Efficacy of methylergometrine during the early puerperium: a randomized double-blind placebo-controlled clinical trial

OBJECTIVE: To determine if oral methylergometrine administration during the first 10 d following spontaneous vaginal delivery has any beneficial effect on the increase of hemoglobin levels. METHODS: This was a parallel group double-blind placebo-controlled clinical trial conducted at single center university hospital in Italy. Participants were puerperal women, who delivered singleton gestation with spontaneous vaginal delivery at term. Participants were randomized into a 1:1 ratio to receive either 0.125 mg methylergometrine per os twice a day or placebo for 10 d. Hemoglobin levels were recorded on the day of delivery and after 10 d. The primary outcome was the variation in hemoglobin levels between the first and the 10th day of treatment. RESULTS: From December 2012 to October 2015, 220 agreed to take part in the study, underwent randomization, and were enrolled and followed-up. Of the randomized women, 110 (50%) were randomized to the methylergometrine group and 110 (50%) to the placebo group. No women were excluded after randomization or lost to follow-up (100%). We found no significant difference in the median variation of hemoglobin levels between the intervention and the placebo group Conclusions: The use of 10 d oral methylergometrine in puerperal women was not associated with any benefit in the variation of hemoglobin levels from delivery to 10 d after delivery. Key Message Methylergometrine in puerperal women was not associated with any benefit

A design technique of reflectarrays with improved frequency performances

A new synthesis technique for wideband contoured beam reflectarray antenna is presented. Constraints on the frequency behaviour of the antenna on a prescribed frequency band are enforced and a phase only synthesis approach is adopted. The performances of the presented technique are shown by a wide numerical analysis. The comparison with a standard single frequency synthesis algorithm and with an approach based on the compensation of the frequency dispersion of the optical path is also performed