Prospectus, April 29, 1981

STUGO ELECTIONS, TODAY, TOMORROW -- VOTE!; Notice to Stugo candidates; Parkland College Student Government presents for your entertainment!: George Faber and Stronghold; Karate artist at PC; May Day May 1st.; REO in class by themselves; Mahomet Women\u27s Club sponsors book sale for Mahomet Library; Classifieds; Track team looks strong vs. stern competition: 1600 Relay, Cox, and Patrick take firsts in PC Invite; Softball team eliminated in Sectional, Eye CIAC; Cobras rip Danville twice; Bosch\u27s daring pick gets her the money; Parkland track scoreboard; Good balance up and down the lineuphttps://spark.parkland.edu/prospectus_1981/1018/thumbnail.jp

Prospectus, February 4, 1981

12 RUNNING FOR POSITIONS IN STU GO.; Severns speaks to Community News Class; Sign up for student insurance; $1.50 a gallon? Ouch!: Instructiors discuss oil de-regulation; Everything you always wanted to know about participating in class!; Did you know that?; The Ice Capades \u27celebrates\u27 at the Hall Feb. 10-15; Muddy Waters: Is he the father of Rock n\u27 Roll?; Media 1000$ catches Parkland\u27s eyes!; Ramblin\u27...; Classifieds; Homer has big celebration for their hero: Paul Lewis; 11 Amendments to Stugo Constitution; 250 enrolled in Learning Lab.; It\u27s Susan B. Anthony\u27s b-day!; 42 donated at the Blood Drive; Images getting ready to hit the presses.; Women\u27s team boosts record to 19-1; Cobras beat arch-rival Lake Land; Dunson slam takes game into overtime: Cobras upset No. 1 Kankakee in double OT; Women beat Cavaliers; Softball practice begins Feb. 9; Geoff Ray wins FF competition; Fast Freddy Contest; Collins, the perfect leaderhttps://spark.parkland.edu/prospectus_1981/1028/thumbnail.jp

Prospectus, September 10, 1980

ARE YOU A \u27REAL STUDENT\u27?; Parkland People; Gamut challenges you; Emergency course offered; Oops!; Stugo hopefuls list qualifications; Kinks wow U of I fans; Coates announces student audtions; Country music is moving up; Women\u27s Program offers self-series; Classifieds; Students are....well, just students; Student disappointed; Correction; Science You Can See: Ask not what Cable T.V. can do for you, ask what you can do for Cable T.V.; B-ball deadline is Sept. 22; Football and tennis are IM openers; PC Datebook; Golfers begin season with win over Danville; After some surprises last week, Fast Freddy is ready; LaBadie confident of his runners; Fast Freddy Contest; Bench Warmer: Cobras show talenthttps://spark.parkland.edu/prospectus_1980/1022/thumbnail.jp

Somatic mutations affect key pathways in lung adenocarcinoma

Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well- classified primary tumours. Here we report the results of a collaborative study to discover somatic mutations in 188 human lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high frequencies and thus are probably involved in carcinogenesis. The frequently mutated genes include tyrosine kinases, among them the EGFR homologue ERBB4; multiple ephrin receptor genes, notably EPHA3; vascular endothelial growth factor receptor KDR; and NTRK genes. These data provide evidence of somatic mutations in primary lung adenocarcinoma for several tumour suppressor genes involved in other cancers - including NF1, APC, RB1 and ATM - and for sequence changes in PTPRD as well as the frequently deleted gene LRP1B. The observed mutational profiles correlate with clinical features, smoking status and DNA repair defects. These results are reinforced by data integration including single nucleotide polymorphism array and gene expression array. Our findings shed further light on several important signalling pathways involved in lung adenocarcinoma, and suggest new molecular targets for treatment.National Human Genome Research InstituteWe thank A. Lash, M.F. Zakowski, M.G. Kris and V. Rusch for intellectual contributions, and many members of the Baylor Human Genome Sequencing Center, the Broad Institute of Harvard and MIT, and the Genome Center at Washington University for support. This work was funded by grants from the National Human Genome Research Institute to E.S.L., R.A.G. and R.K.W.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62885/1/nature07423.pd

Modeling Ocean Ecosystems: The PARADIGM Program

The role of the oceans in Earth systems ecology, and the effects of climate variability on the ocean and its ecosystems, can be understood only by observing, describing, and ultimately predicting the state of the ocean as a physically forced ecological and biogeochemical system. This is a daunting but exciting challenge, because the ocean-atmosphere system is dynamically linked, and oceanic habitats are both diverse and complex, providing tremendous variety in environmental conditions and associated life forms. And paradoxically, as we learn more and more about ocean life, for example, through the genomics revolution (Doney et al., 2004), the number of unanswered questions increases.National Oceanographic Partnership Program (U.S.) (NSF/ONR/NOPP grant N000140210370

Modeling ocean ecosystems: The PARADIGM program

THE ROLE OF THE OCEANS in Earth systems ecology, and the effects of climate variability on the ocean and its ecosystems, can be understood only by observing, describing, and ultimately predicting the state of the ocean as a physically forced ecological and biogeochemical system. This is a daunting but exciting challenge, because the ocean-atmosphere system is dynamically linked, and oceanic habitats are both diverse and complex, providing tremendous variety in environmental conditions and associated life forms. And paradoxically, as we learn more and more about ocean life, for example, through the genomics revolution (Doney et al., 2004), the number of unanswered questions increases. Models, be they conceptual, statistical, or numerical simulations, are useful and necessary tools for studying the complex interactions that influence ecosystem structure and function. Originally, a primary function of marine ecosystem models was to help in the development of understanding; also, they were applied in fisheries models to predict the abundance of specific commercial fish stocks. Now, they are being asked to do much more. On local and regional scales, there is growing recognition that management of marine resources and assessment of human perturbations must encompass the whole ecosystem, not individual species. Extending further to basin and global scales, the potential impacts of global change present an immediate challenge, nationally and globally, to define and execute responsive strategies, based to a large extent on the predictions of interdisciplinary global models that must be validated by comparison with measurements. Consequently, the ultimate objective of any comprehensive marine ecosystem modeling program must be the development and implementation of reliable forecast systems, guided by and validated with systematic observations of the sea