1 research outputs found
Dusty Air Pollution is Associated with an Increased Risk of Allergic Diseases in Southwestern Part of Iran
Concerns have been raised about the adverse impact of dusty air pollution (DAP) on
human health. The aim of this study was to find the association between dusty air pollution
based on air quality index (AQI) and the risk of allergic diseases in southwestern provinces
of Iran, with assessing cytokine profiles and lymphocyte immunophenotypes.
In this case control study 148 individuals participated. The sampling was done in
hazardous condition (AQI >300) as the case and clean air (AQI <50) as the control. We
measured cytokine production by using ELISA method and phenotypes of T-lymphocytes
(CD4+ and CD8+), CD19+ B-lymphocytes, CD25+, CD4+ CD25+ cells by FACSort flow
cytometer.
The mean serum level of IL-4 (33.4±2.9 vs 0.85± 0.65 pg/dl) and IL-13 (15.1±4.4 vs.
0.12±0.7 pg/dl) in the subjects exposed to ambient DAP was increased significantly
compared to the individuals in the clean air condition. Also, CD19+ B-lymphocytes (12.6±
4.9 vs 8.9±3.2%) and CD4+ CD25+ cell count (13.6± 4.6 vs 7.7± 3.8%) in peripheral blood
were increased significantly in subjects exposed to ambient DAP compared with the
controls.
The result of our study suggested that ambient DAP affected immune system in a way
that might lead to allergic diseases in the population