Synthesis, spectral characterization, and evaluation of antimicrobial activity of <i>O,O</i>′-alkanediyl <i>S</i>-(<i>N</i>-phthalimidomethyl) dithiophosphates and zinc bis(<i>O,O</i>′-alkanediyl) dithiophosphates

<p>The synthesis of novel dithiophosphate derivatives has been achieved. Two <i>O,O′</i>-alkanediyl <i>S</i>-(<i>N</i>-phthalimidomethyl) dithiophosphates and two Zinc bis(<i>O,O′</i>-alkanediyl) dithiophosphates are synthesized by an easy and facile chemical synthetic route. Zinc bis[<i>O,O′</i>-(2-methylpentane-2,4-diyl) dithiophosphate] <b>L¹</b>, Zinc bis[<i>O,O′</i>-(2-ethylhexane-1,3-diyl) dithiophosphate] <b>L²</b>, <i>O,O′</i>-(2-methylpentane-2,4-diyl) <i>S</i>-(<i>N</i>-phthalimidomethyl) dithiophosphate <b>L³</b> and <i>O,O′</i>-(2-ethylhexane-1,3-diyl) <i>S</i>-(<i>N</i>-phthalimidomethyl) dithiophosphate <b>L⁴</b> are synthesized from the respective ammonium salts. Compounds <b>L¹</b>, <b>L²</b>, <b>L³</b>, and <b>L⁴</b> are characterized by (CHN) elemental analysis, ESI mass, FT-IR, ¹H, ¹³C, and ³¹P NMR techniques. The crystal structure of ammonium <i>O,O′</i>-(2-methylpentane-2,4-diyl) dithiophosphate is discussed. <b>L¹</b>, <b>L²</b>, <b>L³</b>, and <b>L⁴</b> were evaluated for antimicrobial activity. It was found that the phthalimide derivatives <b>L³</b> and <b>L⁴</b> showed much better antifungal potential against some species of fungus. The Zinc dithiophosphates <b>L¹</b> and <b>L²</b> showed good antibacterial activity against <i>Bacillus cereus</i> and <i>Escherichia coli</i>.</p