Bitter orange (Citrus aurantium L.) intake before submaximal aerobic exercise is safe for cardiovascular and autonomic systems in healthy males: A randomized trial

Background: There are still no studies of the cardiovascular safety of the isolated use of Citrus aurantium in aerobic submaximal exercise. Objective: To evaluate the effect of C. aurantium supplementation on the recovery of cardiorespiratory and autonomic parameters following a session of submaximal aerobic exercise. Methods: Twelve healthy male adults achieved a crossover, randomized, double-blind, and placebo-controlled trial. C. aurantium (600 mg, p-synephrine at 30% amount [180 mg]) or placebo (600 mg of starch) were ingested 90 min before evaluation in randomized days. We evaluated systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), mean arterial pressure (MAP), heart rate (HR) and, HR variability indexes at Rest and during 60 min of recovery from exercise. Results: Citrus aurantium ingestion accelerated the reduction in SBP after exercise, anticipated the return of vagal modulation of the heart after exercise via the HF (ms2), pNN50 (%), and 2 UV% indices. Moreover, rushed the output of sympathetic modulation after exercise via the 0V% index. No unfavorable cardiovascular effects were achieved for HR, DBP, PP, and MAP parameters. Conclusions: Citrus aurantium was shown to be safe for the cardiovascular and autonomic systems alongside submaximal aerobic exercise in healthy males

Nutrição na oncologia infantil: Tratamento nos principais cânceres / Nutrition in child oncology: Treatment in main cancers

A nutrição infantil é imprescindível no tratamento das enfermidades, pois essas crianças apresentam diversas complicações, dependendo do estágio em que a doença se encontra principalmente a desnutrição, podendo acometer seriamente o paciente, tornando o nutricionista, um profissional obrigatório. O objetivo do estudo foi avaliar as terapias nutricionais em pacientes oncológicos infantis. Trata-se de uma revisão integrativa delineando as buscas nas bases de dados Scielo e BIREME, a busca foi realizada no mês de Outubro de 2018. Os critérios de inclusão foram: estar disponível na integra e estudos em português. O câncer nessa faixa etária estudada precisa de vários cuidados com o acompanhamento de uma equipe multidisciplinar, na temática abordada o nutricionista tem diversas funções no tratamento da doença e de acordo com estágio apresentado, a recuperação do sistema imunológico e o cumprimento das necessidades protéicas e energéticas adequadas conforme o quadro do paciente. Tratando-se de uma doença ocorrência constante em idades delicadas, a alimentação é um fator considerável em diversas doenças, precisando de acompanhamento nutriciona

Does bariatric surgery improve cardiac autonomic modulation assessed by heart rate variability? A systematic review

Objectives. Our study aimed to explore the influence of Bariatric Surgery (BS) on heart rate (HR) variability (HRV) through a systematic review. Data Sources. Manuscripts were selected based on electronic searches of MEDLINE, EMBASE and CINAHL databases from the inception of each database up to year 2020 and followed the PRISMA protocol. Searching of these studies was systematized using the PICOS strategy. Eligibility Criteria for Selecting Studies. We selected randomized and non-randomized controlled trials and cohorts’ prospective studies that reported the influence of BS on HRV. We assessed the quality rating using the Black and Downs questionnaire. Results. Following the screening and eligibility stages, 14 studies were included in the review. All studies agreed that BS promotes an increase in parasympathetic HR control and HRV and, a decrease in HR. Yet, the literature does not provide evidence that this outcome was directly caused by the surgical procedure. There is limited evidence to support that patients with type 2 Diabetes Mellitus (TDM2) have greater improvement in HRV as an interim measure, to individuals without. The decrease in insulin resistance was correlated with the increase in HRV in some studies, but, other studies are unsupportive of this outcome. Improvements in two metabolic parameters (e.g., Leptin, NT-proBNP) were connected with a superior increase in HRV

Negligible effects of nutraceuticals from beetroot extract on cardiovascular and autonomic recovery response following submaximal aerobic exercise in physically active healthy males : a randomized trial

Background: There is little evidence that nutraceuticals from beetroot extract are beneficial with regards to recovery of the cardiovascular parameters and the autonomic nervous system (ANS) after submaximal aerobic exercise, though this formulation is employed widely for this purpose. Objective: To study the effects of beetroot extract supplementation on the recovery of cardiorespiratory and autonomic parameters after a session of submaximal aerobic exercise. Methods: Sixteen healthy male adults commenced a cross-over, randomized, double-blind and placebo-controlled trial. Beetroot extract (600 mg) or placebo (600 mg) were ingested 120 min prior to evaluation on randomized days. We assessed systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), mean arterial pressure (MAP), heart rate (HR) and HR variability (HRV) indexes at Rest and during 60 min of recovery from submaximal aerobic exercise. Results: Beetroot extract ingestion slightly accelerated HR, SBP, DBP and MAP reduction following exercise associated to the placebo protocol (vs. rest). Yet no group effect (p = 0.99) was identified between the beetroot and placebo protocols on HR mean, in addition to interaction (group vs. time) (p = 0.60). No group effect was attained between the SBP (p = 0.90), DBP (p = 0.88), MAP (p = 0.73) and PP (p = 0.99) protocols and no significant differences (group vs. time) were observed between the values of SBP (p = 0.75), DBP (p = 0.79), MAP (p = 0.93) and PP (p = 0.63) between placebo and beetroot protocols. Similarly, the reoccurrence of cardiac vagal modulation after exercise via the HF (ms2) was enhanced, but not with regards to the RMSSD index. No group effect (p = 0.99) was identified for the HF (p = 0.90) and RMSSD (p = 0.67) indices. Likewise, we observed no significant differences (group vs. time) amongst the values of HF (p = 0.69) and RMSSD (p = 0.95) between the placebo and beetroot protocols. Conclusion: Whilst beetroot extract might assist the recovery of the cardiovascular and autonomic systems following submaximal aerobic exercise in healthy males, these results seem insignificant owing to minor differences between interventions and are weak clinically