Bibliotecas Comunitárias: fatores intervenientes na percepção das gestoras

TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Educação. Curso de Biblioteconomia.Aborda o contexto de duas bibliotecas comunitárias: Barca dos Livros, localizada na Lagoa da Conceição e Biblioteca Livre do [Bairro] Campeche (BILICA), ambas situadas em Florianópolis/SC. Parte do entendimento de que estas unidades de informação tem papel fundamental para a cultura, ensino-aprendizagem, desenvolvimento humano e inclusão social, atenuando em muitas vezes os déficits de formação de leitores que a educação formal não proporciona. Objetiva conhecer a percepção das gestoras sobre fatores intervenientes na criação e manutenção das bibliotecas comunitárias objeto do estudo. Trata-se de uma pesquisa exploratória- descritiva, de acordo com os objetivos apresentados, classificando-se também como pesquisa bibliográfica pela utilização de materiais bibliográficos sobre o tema. Como instrumento de coleta de dados utiliza entrevista estruturada e, como participantes da pesquisa as gestoras de duas bibliotecas comunitárias mais relevantes de Florianópolis, tal escolha se deu por entender que as gestoras detém amplo conhecimento sobre o assunto, devido sua participação desde a criação das bibliotecas até os dias atuais. A entrevista proporcionou conhecer a percepção que possuem em relação aos fatores intervenientes estudados. Aponta a importância do funcionamento e a gestão da biblioteca comunitária, muitos vezes sem recursos financeiros de governos, bem como a importância do trabalho voluntário.Addresses the context of two community libraries: Barca dos Livros, located in Lagoa da Conceição and Biblioteca Livre of [Quarter] Campeche (BILICA), both located in Florianópolis/SC. Part of the understanding that these information units play a key role for culture, teaching and learning, human development and social inclusion, reducing many times the deficits that formal education does not provide. It aims to know the perception of the management of intervening factors in the creation and maintenance of community libraries object of study. It is a descriptive exploratory-research, according to the presented goals, also ranking it as literature for the use of bibliographic material on the subject. As data collection instrument utilizes structured interview and survey participants as the management of two most relevant community libraries of Florianópolis, such a choice was given to understand that the management has extensive knowledge on the subject, because its share since the creation of libraries to the present day. The interview gave know the perception they have regarding the studied influencing factors. It points out the importance of the operation and the management of community library, many times without financial resources of governments, as well as the importance of volunteer work

Treatment of keratinocytes with 4-phenylbutyrate in epidermolysis bullosa: Lessons for therapies in keratin disorders

Missense mutations in keratin 5 and 14 genes cause the severe skin fragility disorder epidermolysis bullosa simplex (EBS) by collapsing of the keratin cytoskeleton into cytoplasmic protein aggregates. Despite intense efforts, no molecular therapies are available, mostly due to the complex phenotype of EBS, comprising cell fragility, diminished adhesion, skin inflammation and itch.Methods: We extensively characterized KRT5 and KRT14 mutant keratinocytes from patients with severe generalized EBS following exposure to the chemical chaperone 4-phenylbutyrate (4- PBA).Findings: 4-PBA diminished keratin aggregates within EBS cells and ameliorated their inflammatory phenotype. Chemoproteomics of 4-PBA-treated and untreated EBS cells revealed reduced IL1β expression- but also showed activation of Wnt/β-catenin and NF-kB pathways. The abundance of extracellular matrix and cytoskeletal proteins was significantly altered, coinciding with diminished keratinocyte adhesion and migration in a 4-PBA dose-dependent manner.Interpretation: Together, our study reveals a complex interplay of benefits and disadvantages that challenge the use of 4-PBA in skin fragility disorders

Special orthopaedic geriatrics (SOG) - a new multiprofessional care model for elderly patients in elective orthopaedic surgery: a study protocol for a prospective randomized controlled trial of a multimodal intervention in frail patients with hip and knee replacement

Background Due to demographic change, the number of older people in Germany and worldwide will continue to rise in the coming decades. As a result, the number of elderly and frail patients undergoing total hip and knee arthroplasty is projected to increase significantly in the coming years. In order to reduce risk of complications and improve postoperative outcome, it can be beneficial to optimally prepare geriatric patients before orthopaedic surgery and to provide perioperative care by a multiprofessional orthogeriatric team. The aim of this comprehensive interventional study is to assess wether multimorbid patients can benefit from the new care model of special orthopaedic geriatrics (SOG) in elective total hip and knee arthroplasty. Methods The SOG study is a registered, monocentric, prospective, randomized controlled trial (RCT) funded by the German Federal Joint Committee (GBA). This parallel group RCT with a total of 310 patients is intended to investigate the specially developed multimodal care model for orthogeriatric patients with total hip and knee arthroplasty (intervention group), which already begins preoperatively, in comparison to the usual orthopaedic care without orthogeriatric co-management (control group). Patients ≥70 years of age with multimorbidity or generally patients ≥80 years of age due to increased vulnerability with indication for elective primary total hip and knee arthroplasty can be included in the study. Exclusion criteria are age < 70 years, previous bony surgery or tumor in the area of the joint to be treated, infection and increased need for care (care level ≥ 4). The primary outcome is mobility measured by the Short Physical Performance Battery (SPPB). Secondary outcomes are morbidity, mortality, postoperative complications, delirium, cognition, mood, frailty, (instrumental) activities of daily living, malnutrition, pain, polypharmacy, and patient reported outcome measures. Tertiary outcomes are length of hospital stay, readmission rate, reoperation rate, transfusion rate, and time to rehabilitation. The study data will be collected preoperative, postoperative day 1 to 7, 4 to 6 weeks and 3 months after surgery. Discussion Studies have shown that orthogeriatric co-management models in the treatment of hip fractures lead to significantly reduced morbidity and mortality rates. However, there are hardly any data available on the elective orthopaedic care of geriatric patients, especially in total hip and knee arthroplasty. In contrast to the care of trauma patients, optimal preoperative intervention is usually possible

Radiological outcome of postoperative sagittal balance on standing radiographs in comparison to intraoperative radiographs in prone position when performing lumbar spinal fusion

Aim of this study is to show the outcome of postoperatively measured lumbar lordosis in upright position in comparison to the intraoperatively estimated lumbar lordosis in prone position, as the lumbar lordosis is one of the most important factors for the clinical outcome after spinal fusion. Eighty-two patients, receiving lumbar fusion were included in this retrospective study. Intraoperative radiographs were scanned. Then radiographs of the whole spine pre- and postoperatively, as well as 1 year after surgery were measured by a spine surgeon and a radiologist. The visible segment lordosis angles were measured and compared (L2-S1, L3-S1, L4-S1, L5-S1). In addition, the pelvic parameters pelvic incidence, pelvic tilt and sacral slope were measured pre- and postoperatively. The intraobserver reliability was almost perfect. The mean lordosis angle L4-S1 was 32.6A degrees A +/- 7.8A degrees intraoperatively and 29A degrees A +/- 10.8A degrees postoperatively. A linear correlation of these two measurements can be seen. In mean, the postoperative lordosis is 4A degrees smaller than intraoperatively. This trend can also be seen in the level L3-S1. In levels L2-S1 and L5-S1 the postoperative values were slightly higher than intraoperatively, but without any significance. Also, 1 year after surgery there were no significant changes in global lumbar lordosis. Measuring lordosis angles intraoperatively resulted in almost the same values as measurements in standing plane radiographs postoperatively, despite prone position. These findings could especially be shown for the level L4-S1. The intraobserver reliability was almost perfect for both, intra- and postoperative measurements. In conclusion, the intraoperative measurement of a lumbar lordosis angle can perfectly predict the postoperative result

Regarding loads after spinal fusion, every level should be seen separately: a musculoskeletal analysis

The number of spinal fusion surgeries is steadily increasing and biomechanical consequences are still in debate. The aim of this study is to provide biomechanical insights into the sagittal balance of the spine and to compare spinal load before and after spinal fusion. The joint reaction forces of 52 patients were analyzed in proximo-distal and antero-posterior direction from the levels T12-L1 to L5-S1 using musculoskeletal simulations. In 104 simulations, pre-surgical forces were equal to post-surgical. The levels L4-L5 and T12-L1, however, showed increased spinal forces compression forces with higher sagittal displacement. Improved restauration of sagittal balance was accompanied by lower spinal load. AP shear stress, interestingly decreased with sagittal imbalance. Imbalanced spines have a risk of increased compression forces at Th12-L1. L4-L5 always has increased spinal loads. These slides can be retrieved under Electronic Supplementary Material. [GRAPHICS]

Imbalances in protein homeostasis caused by mutant desmin

Mutations of the human desmin gene on chromosome 2q35 cause autosomal-dominant and -recessive myopathies and cardiomyopathies. For pathophysiological and therapeutic studies, we generated and characterized R349P desmin knock-in mice, which serve as patient-mimicking disease models for desminopathies. By crossbreeding our desminopathy with p53 knock-out mice, we generated immortalized desminopathy myoblast cell lines. We used these myoblasts in conjunction with skeletal muscle tissue from the desminopathy mice to study the effects of R349P mutant desmin on the ubiquitin-proteasome system, bulk autophagy, chaperone-assisted selective autophagy, and heat shock proteins