Computational simulation of biaxial fatigue behaviour of lotus-type porous material

A computational simulation of low-cycle fatigue behaviour of lotus-type porous material, subjected to biaxial in-phase loading cycles is presented in this paper. Fatigue properties of porous materials are less frequently published in the literature. This paper evaluates computational analyses, where different pore distribution and biaxial loading conditions in relation to the pore orientations is considered in each simulation. The fatigue analysis is performed by using a damage initiation and evolution law based on the inelastic strain energy. The computational results are subjected to the appropriate statistical analysis, because of different pore topology a different fatigue lives are obtained on the same loading level. Results of computational simulations show also a qualitative understanding of porosity influence on low-cycle fatigue failures of lotus-type porous material under biaxial loading conditions

Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16

A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan, Hugot et al. (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel disease in a small proportion of families. Subsequent work has suggested that this localization is important for susceptibility to Crohn's disease rather than ulcerative colitis (Ohmen et al. 1996; Parkes et al. 1996). We investigated the contribution of this localization to the inheritance of inflammatory bowel disease in 54 multiplex Australian families, and confirmed its importance in a significant proportion of Crohn's disease families; we further refined the localization to a region near to D16S409, obtaining a maximum LOD score of 6.3 between D16S409 and D16S753