The intramolecular ene reactions of some unsaturated acyloins

The reaction of 3β-tosyloxy-5α-cholesta-5,6β-diol with potassium t butoxide in t-butanol has been further investigated. 5β-Hydroxy-4,5-secocholest-3-en-6-one was synthesised. It was shown to undergo an ene reaction in decalin in a sealed tube at 200°C to give primarily 3β-methyl-A-nor-5β-cholestan-5-o1 -6-one and 6β-hydroxy-4(5-6α) abeo-cholestan-5-one. These primary products were further modified under the reaction conditions to give 3-methyl-B-nor-5β-cholest-2-en-4-one and 5β-cholestan-5-ol-6-one respectively. The cyclohexane analogue, 3-methyl-3-(3-butenyl)-2-hydroxy-cyclohexanl- one was synthesised. Heating under reflux in decalin gave 3β,7aβ-dimethyl- 3aβ-hydroxy-octahydro-4H-inden-4-one;5β,7aβ-dimethyl-3aβ-hydroxy-octahydro- 4H-inden-4-one and an unidentified minor product. The synthesis of 5-(2-propenyl)-5β-cholestan-2-ol-3-one was partially completed. The epimeric 5-(2-propenyl)-5β-cholestan-2-ol-3-one. was synthesised. The ene reaction was observed in refluxing toluene giving 2α,5-(1-methylethano)-5α-cholestan-2β-ol-3-one and 3α,5-(methyethano)-5α-cholestan-3β–ol-2-one. The ketone analogue, 5-(2-propenyl )-5α-cholestan-3-one underwent an ene reaction in decalin in a sealed tube at 250°C to give 2α,5-(1-methylethano) -5α-cholestan-3-one

Fluorescent labeled inhibitors

Provided herein are a series of fluorescently labeled phosphonate and phosphate compounds such as can be used for affinity probes to detect certain enzymes including lipases. Also provided are methods of making and using such compounds. For the most up-to-date information about these patents, including the availability of Certificates of Correction, be sure to check the United States Patent and Trademark Office\u27s free, publicly accessible database: Patent Public Search https://ppubs.uspto.gov/pubwebapp/static/pages/landing.htmlhttps://irl.umsl.edu/patents/1016/thumbnail.jp

Removing Aluminum from Solution Using Chelating Compounds and Immobilized Tethered Chelators

Methods are described for removing aluminum from a solution using novel di- and tripodal compounds as chelators

Chelating Compounds and Immobilized Tethered Chelators

Novel di- and tripodal compounds useful as chelators, intermediates for their production and a method for treating an aqueous solution to remove trivalent metal ions are presented

Chelating Compounds and Immobilized Tethered Chelators

Novel compounds useful as chelators, intermediates for their production and methods for removing trivalent and tetravalent metal ions from solution are presented.https://irl.umsl.edu/patents/1063/thumbnail.jp

Flow-Through Filter to Remove Aluminum from Medical Solutions

A flow through filter assembly includes a trivalent and tetravalent metal ion capturing agent and a flow controller providing a predetermined flow rate which allows capture of the trivalent and tetravalent metal ions by the capturing agent

A Filtration System That Greatly Reduces Aluminum in Calcium Gluconate Injection, USP Used to Prepare Parenteral Nutrition Solutions

OBJECTIVE: The study objective was to reduce aluminum (Al) in Calcium Gluconate Injection, US Pharmacopeia (USP) used in the preparation of parenteral nutrition (PN) solutions. METHODS: A flow-through filter containing an immobilized chelator that complexes Al from Calcium Gluconate Injection, USP as it flows through the filter was designed, refined by design modifications, and extensively tested. When a small-volume parenteral vial containing 100 mL of Calcium Gluconate Injection, USP is connected on the inlet side of the filter, and the outlet side is connected to an evacuated receiving vial, the filtered solution is drawn into the receiving vial. This constitutes a complete system to remove Al from Calcium Gluconate Injection, USP. RESULTS: The extent of Al removal is flow rate dependent. At a flow rate of 1 mL/min approximately 85% of the Al was removed from calcium gluconate solution. PN solutions have been reported to deliver 15 to 23 mcg/kg/day Al to neonates. Given that Calcium Gluconate Injection, USP provides 85% of the Al in neonatal PN solutions, removal of 85% of the Al from this source was calculated to reduce Al delivered to most neonates to \u3c 5 mcg/kg/day. CONCLUSIONS: A point-of-use, self-contained, single-use, disposable, Al-complexing filter has been created. It was calculated to reduce Al delivered in PN solutions by 72%, resulting in daily Al delivery below the level that results in Al accumulation associated with central nervous system and bone toxicity to all but the smallest (\u3c 1 kg) infants

The Chemistry and Biology of Cyclophostin, the Cyclipostins and Related Compounds

Cyclophostin, the cyclipostins and the salinipostins are structurally related cyclic enolphosphate natural products. This mini review describes their isolation, synthesis and biological activities. In addition, the synthesis and biological activities of monocyclic enolphosphate and mono and bicyclic enolphosphonate analogs are presented

The Chemistry and Biology of Cyclophostin, the Cyclipostins and Related Compounds

Cyclophostin, the cyclipostins and the salinipostins are structurally related cyclic enolphosphate natural products. This mini review describes their isolation, synthesis and biological activities. In addition, the synthesis and biological activities of monocyclic enolphosphate and mono and bicyclic enolphosphonate analogs are presented