Magneto-immutable turbulence in weakly collisional plasmas

We propose that pressure anisotropy causes weakly collisional turbulent plasmas to self-organize so as to resist changes in magnetic-field strength. We term this effect "magneto-immutability" by analogy with incompressibility (resistance to changes in pressure). The effect is important when the pressure anisotropy becomes comparable to the magnetic pressure, suggesting that in collisionless, weakly magnetized (high-$\beta$) plasmas its dynamical relevance is similar to that of incompressibility. Simulations of magnetized turbulence using the weakly collisional Braginskii model show that magneto-immutable turbulence is surprisingly similar, in most statistical measures, to critically balanced MHD turbulence. However, in order to minimize magnetic-field variation, the flow direction becomes more constrained than in MHD, and the turbulence is more strongly dominated by magnetic energy (a nonzero "residual energy"). These effects represent key differences between pressure-anisotropic and fluid turbulence, and should be observable in the $\beta\gtrsim1$ turbulent solar wind.Comment: Accepted for publication in J. Plasma Phy

Amplitude limits and nonlinear damping of shear-Alfvén waves in high-beta low-collisionality plasmas

This work, which extends Squire et al (Astrophys. J. Lett. 2016 830 L25), explores the effect of self-generated pressure anisotropy on linearly polarized shear-Alfvén fluctuations in low-collisionality plasmas. Such anisotropies lead to stringent limits on the amplitude of magnetic perturbations in high-β plasmas, above which a fluctuation can destabilize itself through the parallel firehose instability. This causes the wave frequency to approach zero, 'interrupting' the wave and stopping its oscillation. These effects are explored in detail in the collisionless and weakly collisional 'Braginskii' regime, for both standing and traveling waves. The focus is on simplified models in one dimension, on scales much larger than the ion gyroradius. The effect has interesting implications for the physics of magnetized turbulence in the high-β conditions that are prevalent in many astrophysical plasmas

S. A. J. Clark to his Father (23 May 1863)

Regarding a Memphis newspaper report naming killed and wounded; also mentions Jackson, MS, and Vicksburg, MShttps://egrove.olemiss.edu/ciwar_corresp/1546/thumbnail.jp

Mining Extracellular Vesicles for Clinically Relevant Noninvasive Diagnostic Biomarkers in Cancer

Extracellular vesicles (EVs) are nanosized vesicles secreted by virtually all cell types into the extracellular milieu. EVs transport bioactive molecules between cells and play multifaceted roles in cell-to-cell communications and in the pathogenesis of various human diseases including cancer. EVs are currently a focus of intensive interest, mainly because they hold a wealth of biological information in the form of differentially expressed nucleic acids and proteins, including DNA and cancer-related mutated genes, microRNAs, and a variety of transcriptional factors. Both the mutational content and any differentially expressed RNA are highly stable in patient blood or urine because they are encapsulated in EVs. This protects them against nuclease activity, pH change, temperature fluctuations, and multiple free-thaw cycles. Therefore, EVs isolated from patient fluids may serve as an ideal source of liquid biopsy for mining cancer signatures through mutation screening and genetic profiling. However, the methods for obtaining pure and intact EVs from patient samples, as well as the optimized characterization of tumor-derived EVs are still not rigorously defined for routine clinical use. High-throughput genomic or proteomic platforms may aid in the identification of novel diagnostic and prognostic biomarkers that collectively could lead to cancer monitoring and improved patient outcome

Network orchestration in a large inter-organizational project

Multiple organizations working jointly on shared activities in inter-organizational projects for a defined period of time are used increasingly to coordinate the supply of complex products, subsystems, and services across many industries. Despite the growth in inter-organizational networks as an organizational form, scholars have only recently begun to identify how lead organizations orchestrate the coordination of multiple parties with disparate goals, responsibilities, and capabilities. Prior work offers limited insights into the choice of network governance forms, and how coordination is undertaken by the network orchestrator to govern these networks. We conducted a longitudinal study of four networks to deliver vital services into a large project. We identified how the choice of network governance form was based on task complexity. A shared governance form was chosen for networks developed to deliver routine services, whereas a lead organization governance form was chosen for networks set up to deliver complex services. However, findings showed that the selection of an appropriate governance form was not sufficient for ensuring high performance. The network orchestrator's mode of coordination (formal or informal), the intensity of coordination (active or passive), and fit with the form of governance form (shared or lead organization governed) was important in driving performance

Are There Really Cooper Pairs And Persistent Currents in Aromatic Molecules

Over twenty years ago one of us suggested the title was affirmative. In 2012 Cooper pairs were identified in several, but not all aromatic compounds tested, benzene being one. This manuscript discusses the formation of three time-reversed pairs of states forming pseudobosons (high energy Cooper pairs) in benzene at room temperature. The large stabilization in energy that results is the additive effect of energy gaps of an s wave state and a charge density wave permitting the pseudobosons to exist at room temperature. The overall result of these interactions is three pseudobosons occupying the lowest boson state and the positions of the carbon nuclei are optimum by forming a perfect hexagon. The possibility of a persistent current exists; detection might not be easy.Comment: two sections rewritten; additional referenc

The Genetics of Osteosarcoma

Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in children and adolescents relative to other age groups. The etiology of this often aggressive cancer is currently unknown, because complicated structural and numeric genomic rearrangements in cancer cells preclude understanding of tumour development. In addition, few consistent genetic changes that may indicate effective molecular therapeutic targets have been reported. However, high-resolution techniques continue to improve knowledge of distinct areas of the genome that are more commonly associated with osteosarcomas. Copy number gains at chromosomes 1p, 1q, 6p, 8q, and 17p as well as copy number losses at chromosomes 3q, 6q, 9, 10, 13, 17p, and 18q have been detected by numerous groups, but definitive oncogenes or tumour suppressor genes remain elusive with respect to many loci. In this paper, we examine studies of the genetics of osteosarcoma to comprehensively describe the heterogeneity and complexity of this cancer