MOESM1 of Design and implementation of a custom next generation sequencing panel for selected vitamin D associated genes

Additional file 1: Table S1. Belfast cohort NODAT association results from Ion S5™ XL and Ion PGM™ sequencing data (Inf= infinity). Table S2. Association of NODAT phenotype in Birmingham cohort (Inf=infinity). Table S3. Birmingham association results from Ion PGM™ sequencing data

Relationship between proteinuria (early morning “spot” albumin:creatinine ration; UACR) and percentage glomerulosclerosis in patients with IFTA on indication biopsy proximate to graft failure (n = 25).

<p>Relationship between proteinuria (early morning “spot” albumin:creatinine ration; UACR) and percentage glomerulosclerosis in patients with IFTA on indication biopsy proximate to graft failure (n = 25).</p

Characteristics of patients displaying ABMR on indication biopsy.

<p>Characteristics of patients displaying ABMR on indication biopsy.</p

Causes of graft failure by period following transplantation.

<p>Causes of graft failure by period following transplantation.</p

Characteristics of patients displaying TCMR on indication biopsy.

<p>Microcirculation injury evident in 4 patients. None displayed circulating donor-specific HLA antibodies or C4d staining and therefore did not fulfil current criteria for ABMR. In addition to interstitial infiltrates these patients displayed the following: glomerulitis n = 1; chronic transplant glomerulopathy n = 1; chronic transplant glomerulopathy with nonadherence n = 1; glomerulitis and chronic transplant glomerulopathy with nonadherence n = 1.</p

Characteristics of patients displaying IFTA on indication biopsy.

<p>Characteristics of patients displaying IFTA on indication biopsy.</p

Demographics of 171 studies patients experiencing graft failure.

<p>Demographics of 171 studies patients experiencing graft failure.</p

Characteristics of patients not undergoing transplant biopsy proximate to graft failure.

<p>Characteristics of patients not undergoing transplant biopsy proximate to graft failure.</p

Kaplan-Meier analysis of time to all-cause mortality and renal replacement therapy in the Birmingham (A) and Northern European (B) cohort by genotype of <i>CAV1</i> SNP rs4730751.

<p>The number of patients at risk at separate time points is shown by year of follow-up. Graphic data shown to the last surviving 10% patients. p=0.022 (A) and p=0.427 (B).</p

Relative importance of diastolic parameters and their respective values for cluster separation.

<p>Data reported as: “Mean (95% CI)”.</p><p>Key: e’ lat (early diastolic velocity of the basal anterolateral LV wall on tissue doppler); mitral valve E/A (ratio of early to late mitral inflow velocities); E/e’ lat (maximum velocity of the E-wave of mitral valve inflow by the maximal anterolateral LV wall velocity of e’)</p><p>Relative importance of diastolic parameters and their respective values for cluster separation.</p