MOLECULAR DOCKING STUDY OF NATURALLY OCCURRING COMPOUNDS AS INHIBITORS OF COVID -19

Objectives: The worldwide spread of COVID-19 is an emergent issue to be tackled. Currently, several works in various field have been made in rather short period. The present study aimed to assess bioactive compounds found in medicinal plants as potential COVID-19 Mpro inhibitors using molecular docking study. Methods: The docking analyses were performed by using Autodock, Discovery Studio Visualiser and Igemdock. Results: The binding energy obtained from the docking of 6LU7 with native ligand cupressuflavone is -8.9 kcal/mol. Conclusion: These findings will provide the opportunities to identify the right drug to combat COVID-19

Minimizing the Cost and Enhancing the Security for Cloud Hosting Service

Cloud computing is a new emerging technology which provides different kinds of services through internet and reduces maintenance cost as well as provides data reliability. Now a days many cloud service providers are providing services with different policies and prices. But it leads difficult to customers to choose cloud services with less price. That clients as a rule put their information into a single cloud and after that just trust to luckiness. Proposing new data hosting technique termed as CHARM which supports two strong functionalities.The first is selecting a few suitable clouds and a fitting excess system to store information with minimized financial expense and ensured accessibility.The second is setting off a move procedure to re-disperse information as indicated by the varieties of information access example and evaluating of clouds.In this project defining secret sharing algorithm to reduce the risk of data intrusion and the loss of service availability in the cloud and ensure data integrity. Finally proposed scheme not only saves the cost and also Maintains data and price adjustments

Collective Action for Integrated Community Watershed Management in Semi-Arid India: Analysis of Multiple Livelihood Impacts and the Drivers of Change

Spatial and temporal attributes of watersheds and associated market failures require institutional arrangements for coordinating use and management of natural resources. Effective collective action (CA) for watershed management has the potential to provide multiple economic and environmental benefits - tangible and non-tangible - to rural communities. This allows smallholder farmers to jointly invest in management practices that provide collective benefits to community members. The functions of the group can also extend to include provision of new services like collective marketing of products and essential inputs. While watershed management contributes to resource productivity and sustainability, increased commercialization and market access open opportunities to diversify into high-value crops, creating incentives for agricultural intensification. However, evaluating the multi-faceted impacts of integrated watershed management interventions is complicated by problems of measurement, valuation and attribution. While, more rigorous methods for evaluating such impacts in the context of developing countries are beginning to emerge, this study employs a mix of qualitative and quantitative methods for evaluating these multi-faceted impacts from a case study of a watershed project in semi-arid India. Results from qualitative insights are confirmed through econometric analyses and empirical measurements using proper count erfactuals. The study analyses the drought mitigation, economic and environmental gains along with linked benefits for commercialization of production and increased farmer participation in markets.Resource /Energy Economics and Policy,

Wideband Acoustic Immittance in Children

As wideband absorbance (WBA) gains popularity, it is essential to understand the impact of different middle ear pathologies on the absorbance patterns as a function of frequency in children with various middle ear pathologies. More recently, the use of wideband tympanometry has enabled clinicians to conduct WBA at ambient pressure (WBA amb) as well as the pressurized mode (WBA TPP). This article reviews evidence for the ability of WBA measurements to accurately characterize the normal middle ear function across a wide range of frequencies and to aid in differential diagnosis of common middle ear disorders in children. Absorbance results in cases of otitis media with effusion, negative middle ear pressure, Eustachian tube malfunction, middle ear tumors, and pressure equalization tubes will be compared to age-appropriate normative data. Where applicable, WBA ambas well as WBA TPPwill be reviewed in these conditions. The main objectives of this article are to identify, assess, and interpret WBA amband WBA TPPoutcomes from various middle ear conditions in children between the ages of 3 and 12 years

A Sustainable Community-Based Model of Noncommunicable Disease Risk Factor Surveillance (Shraddha-Jagrithi Project): Protocol for a Cohort Study

Background: India has a massive noncommunicable disease (NCD) burden, at an enormous cost to the individual, family, society, and health system at large, despite which prevention and surveillance are relatively neglected. If diagnosed early and treated adequately, risk factors for atherosclerotic cardiovascular disease would help decrease the mortality and morbidity burden. Surveillance for NCDs, creating awareness, positive lifestyle changes, and treatment are the proven measures known to prevent the progression of the disease. India is in a stage of rapid epidemiological transition, with the state of Kerala being at the forefront, pointing us towards likely disease burden and outcomes for the rest of the country in the future. A previous study done by the same investigators in a population of >100,000 revealed poor awareness, treatment of NCDs, and poor adherence to medicines in individuals with CVD. / Objective: This study aimed at assessing a sustainable, community-based surveillance model for NCDs with corporate support fully embedded in the public health system. / Methods: Frontline health workers will check all individuals in the target group (≥age 30 years) with further follow-up and treatment planned in a “spoke and hub” model using the public health system of primary health centers as spokes to the hubs of taluk or district hospitals. All data entry done by frontline health workers will be on a tablet PC, ensuring rapid acquisition and transfer of participant health details to primary health centers for further follow-up and treatment. / Results: The model will be evaluated based on the utilization rate of various services offered at all tier levels. The proportions of the target population screened, eligible individuals who reached the spoke or hub centers for risk stratification and care, and community-level control for hypertension and diabetes in annual surveys will be used as indicator variables. The model ensures diagnosis and follow-up treatment at no cost to the individual entirely through the tiered public health system of the state and country. / Conclusions: Surveillance for NCDs is an essential facet of health care presently lacking in India. Atherosclerotic cardiovascular disease has a long gestation period in progression to the symptomatic phase of the disease, during which timely preventive and lifestyle measures would help prevent disease progression if implemented. Unfortunately, several asymptomatic individuals have never tested their plasma glucose, serum lipid levels, or blood pressure and are unaware of their disease status. Our model, implemented through the public health system using frontline health workers, would ensure individuals aged≥30 years at risk of disease are identified, and necessary lifestyle modifications and treatments are given. In addition, the surveillance at the community level would help create a general awareness of NCDs and lead to healthier lifestyle habits. / Trial Registration: Clinical Trial Registry India CTRI/2018/07/014856; https://tinyurl.com/4saydnxf / International Registered Report Identifier (IRRID): DERR1-10.2196/2729

Impact of Watershed Management on Women and Vulnerable Groups: Proceedings of the Workshop on Comprehensive Assessment of Watershed Programs in India, 25 July 2007

Watershed programs are recognized as potential engines for agricultural growth and sustainable development in rain-fed areas. Success and sustainability of watershed programs are directly related to collective action for conserving natural resources to enhance crop productivity, livelihoods for sustainable income development and gender equity. Women are key players as managers and direct actors in managing natural resources in the watershed and addressing the household food security. However, often they have passive role in decision-making process because of their low educational levels, social customs, and economic dependenc

Unlocking the Potential of Rainfed Agriculture Through Integrated Watershed Management

Rainfed systems!! globally account for 58 per cent of the world food production (Rosegrant et al., 2002) and accounts for about twothirds of total cropped area and generate nearly half of the total value of agricultural output In India (Kerr, 1996). Because of raintall variability, accelerating land degradation, lack of appropriate technologies, and limited economic investments, the productivity of rainted systems has been quite low. Hence, the relative share and severity of poverty is often higher in rainted regions (Ryan and Spencer, 2001). Addressing the problems of natural resource degradation...........

Application of multiple linear regression and machine learning algorithms to elucidate the association of poor glycemic control and hyperhomocysteinemia with microalbuminuria

Microalbuminuria is an early biomarker of general vascular dysfunction and a predictor of risk for cardiovascular and renal diseases. It is also considered as a marker of insulin resistance in both diabetic and non-diabetic patients. The rationale of this study was to elucidate threshold values of fasting blood glucose (FBS) and glycosylated hemoglobin (HbA1c) that are associated with microalbuminuria. In the parallel association of microalbuminuria with hyperhomocysteinemia was investigated. Machine learning algorithm and multiple linear regression were applied to study the association of poor glycemic control on microalbuminuria and hyperhomocysteinemia. In non-diabetic subjects with FBS <102 mg/dL and HbA1c <6.3%; and in diabetic subjects with good glycemic control (FBS: 102-118 mg/dL; HbA1c: 6.3-7.0%), urinary microalbumin levels were <40µg/mg creatinine. Poor glycemic control (FBS >172 mg/dL and HbA1c >9.0%) was associated with microalbumin >40µg/mg creatinine. Age, gender, HbA1c and FBS were shown to explain variability in urinary microalbumin to the extent of 54.4% as shown by multiple linear regression model. Analysis of variance (ANOVA) revealed higher levels of FBS (F: 39.77, P <0.0001), HbA1c (F: 64.31, P <0.0001) and total plasma homocysteine (F: 3.69, P =0.04) in microalbuminuria and clinical microalbuminuria groups when compared to subjects with normal microalbumin levels. Diabetic patients with poor glycemic index had a more B12 deficiency. Poor glycemic index and hyperhomocysteinemia were associated with clinical microalbuminuria

Potential yield losses caused by the adults of Schizonycha ruficollis on pomegranate (Punica granatum) flowers

Pomegranate is an important fruit crop that is capturing international attention for its rich antioxidants and nutraceutical value. The demand for the fruit is rapidly increasing in major national and international markets. Therefore, any serious pest is of great importance and here we report the severe incidence of adult beetles of Schizonycha ruficollis that resulted in potential yield loss due to its feeding on pomegranate flowers in Devanahalli, Karnataka. Usually June/July adult beetle emerge and feed on hosts like neem and Melia rubra which the farmers plant them as wind breaks along the borders. These attract the beetles into pomegranate field and the pomegranate flowers are then infested by the adult beetles. The pomegranate on an average possess 223 female flowers per tree, which when damaged fails to set fruits causing economic loss. A documentation study during 2023 was taken up to evaluate the crop loss caused by S. ruficollis in pomegranate resulted in potential seven percent yield loss accounting to ₹ 53215/acre at the farm gate price. This loss can be avoided by initiating a management practice at the first site of the beetles especially after the first monsoon rain. This study also helped us to alert pomegranate exporters and extension officials about the need of preventive measures to avoid the yield loss