extract of Macrotyloma uniflorum in preventive and curative
groups, moderate to few crystals are observed along the mild appearance
of edema and dilation in tubules and crystals are present focally indicating
the ability of aqueous extract of Macrotyloma uniflorum to dissolve the preformed
stones. The parameters monitored in the present study are Kidney
weight, calcium and oxalate deposition in kidney and the histological
studies support the calcium and oxalate deposition data in kidney. Thus
aqueous extract of Macrotyloma uniflorum showed significant
antinephrolithiatic activity