15 research outputs found
Mo1029 - Inflammatory Biomarkers as Predictors of Mucosal Healing in Patients with Celiac Disease
A proton induced conformational change in metal complexes with potential hydrogen bonding triplet motifs
Biguanide-like bidentate ligands in a variety of transition metal complexes of different geometries exhibit conformational changes upon protonation/deprotonation that alter their capacity to recognise complementary hydrogen bonding motifs.\u
Delays in colonoscopy start time are associated with reductions in adenoma detection rates
Tu1076 Quality of Life in Patients With Celiac Disease Detected by Screening vs. Celiac Disease Detected by Symptoms
Mo1035 - Iron-Deficiency Anemia and Prevalence of Celiac Disease - A Systematic Review with Meta-Analysis
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Endoscopic ultrasound-guided gallbladder drainage as a rescue therapy for unresectable malignant biliary obstruction: a multicenter experience
Abstract
Background
Endoscopic retrograde cholangiopancreatography (ERCP) is often unsuccessful in patients with duodenal stenosis or malignant ampullary infiltration. While endoscopic ultrasound-guided biliary drainage (EUS-BD) has been proposed as an alternative, EUS-guided gallbladder drainage (EUS-GBD) is an attractive option when both approaches fail. We aimed to assess the effectiveness and safety of EUS-GBD as rescue therapy for malignant distal bile duct obstruction.
Methods
A multicenter retrospective study was performed on patients with unresectable malignant distal bile duct obstruction who underwent EUS-GBD between 2014 and 2019 after unsuccessful ERCP and EUS-BD. Clinical success was defined as a decrease in serum bilirubin of > 50 % within 2 weeks.
Results
28 patients were included, with a lumen-apposing metal stent used in 26 (93 %) and a self-expandable metal stent in two (7 %). The technical success rate was 100 %. The clinical success rate was 93 %, with an improvement in bilirubin (7.3 [SD 5.4] pre-procedure vs. 2.8 [SD 1.1] post-procedure;
P
= 0.001). Delayed adverse events included food impaction of the stent (n = 3), with a further two patients developing cholecystitis and bleeding.
Conclusion
This study demonstrates the feasibility of gallbladder drainage to relieve malignant distal bile duct obstruction in patients with failed ERCP and EUS-BD