<i>Chlamydia trachomatis</i> strains identified in this study.

<p>Only single nucleotide polymorphisms and their locations are shown. Reference strains are <i>C. trachomatis</i> HAR 13 (genovar A) (NC_007429) and <i>C. trachomatis</i> M33636 (genovar B). Letters in parenthesis represent the amino acid and any resulting change. Genotype B2 is identical to the reference strain. (VS, variable sequence. CS, conserved sequence.)</p

Comparative ocular <i>C. trachomatis</i> infection status (by Amplicor) before and two months after antibiotic treatment amongst all those tested at both time points.

<p>(+ infected, − not infected).</p

Clinical activity, infection (Amplicor) and genotypes by village and timepoint.

<p>For each village, ‘Examined’ is the number of people examined ‘TF/TI’ is the number of individuals (all ages) with active trachoma, and ‘CT+’ the number of those whose ocular swabs tested positive by Amplicor. The numbers bracketed after the genotype indicate the number of times it appeared: A2 (14) denotes 14 samples contained genotype A2.</p

Frequency of <i>C. trachomatis</i> strains present at baseline and 2 months, subdivided by site of collection. Numbers in parenthesis are %.

<p>Frequency of <i>C. trachomatis</i> strains present at baseline and 2 months, subdivided by site of collection. Numbers in parenthesis are %.</p

Distribution of quantitative PCR determined parasite densities.

<p>pan- <i>Pan plasmodium</i>, Geometric mean values are indicated by horizontal lines. Geometric mean values are for PCR + 1.8 p/μL (range 0.1–770), for PCR+/ pan HTP-LAMP + 2.5 p/μL (range 0.2–770), for PCR+/ pan-HTP-LAMP– 1.4 p/μL (range 0.1–7) and for Chelex pan-LAMP + 3.4 p/μL (range 0.1–770).</p

Flow chart of high-throughput (HTP)-LAMP evaluation.

<p>Results of Pan <i>Plasmodium</i> HTP-LAMP, confirmed PCR and Chelex LAMP (Ch-LAMP) are summarized. spp-species.</p

Characterization of HTP-LAMP positive blood samples (N = 22).

<p>Characterization of HTP-LAMP positive blood samples (N = 22).</p

Diagnostic accuracy of Malaria pan HTP-LAMP compared to PCR for 3008 field samples.

<p>Diagnostic accuracy of Malaria pan HTP-LAMP compared to PCR for 3008 field samples.</p

Detection of LAMP result under UV light.

<p>N- negative, P- positive, NC-negative control, PC- positive control.</p

Characterization of HTP-LAMP versus PCR discordant samples for diagnosis of <i>Plasmodium</i> infection (N = 31).

<p>Characterization of HTP-LAMP versus PCR discordant samples for diagnosis of <i>Plasmodium</i> infection (N = 31).</p