5,994 research outputs found
Formation of magnetic minerals at hydrocarbon-generation conditions
In this paper, we report the pyrolysis and formation of magnetic minerals in three source rock samples from the Wessex Basin in Dorset, southern England. The experimental conditions in the laboratory recreated the catagenesis environment of oil source rocks. Magnetic analysis of both the heated and the unheated samples at room temperature and at very low-temperatures (5 K), coupled with transmission electron-microscopy imaging and X-ray analysis, revealed the formation of nanometre-sized (<10 nm), magnetic particles that varied across the rock samples analysed, but more importantly across the pyrolysis temperature range. Magnetic measurements demonstrated the formation of these magnetic minerals peaked at 250 °C for all rock samples and then decreased at 300 °C before rising again at 320 °C. The newly formed magnetic minerals are suggested to be primarily pyrrhotite, though magnetite and greigite are also thought to be present. The sizes of the magnetic minerals formed suggest a propensity to migrate together with oil potentially explaining the magnetic anomalies observed above and within oil fields
RASS-SDSS Galaxy Cluster Survey. VI. The dependence of the cluster SFR on the cluster global properties
Using a subsample of 79 nearby clusters from the RASS-SDSS galaxy cluster
catalogue of Popesso et al. (2005a), we perform a regression analysis between
the cluster integrated star formation rate (Sigma_SFR) the cluster total
stellar mass (M_star), the fractions of star forming (f_SF) and blue (f_b)
galaxies and other cluster global properties, namely its richness (N_gal, i.e.
the total number of cluster members within the cluster virial radius), velocity
dispersion (sigma_v), virial mass (M_200), and X-ray luminosity (L_X). All
cluster global quantities are corrected for projection effects before the
analysis. Galaxy SFRs and stellar masses are taken from the catalog of
Brinchmann et al. (2004), which is based on SDSS spectra. We only consider
galaxies with M_r <= -20.25 in our analysis, and exclude AGNs. We find that
both Sigma_SFR and M_star are correlated with all the cluster global
quantities. A partial correlation analysis show that all the correlations are
induced by the fundamental one between Sigma_SFR and N_gal, hence there is no
evidence that the cluster properties affect the mean SFR or M_star per galaxy.
The relations between Sigma_SFR and M_star, on one side, and both N_gal and
M_200, on the other side, are linear, i.e. we see no evidence that different
clusters have different SFR or different M_star per galaxy and per unit mass.
The fraction f_SF does not depend on any cluster property considered, while f_b
does depend on L_X. We note that a significant fraction of star-forming cluster
galaxies are red (~25% of the whole cluster galaxy population). We conclude
that the global cluster properties are unable to affect the SF properties of
cluster galaxies, but the presence of the X-ray luminous intra-cluster medium
can affect their colors, perhaps through the ram-pressure stripping mechanism.Comment: 14 pages, 12 figures, accepted for publication on A&A; corrected
coefficient in Tab.
Hyperthermia treatment of tumors by mesenchymal stem cell-delivered superparamagnetic iron oxide nanoparticles.
Magnetic hyperthermia - a potential cancer treatment in which superparamagnetic iron oxide nanoparticles (SPIONs) are made to resonantly respond to an alternating magnetic field (AMF) and thereby produce heat - is of significant current interest. We have previously shown that mesenchymal stem cells (MSCs) can be labeled with SPIONs with no effect on cell proliferation or survival and that within an hour of systemic administration, they migrate to and integrate into tumors in vivo. Here, we report on some longer term (up to 3 weeks) post-integration characteristics of magnetically labeled human MSCs in an immunocompromized mouse model. We initially assessed how the size and coating of SPIONs dictated the loading capacity and cellular heating of MSCs. Ferucarbotran(®) was the best of those tested, having the best like-for-like heating capability and being the only one to retain that capability after cell internalization. A mouse model was created by subcutaneous flank injection of a combination of 0.5 million Ferucarbotran-loaded MSCs and 1.0 million OVCAR-3 ovarian tumor cells. After 2 weeks, the tumors reached ~100 µL in volume and then entered a rapid growth phase over the third week to reach ~300 µL. In the control mice that received no AMF treatment, magnetic resonance imaging (MRI) data showed that the labeled MSCs were both incorporated into and retained within the tumors over the entire 3-week period. In the AMF-treated mice, heat increases of ~4°C were observed during the first application, after which MRI indicated a loss of negative contrast, suggesting that the MSCs had died and been cleared from the tumor. This post-AMF removal of cells was confirmed by histological examination and also by a reduced level of subsequent magnetic heating effect. Despite this evidence for an AMF-elicited response in the SPION-loaded MSCs, and in contrast to previous reports on tumor remission in immunocompetent mouse models, in this case, no significant differences were measured regarding the overall tumor size or growth characteristics. We discuss the implications of these results on the clinical delivery of hyperthermia therapy to tumors and on the possibility that a preferred therapeutic route may involve AMF as an adjuvant to an autologous immune response
Micromagnetic simulations of interacting dipoles on a fcc lattice: Application to nanoparticle assemblies
Micromagnetic simulations are used to examine the effects of cubic and axial
anisotropy, magnetostatic interactions and temperature on M-H loops for a
collection of magnetic dipoles on fcc and sc lattices. We employ a simple model
of interacting dipoles that represent single-domain particles in an attempt to
explain recent experimental data on ordered arrays of magnetoferritin
nanoparticles that demonstrate the crucial role of interactions between
particles in a fcc lattice. Significant agreement between the simulation and
experimental results is achieved, and the impact of intra-particle degrees of
freedom and surface effects on thermal fluctuations are investigated.Comment: 10 pages, 9 figure
214 Open-label study: a comparison of breathing modes for adaptive aerosol delivery in children with cystic fibrosis
Damage spreading in two dimensional geometrically frustrated lattices: the triangular and kagome anistropic Heisenberg model
The technique of damage spreading is used to study the phase diagram of the
easy axis anisotropic Heisenberg antiferromagnet on two geometrically
frustrated lattices. The triangular and kagome systems are built up from
triangular units that either share edges or corners respectively. The
triangular lattice undergoes two sequential Kosterlitz-Thouless transitions
while the kagome lattice undergoes a glassy transition. In both cases, the
phase boundaries obtained using damage spreading are in good agreement with
those obtained from equilibrium Monte Carlo simulations.Comment: 7 pages, 4 figure
Superparamagnetic iron oxide nanoparticles regulate smooth muscle cell phenotype
Superparamagnetic iron oxide nanoparticles are used for an increasing range of biomedical applications, from imaging to mechanical actuation of cells and tissue. The aim of this study was to investigate the loading of smooth muscle cells with superparamagnetic iron oxide nanoparticles and to explore what effect this has on the phenotype of the cells. Adherent human smooth muscle cells were loaded with ∼17 pg of unconjugated, negatively charged, 50 nm superparamagnetic iron oxide nanoparticles (SPION). Clusters of the internalized SPION particles were held in discrete cytoplasmic vesicles. Internalized SPION did not cause any change in cell morphology, proliferation, metabolic activity, or staining pattern of actin and calponin, two of the muscle contractile proteins involved in force generation. However, internalized SPION inhibited the increased gene expression of actin and calponin normally observed when cells are incubated under differentiation conditions. The observed change in the control of gene expression of muscle contractile apparatus by SPION has not previously been described. This finding could offer novel approaches for regulating the phenotype of smooth muscle cells and warrants further investigation. This article is protected by copyright. All rights reserved
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