Composição para inativação viral, processo de inativação viral, vacina e processo de produção de vacina

Em 19/05/2016: Anuidade de pedido de patente de invenção no prazo ordinário.DepositadaA presente invenção refere-se a uma composição para inativação viral que compreende solução aquosa de DEPC (dietilpirocarbonato); a referida composição é útil para a inativação do vírus VSV em um processo de inativação viral, que por sua vez é útil para a preparação de vacinas

Pocket Rehab - mHealth-based rehabilitation program for patients with cardiovascular disease as a prevention and treatment strategy for COVID-19 victims : an international multicentric collaborative study

Pacientes com doença cardiovascular e fatores de risco para doença cardiovascular (DCV) têm sido afetados com mais frequência e mais gravemente pelo novo coronavírus. Isso agravou o cenário anterior de subutilização dos programas de reabilitação cardiovascular (RCV) antes da pandemia, exigindo alternativas otimizadas de RCV, como por exemplo aquelas baseadas em aplicativos móveis (mHeath), não apenas por gerar benefícios bem estabelecidos, mas agora também para manter esses pacientes clinicamente estáveis, diminuindo a chance de eventos cardiovasculares e risco de contaminação naqueles não infectados pelo vírus, bem como tratando dos sobreviventes da COVID-19, tendo em vista as disfunções adicionais que tem sido descritas nos sistemas respiratório, cardiovascular e muscular. Serão realizados dois estudos: o estudo 1, qualitativo, de concordância e reprodutibilidade. Criação aplicativo baseado em tecnologia móvel (mHealth), para dar suporte a um programa otimizado (capaz de avaliar após COVID-19) de reabilitação cardiovascular (RCV) em ambiente domiciliar, desenvolvido pela Universidade do Luxemburgo (Centro 4), integrando instrumentos reconhecidos internacionalmente, como o EXPERT Tool, Hasselt University (Centro 3) e PACERProject, University of Miami (Centro 2). O aplicativo será testado e avaliado por profissionais de saúde nos dois centros colaboradores do estudo (Centro 2 e Centro 3) e na instituição executora - Universidade de Brasília (Centro 1)

Relationship of Lung Function and Inspiratory Strength with Exercise Capacity and Prognosis in Heart Failure

Spirometry is underused in heart failure (HF) and the extent to which each defect associates with exercise capacity and prognosis is unclear. To determine the distinct relationship of continuous %predicted FVC (ppFVC) and FEV1/FVC with: 1) maximal inspiratory pressure (MIP), left ventricular ejection fraction (LVEF), exercise performance; and 2) prognosis for the composite of cardiovascular death, heart transplantation or left ventricular assist device implant. A cohort of 111 HF participants (AHA stages C/D) without diagnosed pneumopathy, spirometry, manovacuometry and maximum cardiopulmonary test. The association magnitudes were verified by linear and Cox (HR; 95% CI) regressions, age/sex adjusted. A p<0.05 was considered significant. Age was 57±12 years, 60% men, 64% in NYHA III. Every 10%-point increase in FEV1/FVC [β 7% (95% CI: 3-10)] and ppFVC [4% (2-6)] associated with ventilatory reserve (VRes), however only ppFVC associated with MIP [3.8 cmH2O (0.3-7.3)], LVEF [2.1% (0.5-3.8)] and VO2peak [0.5 mL/kg/min (0.1-1.0)], accounting for age/sex. In 2.2 years (mean), 22 events occurred, and neither FEV1/FVC (HR 1.44; 95% CI: 0.97-2.13) nor ppFVC (HR 1.13; 0.89-1.43) was significantly associated with the outcome. Only in the LVEF ≤50% subgroup (n=87, 20 events), FEV1/FVC (HR 1.50; 1.01-2.23), but not ppFVC, was associated with greater risk. In chronic HF, reduced ppFVC associated with lower MIP, LVEF, VRes and VO2peak, but no distinct poorer prognosis over 2.2 years of follow-up. Distinctively, FEV1/FVC was associated only with VRes, and, in participants with LVEF ≤50%, FEV1/FVC reduction proportionally worsened prognosis. Therefore, FEV1/FVC and ppFVC add supplementary information regarding HF phenotyping

Resistance exercise enhances oxygen uptake without worsening cardiac function in patients with systolic heart failure: a systematic review and meta-analysis

Recent literature suggests that resistance training (RT) improves peak oxygen uptake ([Formula: see text] peak), similarly to aerobic exercise (AE) in patients with heart failure (HF), but its effect on cardiac remodeling is controversial. Thus, we examined the effects of RT and AE on [Formula: see text] peak and cardiac remodeling in patients with heart failure (HF) via a systematic review and meta-analysis. MEDLINE, EMBASE, Cochrane Library and CINAHL, AMEDEO and PEDro databases search were extracted study characteristics, exercise type, and ventricular outcomes. The main outcomes were [Formula: see text] peak (ml kg  min ), LVEF (%) and LVEDV (mL). Fifty-nine RCTs were included. RT produced a greater increase in [Formula: see text] peak (3.57 ml kg  min , P < 0.00001, I  = 0%) compared to AE (2.63 ml kg  min , P < 0.00001, I  = 58%) while combined RT and AE produced a 2.48 ml kg  min increase in [Formula: see text]; I  = 69%) compared to control group. Comparison among the three forms of exercise revealed similar effects on [Formula: see text] peak (P = 0.84 and 1.00, respectively; I  = 0%). AE was associated with a greater gain in LVEF (3.15%; P < 0.00001, I  = 17%) compared to RT alone or combined exercise which produced similar gains compared to control groups. Subgroup analysis revealed that AE reduced LVEDV (- 10.21 ml; P = 0.007, I  = 0%), while RT and combined RT and AE had no effect on LVEDV compared with control participants. RT results in a greater gain in [Formula: see text] peak, and induces no deleterious effects on cardiac function in HF patients