4,482 research outputs found
Real-time tracking of delayed-onset cellular apoptosis induced by intracellular magnetic hyperthermia
AIM: To assess cell death pathways in response to magnetic hyperthermia. MATERIALS & METHODS: Human melanoma cells were loaded with citric acid-coated iron-oxide nanoparticles, and subjected to a time-varying magnetic field. Pathways were monitored in vitro in suspensions and in situ in monolayers using fluorophores to report on early-stage apoptosis and late-stage apoptosis and/or necrosis. RESULTS: Delayed-onset effects were observed, with a rate and extent proportional to the thermal-load-per-cell. At moderate loads, membranal internal-to-external lipid exchange preceded rupture and death by a few hours (the timeline varying cell-to-cell), without any measurable change in the local environment temperature. CONCLUSION: Our observations support the proposition that intracellular heating may be a viable, controllable and nonaggressive in vivo treatment for human pathological conditions
Nickel-doped ceria nanoparticles : the effect of annealing on room temperature ferromagnetism
Nickel-doped cerium dioxide nanoparticles exhibit room temperature ferromagnetism due to high oxygen mobility within the doped CeO2 lattice. CeO2 is an excellent doping matrix as it can lose oxygen whilst retaining its structure. This leads to increased oxygen mobility within the fluorite CeO2 lattice, leading to the formation of Ce3+ and Ce4+ species and hence doped ceria shows a high propensity for numerous catalytic processes. Magnetic ceria are important in several applications from magnetic data storage devices to magnetically recoverable catalysts. We investigate the effect doping nickel into a CeO2 lattice has on the room temperature ferromagnetism in monodisperse cerium dioxide nanoparticles synthesised by the thermal decomposition of cerium(III) and nickel(II) oleate metal organic precursors before and after annealing. The composition of nanoparticles pre- and post-anneal were analysed using: TEM (transmission electron microscopy), XPS (X-ray photoelectron spectroscopy), EDS (energy-dispersive X-ray spectroscopy) and XRD (X-ray diffraction). Optical and magnetic properties were also studied using UV/Visible spectroscopy and SQUID (superconducting interference device) magnetometry respectively
Spin Stiffness of Stacked Triangular Antiferromagnets
We study the spin stiffness of stacked triangular antiferromagnets using both
heat bath and broad histogram Monte Carlo methods. Our results are consistent
with a continuous transition belonging to the chiral universality class first
proposed by Kawamura.Comment: 5 pages, 7 figure
Evidence for the droplet/scaling picture of spin glasses
We have studied the Parisi overlap distribution for the three dimensional
Ising spin glass in the Migdal-Kadanoff approximation. For temperatures T
around 0.7Tc and system sizes upto L=32, we found a P(q) as expected for the
full Parisi replica symmetry breaking, just as was also observed in recent
Monte Carlo simulations on a cubic lattice. However, for lower temperatures our
data agree with predictions from the droplet or scaling picture. The failure to
see droplet model behaviour in Monte Carlo simulations is due to the fact that
all existing simulations have been done at temperatures too close to the
transition temperature so that sytem sizes larger than the correlation length
have not been achieved.Comment: 4 pages, 6 figure
Heisenberg frustrated magnets: a nonperturbative approach
Frustrated magnets are a notorious example where the usual perturbative
methods are in conflict. Using a nonperturbative Wilson-like approach, we get a
coherent picture of the physics of Heisenberg frustrated magnets everywhere
between and . We recover all known perturbative results in a single
framework and find the transition to be weakly first order in . We compute
effective exponents in good agreement with numerical and experimental data.Comment: 5 pages, Revtex, technical details available at
http://www.lpthe.jussieu.fr/~tissie
Inhibition of insulin secretion from rat islets of Langerhans by interleukin-6. An effect distinct from that of interleukin-1
From one cell to the whole froth: a dynamical map
We investigate two and three-dimensional shell-structured-inflatable froths,
which can be constructed by a recursion procedure adding successive layers of
cells around a germ cell. We prove that any froth can be reduced into a system
of concentric shells. There is only a restricted set of local configurations
for which the recursive inflation transformation is not applicable. These
configurations are inclusions between successive layers and can be treated as
vertices and edges decorations of a shell-structure-inflatable skeleton. The
recursion procedure is described by a logistic map, which provides a natural
classification into Euclidean, hyperbolic and elliptic froths. Froths tiling
manifolds with different curvature can be classified simply by distinguishing
between those with a bounded or unbounded number of elements per shell, without
any a-priori knowledge on their curvature. A new result, associated with
maximal orientational entropy, is obtained on topological properties of natural
cellular systems. The topological characteristics of all experimentally known
tetrahedrally close-packed structures are retrieved.Comment: 20 Pages Tex, 11 Postscript figures, 1 Postscript tabl
The nature of the different zero-temperature phases in discrete two-dimensional spin glasses: Entropy, universality, chaos and cascades in the renormalization group flow
The properties of discrete two-dimensional spin glasses depend strongly on
the way the zero-temperature limit is taken. We discuss this phenomenon in the
context of the Migdal-Kadanoff renormalization group. We see, in particular,
how these properties are connected with the presence of a cascade of fixed
points in the renormalization group flow. Of particular interest are two
unstable fixed points that correspond to two different spin-glass phases at
zero temperature. We discuss how these phenomena are related with the presence
of entropy fluctuations and temperature chaos, and universality in this model.Comment: 14 pages, 5 figures, 2 table
The influence of critical behavior on the spin glass phase
We have argued in recent papers that Monte Carlo results for the equilibrium
properties of the Edwards-Anderson spin glass in three dimensions, which had
been interpreted earlier as providing evidence for replica symmetry breaking,
can be explained quite simply within the droplet model once finite size effects
and proximity to the critical point are taken into account. In this paper, we
show that similar considerations are sufficient to explain the Monte Carlo data
in four dimensions. In particular, we study the Parisi overlap and the link
overlap for the four-dimensional Ising spin glass in the Migdal-Kadanoff
approximation. Similar to what is seen in three dimensions, we find that
temperatures well below those studied in Monte Carlo simulations have to be
reached before the droplet model predictions become apparent. We also show that
the double-peak structure of the link overlap distribution function is related
to the difference between domain-wall excitations that cross the entire system
and droplet excitations that are confined to a smaller region.Comment: 8 pages, 8 figure
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