124 research outputs found
Transplante cardíaco no Instituto Dante Pazzanese de Cardiologia: análise da sobrevida
The presence of depressive symptoms and cognitive performance among older individuals with and without self-reported chronic diseases
ABSTRACT. Dementias secondary to cardiovascular diseases are the second cause of neurogenerative diseases. These conditions can be prevented by controlling risk factors, and it is necessary to observe the relationship between chronic diseases. Objective: to know the influence of chronic non-communicable diseases on cognition and depressive symptoms in the elderly, amid the COVID-19 pandemic. Methods: 578 older adults were evaluated using a sociodemographic questionnaire, the Brazilian Telephone version of the Mini Mental State Examination (Braztel-MMSE), the Geriatric Depression Scale (GDS-15) and an open questionnaire related to NCDs. Results: the association of Non-Communicable Diseases (NCD) with age, depressive symptoms and schooling was confirmed. Conclusion: no association with cognitive decline was evident due to the relationship of high schooling of participants and control of NCDs
Design, Synthesis and Characterization of N-oxide-containing Heterocycles with In vivo Sterilizing Antitubercular Activity
Tuberculosis, caused by the Mycobacterium tuberculosis (Mtb), is the infectious disease
responsible for the highest number of deaths worldwide. Herein, 22 new N-oxide-
containing compounds were synthesized followed by in vitro and in vivo evaluation of
their antitubercular potential against Mtb. Compound 8 was found to be the most
promising compound, with MIC90 values of 1.10 and 6.62 μM against active and non-
replicating Mtb, respectively. Additionally, we carried out in vivo experiments to confirm
the safety and efficacy of compound 8; the compound was found to be orally bioavailable
and highly effective leading to the reduction of the number of Mtb to undetected levels in
a mouse model of infection. Microarray-based initial studies on the mechanism of action
suggest that compound 8 blocks the process of translation. Altogether, these results
indicated benzofuroxan derivative 8 to be a promising lead compound for the
development of a novel chemical class of antitubercular drugs
Educomunicação, Transformação Social e Desenvolvimento Sustentável
Esta publicação apresenta os principais trabalhos dos GTs do II Congresso Internacional de Comunicação e Educação nos temas Transformação social, com os artigos que abordam principalmente Educomunicação e/ou Mídia-Educação, no contexto de políticas de diversidade, inclusão e equidade; e, em Desenvolvimento Sustentável os artigos que abordam os avanços da relação comunicação/educação no contexto da educação ambiental e desenvolvimento sustentável
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