Effectiveness of Low Intensity Aquatic Exercise and Floor Exercise in Improving Functional Vital Capacity and Forced Expiratorty Volume among Subjects with COPD: A Comparative study

INTRODUCTION: Despite the growing number of studies reporting therapeutic success in water environments, research involving aquatic exercise among patients with Chronic Obstructive Pulmonary Disease (COPD) is scarce. This study evaluates the impact of low-intensity aquatic exercise and floor exercises on COPD. PURPOSE OF THE STUDY: The purpose of the study is to compare the effectiveness of low intensity aquatic exercise in improving functional capacity and forced expiratory volume among subjects with COPD. METHODOLOGY: 30 subjects were selected based on the inclusion and exclusion criteria and were divided into two groups, Group A (15) and Group B (15). Group A received low intensity Floor exercise and Group B received low intensity Aquatic exercise and the Functional capacity and Forced Expiratory volume were measured using the 6 minute walk test, spirometer. RESULTS: Both groups showed significant improvement in vital capacity and forced expiratory volume after treatment program. Aquatic group showed clinically and statistically significant improvement in vital capacity and expiratory forced volume when compared to the floor group. CONCLUSION: The study concluded that the subjects in the Aquatic exercise group showed statistically significant improvement (i.e) the subjects in (Group B) showed increase in functional capacity and forced expiratory volume when compared to the subjects in floor group (Group A)

IN VITRO ANTIPLASMODIAL ACTIVITY OF NATIVE INDIAN SEAWEED SARGASSUM SP.

ABSTRACTObjectives: To investigate the antiplasmodial activity of three different solvent extracts of Sargassum tenerrimum against Plasmodium falciparum.Methods: The seaweed species of S. tenerrimum were collected from Rameshwaram, Southeast coast of India. The collected samples were dried andextracted with three different polaritic (hexane, acetone, and ethylacetate) solvents and tested against P. falciparum parasite strain.Results: Acetone extract exhibited better activity than the other two extracts. The inhibitory concentration values of acetone S. tenerrimum werefound to be 27.82 and 18.14 µg/ml at 24-48 hrs, respectively. S. tenerrimum crude extracts were subjected for the phytochemical analysis, and itshowed the presence of steroids, alkaloids, flavonoids, tannins, glycosides, amino acids, and phenol compounds. The gas chromatography-massspectroscopy result reveals that the presence of 10 major and minor compounds in the S. tenerrimum extract. In that, cyclotrisiloxane hexamethylcompounds might be responsible for the effective parasite suppression.50Conclusion: It can be concluded from the present study that the acetone extract of S. tenerrimum has strong antiplasmodial activity. Furthermore, thestudy has been extended to the isolation of the possible active compounds that is responsible for the antiplasmodial properties.Keywords: Antiplasmodial assay, Different polaritic solvents, Plasmodium falciparum, Sargassum tenerrimum

Effect of ultrasonication and enzyme activity on dye uptake of cationised cotton fabric

To eliminate the usage of salt, salt-free reactive dyeing using CHPTAC (3-Chloro-2-hydroxypropyl trimethylammonium chloride) has been proposed. Studies have shown promising results, such as better dye shade attainment and less effluent load compared to conventional methods. In this work, to improve the effective utilisation of CHPTAC, the cotton fabric has been treated with cellulase enzyme and the application of CHPTAC is carried out using the ultrasonication technique. The samples are then characterised for colour parameters and it is found that the enzymatic treatment and ultrasonication lead to improve the dye uptake, as the interaction of CHPTAC with the fabric becomes better.

Preparation and Characterization of Silver Nanoparticle/Aloe Vera Incorporated PCL/PEO matrix for wound dressing application

35-44Polymeric wound dressing materials have remarkable mechanical, structural, and biocompatible behavior. In this work, a polymer matrix of Polycaprolactone (PCL)/Polyethylene Oxide (PEO) incorporated with Aloe Vera (AV) extract and silver nanoparticles were prepared for wound dressing application. Initially, the phytochemicals from AV were extracted by Soxhlet apparatus, and then the aloe extract was used as a reducing agent to synthesize silver nanoparticles (Ag NP). Ag NP's formation was confirmed by the presence of a characteristic UV absorbance peak at 420 nm. Ag NP's average diameter and shape were found to be between 10-50 nm and spherical, respectively. AV extract and Ag NP were incorporated into PCL/PEO polymer solution to prepare the polymer matrix by solution casting method. Box-Behnken design (BBD) was used to study the effect of Ag NP concentration, AV extract percentage, and PEO weight percentage concerning PCL on wound dressing application. Water Vapor Transmission Rate (WVTR) and swelling properties of all the sample were tested and found that the PEO and AV extract plays a major role in both swelling and WVTR irrespective of Ag NP concentration. The antimicrobial property of synthesized Ag NP was studied against gram-negative bacteria Escherichia coli with control samples (PCL and PCL/PEO), Ag NP with 150 mg concentration showed a higher zone of inhibition than the other concentrations. Thus, the prepared PCL/PEO polymer matrix incorporated with AV extract and Ag NP can be used as an effective wound dressing material

Preparation and Characterization of Silver Nanoparticle/Aloe Vera Incorporated PCL/PEO matrix for wound dressing application

Polymeric wound dressing materials have remarkable mechanical, structural, and biocompatible behavior. In this work, a polymer matrix of Polycaprolactone (PCL)/Polyethylene Oxide (PEO) incorporated with Aloe Vera (AV) extract and silver nanoparticles were prepared for wound dressing application. Initially, the phytochemicals from AV were extracted by Soxhlet apparatus, and then the aloe extract was used as a reducing agent to synthesize silver nanoparticles (Ag NP). Ag NP's formation was confirmed by the presence of a characteristic UV absorbance peak at 420 nm. Ag NP's average diameter and shape were found to be between 10-50 nm and spherical, respectively. AV extract and Ag NP were incorporated into PCL/PEO polymer solution to prepare the polymer matrix by solution casting method. Box-Behnken design (BBD) was used to study the effect of Ag NP concentration, AV extract percentage, and PEO weight percentage concerning PCL on wound dressing application. Water Vapor Transmission Rate (WVTR) and swelling properties of all the sample were tested and found that the PEO and AV extract plays a major role in both swelling and WVTR irrespective of Ag NP concentration. The antimicrobial property of synthesized Ag NP was studied against gram-negative bacteria Escherichia coli with control samples (PCL and PCL/PEO), Ag NP with 150 mg concentration showed a higher zone of inhibition than the other concentrations. Thus, the prepared PCL/PEO polymer matrix incorporated with AV extract and Ag NP can be used as an effective wound dressing material

PROGERIA IN SIBLINGS: A RARE CASE REPORT

Progeria, also known as Hutchinson-Gilford syndrome, is an extremely rare, severe genetic condition wherein symptoms resembling aspects of aging are manifested at an early age. It is an autosomal dominant disorder. It is not seen in siblings of affected children although there are very few case reports of progeria affecting more than one child in a family. Here we are presenting two siblings, a 14-year-old male and a 13-year-old female with features of progeria, suggesting a possible autosomal recessive inheritance

Effect of ultrasonication and enzyme activity on dye uptake of cationised cotton fabric

35-40To eliminate the usage of salt, salt-free reactive dyeing using CHPTAC (3-Chloro-2-hydroxypropyl trimethylammonium chloride) has been proposed. Studies have shown promising results, such as better dye shade attainment and less effluent load compared to conventional methods. In this work, to improve the effective utilisation of CHPTAC, the cotton fabric has been treated with cellulase enzyme and the application of CHPTAC is carried out using the ultrasonication technique. The samples are then characterised for colour parameters and it is found that the enzymatic treatment and ultrasonication lead to improve the dye uptake, as the interaction of CHPTAC with the fabric becomes better

Anti-cancerous Activities of Anthocyanins of Banana cv. Nendran (Musa sp.) Flower Bracts against Human Colon and Cervical Cancer Cell Lines.

Anti-cancerous properties of anthocyanins extracted from banana (cv. Nendran) bract has been discussed.A comparative study on the anticancer effects of anthocyanins derived from banana cv. Nendran flower bracts against human colon (HT-29) and cervical cancer (HeLa) cells were investigated. In vitro assays by MTT, AO/EtBr and MMP revealed that anthocyanins extract inhibited the growth of both HT-29 and HeLa cells. The percentage of cell viability decreased linearly with the increment of anthocyanins. The IC50 values for anthocyanins were 41.18 µg/ml for colon cancer cells and 46.50 µg/ml for cervical cancer cells by MTT assay. The MMP assay indicated IC50 values of 71.18 and 106.5 µg/ml respectively for HT-29 cells and HeLa cells. The study demonstrates that anthocyanins of banana flower bracts are potential anti-cancerous compounds.ICA