Solitons explore the quantum classical boundary

It is an open fundamental question how the classical appearance of our environment arises from the underlying quantum many-body theory. We propose that the quantum-classical boundary can be probed in collisions of bright solitons in Bose-Einstein condensates, where thousands of atoms form a large compound object at ultra cold temperatures. We show that these collisions exhibit intricate many-body quantum behavior, invalidating mean field theory. Prior to collision, solitons can loose their well defined quantum phase relation through phase diffusion, essentially caused by atom number fluctuations. This dephasing should typically render the subsequent dynamics more classical. Instead, we find that it opens the door for a tremendous proliferation of mesoscopic entanglement: After collision the two solitons find themselves in a superposition state of various constituent atom numbers, positions and velocities, in which all these quantities are entangled with those of the collision partner. As the solitons appear to traverse the quantum-classical boundary back and forth during their scattering process, they emerge as natural probe of mesoscopic quantum coherence and decoherence phenomena.Comment: 6 pages, 4 figure

Hyper-entangling mesoscopic bound states

We predict hyper-entanglement generation during binary scattering of mesoscopic bound states, solitary waves in Bose-Einstein condensates containing thousands of identical Bosons. The underlying many-body Hamiltonian must not be integrable, and the pre-collision quantum state of the solitons fragmented. Under these conditions, we show with pure state quantum field simulations that the post-collision state will be hyper-entangled in spatial degrees of freedom and atom number within solitons, for realistic parameters. The effect links aspects of non-linear systems and quantum-coherence and the entangled post-collision state challenges present entanglement criteria for identical particles. Our results are based on simulations of colliding quantum solitons in a quintic interaction model beyond the mean-field, using the truncated Wigner approximation.Comment: 6 figure

THERAPEUTIC EFFECTS AND ADVERSE EVENTS OF SINGLE DOSE OF INTRAVITREAL TRIAMCINOLONE ACETONIDE INJECTION IN MACULAR EDEMA

Objective: The objective of the study was to study the therapeutic effects and adverse events of single dose of intravitreal triamcinolone acetonide (TA) in macular edema (ME). Methods: This prospective observational study was conducted for a period of 18 months in a tertiary care hospital. A total of 100 patients who received intravitreal injection of TA 4 mg were followed up within 1 month of injection and thereafter monthly for 3 months. Therapeutic effect was noted by improvement in visual acuity and reduction in macular thickness. Safety was assessed based on adverse events reported during the study period. The quantitative variables were analyzed by paired t-test and the qualitative variables by Wilcoxon signed-rank test and Chi-square test. Results: The mean age was 58.66±11.21 years with majority of patients (46%) in 46–60 age group. Diabetic retinopathy was the most common etiology. Fifteen patients experienced improvement in vision within 1 month, 51, 84, and 91 patients had better visual acuity after 1, 2, and 3 months, respectively, which were statistically significant (p=0.001). The mean macular thickness of 497.79±115.08 at baseline reduced to 448.62±112.48 within 1 month which further reduced to 383.72±105.79, 327.33±86.49, and 263.83±68.68 at the end of the 1st, 2nd, and 3rd months, respectively (p=0.001). The adverse events of rise in intraocular pressure, cataract, redness, pain, floaters, and subconjunctival hemorrhage were not found to be statistically significant (p>0.05). Conclusion: Intravitreal TA injection may be an effective and safe treatment option for ME due to various etiologies

Activation of microglia in acute hippocampal slices affects activity-dependent long-term potentiation and synaptic tagging and capture in area CA1

10.1016/j.nlm.2019.107039NEUROBIOLOGY OF LEARNING AND MEMORY16

Identification, ontogeny and expression analysis of a novel laboratory of genetics and physiology 2 (LGP2) transcript in Asian seabass, Lates calcarifer

Not AvailableLGP2 (laboratory of genetics and physiology 2) is an important member of the retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), which plays a significant role in antiviral innate immunity. In this study, we have cloned the full-length cDNA sequence of LGP2 from Asian seabass, Lates calcarifer (AsLGP2).The complete AsLGP2 cDNA sequence consisted of 2586 nucleotides encoding a putative protein of 681 aminoacids with a molecular mass of 77.6 kDa .From the AsLGP2 protein,four different conserved domains were predicted: a DExDc (DEAD/DEAH box helicase domain), a bacterial type III restriction enzyme domain (RES III), a HELICc Helicase superfamily c-terminal domain and a RIG-I_C-RD (RIG-I C terminal regulatory domain). The transcript of AsLGP2 could be detected in all the 11 tissues tested in healthy animals with high expression noticed in tissues facing external environment such as gill,hindgut and skin.The ontogenic expression profile of AsLGP2 implies a possible maternal transfer of this gene as it has been detected in all early embryonic developmental stages along with unfertilized eggs. Viral analogue, poly I:C, injection resulted in rapid up-regulated expression in different tissues with the highest modulation of expression observed in kidney followed by liver and gill. A rapid response of AsLGP2 expression was also observed in the different tissues of Vibrio alginolyticus-injected L. calcarifer, while significant change in expression was noticed following Staphylococcus aureus infection. Similarly, exposure to different pathogen-mimicking microbial analogues such as polyI:C,LPS and PGN resulted in enhanced expression of AsLGP2 in SISK cell-line. Taking together, these observations suggest that AsLGP2 can act as both antiviral and anti bacterial cytosolic receptor and may play a significant role in embryonic and larval development in marine euryhaline teleosts like Asian seabass.Not Availabl

COMPARISON OF EFFICACY OF TAMSULOSIN, ALFUZOSIN AND SILODOSIN IN THE MANAGEMENT OF BENIGN PROSTATIC HYPERPLASIA: The efficacy of Tamsulosin, Silodosina and Alfuzosin in the management of Benign prostatic hyperplasia is compared and the adverse drug reactions if any, is recorded.

Objectives: This study was done to determine the efficacy of alpha-1 adrenoceptor blockers like Tamsulosin, Alfuzosin and Silodosin in patients with Lower Urinary Tract Symptoms (LUTS) due to Benign Prostatic Hyperplasia (BPH) over 6 months by assessing change in International Prostate Symptom Score (IPSS), quality of life scale for urinary symptoms (Bother score) and improvement in peak urine flow rate (Qmax) from baseline. We also tried to identify any adverse drug reactions (ADR) caused by these drugs. Methods: A prospective observational study was conducted in 291 patients with LUTS secondary to BPH attending Urology outpatient department of a tertiary care centre for a period of 1 year. Ninety-Seven patients in each group received Tamsulosin, Alfuzosin or Silodosin once daily. IPSS, Qmax and the quality of life scale for urinary symptoms by Bother score was assessed at first, third and sixth month of treatment period. ADR was noted and recorded in ADR reporting form. Results: IPSS, mean bother score and mean Qmax showed significant improvement from the baseline in each follow up visit at 1, 3 and 6 months for all the 3 groups; but maximum was for Alfuzosin and was found to be statistically significant (p<0.001). Two patients developed adverse drug reaction during the study; asthenia in Tamsulosin group and hypotension in Silodosin group.  Conclusion: Patients on Alfuzosin showed maximum improvement in the values of IPSS, Bother score and Qmax in BPH patients as compared to Tamsulosin and Silodosin. Alfuzosin would be a better choice in the treatment of LUTS due to BPH

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