Nuclear receptors in vascular biology

Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics. In response to these diverse but critically important mediators, nuclear receptors regulate the homeostatic control of lipids, carbohydrate, cholesterol, and xenobiotic drug metabolism, inflammation, cell differentiation and development, including vascular development. The nuclear receptor family is one of the most important groups of signaling molecules in the body and as such represent some of the most important established and emerging clinical and therapeutic targets. This review will highlight some of the recent trends in nuclear receptor biology related to vascular biology

The Interactional bind of 'just [do X]'

This article examines the use of just-formulated advisings in ordinary, naturally occurring sequences of unsolicited advice giving when produced in response to troubles-tellings. Drawing on two examples from our broader collection, we demonstrate that such advisings are employed in response to advice resistance and function to minimize proposed courses of future action, attenuating their imposing nature. We show they place an interactional bind upon advice recipients that contributes toward further resistance. This article explicates this bind and its categorial, epistemic, and moral implications. Data are in American and British English