Dynamic Radio-Frequency Transverse Susceptibility in Magnetic Nanoparticle Systems

A novel resonant method based on a tunnel-diode oscillator (TDO) is used to study the dynamic transverse susceptibility in a Fe nanoparticle system. The magnetic system consists of an aggregate of nanometer-size core (Au)-shell (Fe) structure, synthesized by reverse micelle methods. Static and dynamic magnetization measurements carried out in order to characterize the system reveal a superparamagnetic behavior at high temperature. The field-dependent transverse susceptibility at radio-frequencies (RF), for different temperatures reveals distinct peak structure at characteristics fields (H_k, H_c) which changes with temperature. It is proposed that relaxation processes could explain the influence of the temperature on the field dependence of the transverse susceptibility on the MI.Comment: 3 pages, 2-column, 3 figures, To be published in J. Appl. Phys. 2000 (44th Annual MMM proceedings

Method of treatment of viral hepatitis C in children with contraindications to standard antiviral therapy

The purpose of the work consists in obtaining the methods of treatment of chronic viral hepatitis C even in a situation when the patients have contraindications to the administration of standard antiviral therapy, and in improving the biochemical parameters and reducing the duration of hospitalization of the children with chronic viral hepatitis C. The presented materials demonstrate the effectiveness of an original method of treatment of viral hepatitis C in the case of high cytolysis associated with unbalanced diabetes, renal decompensation, non-viral autoimmune diseases, epilepsy and other diseases, which have contraindications to the administration of antiviral therapy. The basic therapy has been supplemented by the national phytopreparation Pacovirin in capsules with antiviral, immunomodulatory, antioxidant and interferonogenic activity. The efficacy of Pacovirin has been assessed on the basis of clinical, virological, immunological and biochemical indices. At the same time the analysis and evaluation of the results in the context of modern literature sources concerning the treatment of chronic hepatitis C in children with contraindications to standard antiviral therapy has been performed. The obtained results demonstrate an increased effectiveness of the treatment that is manifested by more rapid normalization of clinical and laboratory indices

Efficiency of the national drug pacovirin in the treatment of infectious mononucleosis in children

National Center of Public Health, the Republic of Moldova, Municipal Infectious Diseases Hospital for Children, Chisinau, Toma Ciorba Hospital of Infectious Diseases, Chisinau, the Republic of MoldovaBackground: In the article are presented the clinical results of the treatment of children with infectious mononucleosis where the basic therapy has been combined with the administration of the local drug pacovirin which has antiviral, immunomodulatory, interferonogenic and antioxidant activity. Material and methods: Pacovirin has been administered for one month by 50 mg capsules 2 times a day per os. The object of study has been presented by 175 patients (84 patients in the experimental group and 91 ones in the comparison group) and the records of the patients surveillance (form 003/e), containing the clinical diagnosis of infectious mononucleosis with Epstein-Barr virus and hepatitis syndrome. The duration of the treatment has been one month, the doses being age-appropriate and applied 2 times a day. Results: The administration of pacovirin as a medicinal remedy in addition to the traditional treatment, in accordance with the method proposed by us, has led to the more intensive normalization of clinical and laboratory indices, decrease of the pathological process and the rapid recovery of the patients, as well as the more intensive normalization of biochemical indices and significant reduction of the duration of the main clinical signs in the experimental group compared with the control group. Conclusions: The drug pacovirin has a positive effect on the main clinical signs of general toxic syndrome and digestive disorders, which have disappeared in a significant number of patients after the treatment. In most patients in the experimental group a decrease in the size of liver and spleen has been observed through palpatory evaluation by the end of the treatment course with pacovirin. In the the experimental group a positive dynamics of paraclinical indices (Alt, AST and γGTP) has been evident

Pelvic floor disorders in gynecological malignancies. An overlooked problem?

Cervical, endometrial, ovarian, vulvar, and vaginal cancers affect women of a broad age spectrum. Many of these women are still sexually active when their cancer is diagnosed. Treatment options for gynecological malignancies, such as gynecological surgery, radiation, and chemotherapy, are proven risk factors for pelvic floor dysfunction. The prevalence of urinary incontinence, fecal incontinence, and sexual dysfunction before cancer treatment is still unclear. Hypotheses have been raised in the literature that these manifestations could represent early symptoms of pelvic cancers, but most remain overlooked even in cancer surviving patients. The primary focus of therapy is always cancer eradication, but as oncological and surgical treatment options become more successful, the number of cancer survivors increases. The quality of life of patients with gynecological cancers often remains an underrated subject. Pelvic floor disorders are not consistently reported by patients and are frequently overlooked by many clinicians. In this brief review we discuss the importance of pelvic floor dysfunction in patients with gynecological malignant tumors

Coinfected HIV/TB diseases – the priority problem of public health

Tuberculosis and HIV infection are the infectious diseases that create major problems in the countries with limited resources. The estimates of the WHO show that more than 9 million of new cases of active TB and nearly 2 million of deaths from tuberculosis [1], and about 3 million of new cases of HIV infection, and 1.8 million of deaths associated with AIDS [2, 3] are recorded annually. Mycobacterium of tuberculosis and HIV co-infection are the factors that create special problems of diagnosis and treatment and put enormous pressure on the health care system. In the past 10 years there has been a considerable increase of the coinfection of TB/HIV in Moldova [4]. The progression of untreated HIV infection can lead to immunodeficiency and increased susceptibility to infections, including tuberculosis. Namely, the HIV epidemic has led to tuberculosis in many countries, especially in sub-Saharan Africa, Asia and South America. TB in the populations with a high prevalence of HIV is a major cause of morbidity and mortality. Therefore, the programs to fight TB and HIV/AIDS are closely linked. HIV prevention should be a priority for TB controlling, in turn, TB prevention and treatment should be a priority of HIV/AIDS programs. Moreover TB and HIV programs provide a support for health care workers in general. The previous programs concerning TB and HIV/AIDS mainly worked through separate directions and activities. However, a new approach to TB control in populations with high HIV prevalence requires an effective collaboration between these programs. In the host body the two pathogens, M. tuberculozis and HIV, reinforce each other (the fact that accelerates the deterioration of the immune function) and may induce a premature death if being untreated. 14 million of people worldwide are estimated to be infected with the both infections [5]. Tuberculosis is a general cause of death of people with AIDS [6], representing approximately 26% of AIDS-related deaths, of which 99% are in developing countries [7]

Evaluation of the influenza, acute respiratory infections and severe acute respiratory infections by the surveillance system in the Republic of Moldova

The article presents a weekly clinical-epidemiological and virological evolution of influenza, acute respiratory infections (ARI) of the upper respiratory tract and severe acute respiratory infections (SARI) in the seasons of 2012-2013. Influenza has been detected mainly in people aged 15 to 64 with its regional distribution and a moderate impact on the health care system. The incidence of influenza in this season has been 7.5 times as much as in the last season. The leading role of the influenza virus A(H1N1)pdm and B with the little involvement of the influenza virus A(H3N2) has been established in the structure of the influenza epidemic. By the antigenic structure, the isolated in the Republic of Moldova influenza viruses have been similar with the influenza viruses strains introduced in the influenza vaccine in 2012-2013 seasons. ARI morbidity beginning from the 40th week of 2012 was increasing, then it slightly reduced in the 1st week of 2013, and again there was its peak in the 8thweek of 2013 followed by a gradual reduction. ARI have been registered in all the regions of Moldova. The highest morbidity level in the country has been registered in Balti and the lowest – in Briceni, affecting mainly the children aged 0 to14. The level of ARI morbidity in the mentioned period has increased the epidemic threshold by 1.5 times in comparison with the same period of the previous season. The SARI morbidity has been registered in all the administrative territories with the highest level of morbidity in Balti and the lowest – in Dubasari, affecting both adults and children. The SARI morbidity level beginning from the 40th week of 2012 was increasing, reaching its peak in the 8thweek of 2013, then it reduced. The SARI morbidity during the evaluated period has been 1.3 times as much as in the same period of the 2011-2012 seasons

Evolution of epidemical process of acute viral hepatitis B, C and D in the context of realization of National Programs for viral hepatitis B, C and D prevention

This scientific article discusses particularities of modern evolution of epidemic process of viral hepatitis B, C and D in the Republic of Moldova. Three national programs for viral hepatitis B, C and D prevention have been implemented in the Republic of Moldova. As a result of the introduction of these programs the morbidity of parenteral viral hepatitis has decreased significantly, but the implementation of all preventive measures is necessary for viral hepatitis diminution. In order to further reduce the incidence of acute viral hepatitis to the indicators registered in most European countries and the incidence of chronic hepatitis, cirrhosis and primary liver cancer, as well as to improve the epidemiological situation and the health status of the population of the Republic of Moldova and to reduce the economic impact the Ministry of Health together with the National Centre of Health has developed a National Program on the fight against viral hepatitis B, C and D for 2012-2016. The materials and results of the research on the epidemiology of viral hepatitis, conducted over a period of many years by the staff of the laboratory of the National Centre of Public Health, have been used. The epidemiological, analytical and statistical methods have been applied in the study