The Genetic Links to anxiety and depression (GLAD) study: Online recruitment into the largest recontactable study of depression and anxiety

Background: Anxiety and depression are common, debilitating and costly. These disorders are influenced by multiple risk factors, from genes to psychological vulnerabilities and environmental stressors, but research is hampered by a lack of sufficiently large comprehensive studies. We are recruiting 40,000 individuals with lifetime depression or anxiety and broad assessment of risks to facilitate future research. Methods: The Genetic Links to Anxiety and Depression (GLAD) Study (www.gladstudy.org.uk) recruits individuals with depression or anxiety into the NIHR Mental Health BioResource. Participants invited to join the study (via media campaigns) provide demographic, environmental and genetic data, and consent for medical record linkage and recontact. Results: Online recruitment was effective; 42,531 participants consented and 27,776 completed the questionnaire by end of July 2019. Participants’ questionnaire data identified very high rates of recurrent depression, severe anxiety, and comorbidity. Participants reported high rates of treatment receipt. The age profile of the sample is biased toward young adults, with higher recruitment of females and the more educated, especially at younger ages. Discussion: This paper describes the study methodology and descriptive data for GLAD, which represents a large, recontactable resource that will enable future research into risks, outcomes, and treatment for anxiety and depression

Odd and even partial waves of f \u3b7\u3c0 12\u3b7\u3c0 12 and \u3b7\u2032\u3c0 12\u3b7\u2032\u3c0 12 in \u3c0 12p\u2192\u3b7(\u2032)\u3c0 12p\u3c0 12p\u2192\u3b7(\u2032)\u3c0 12p at 191 GeV/c

Exclusive production of \u3b7\u3c0 12 and \u3b7 \u3c0 12 has been studied with a 191 GeV/c \u3c0 12 beam impinging on a hydrogen target at COMPASS (CERN). Partial-wave analyses reveal different odd/even angular momentum (L) characteristics in the inspected invariant mass range up to 3 GeV/c2. A striking similarity between the two systems is observed for the L = 2, 4, 6 intensities (scaled by kinematical factors) and the relative phases. The known resonances a2(1320) and a4(2040) are in line with this similarity. In contrast, a strong enhancement of \u3b7 \u3c0 12 over \u3b7\u3c0 12 is found for the L = 1, 3, 5 waves, which carry non-q\uafq quantum numbers. The L = 1 intensity peaks at 1.7 GeV/c2 in \u3b7 \u3c0 12 and at 1.4 GeV/c2 in \u3b7\u3c0 12, the corresponding phase motions with respect to L =2 are different