EFFICIENCY GAIN OF REDUCED RIPPLE CURRENT WITH ZVS DC-DC CONVERTER

The force era market, has indicated clear development. Be that as it may, a high voltage and productivity increase is key for the power module and PV board and for different machines. The high step –up converter in the proposed converter gives swell free information current. The full scaffold converter gives high voltage pick up. An APWM Full Bridge Boost converter are generally utilized as a part of utilization where the yield voltage is extensively higher than the info voltage. Zero Voltage Switching(ZVS )is commonly executed in the switches.ZVS APWM DC-DC Full extension converter that does not have any downsides of that different converters of this sort have, for example, entangled auxillary circuit,. increased current anxiety in the primary force switches and the heap subordinate ZVS operation. In this proposed strategy an interleaved procedure of Boost and Full Bridge converter is used..The diverse methods of operation of MOSFET has been talked about.. Besides converter has high proficiency due to delicate exchanging operation in switches. A 24V information voltage, 350V yield voltage, and 168W yield power reproduction circuit of the proposed converter has been executed and its effectiveness is up to 87.5%

Integrating transcriptomic and proteomic data for accurate assembly and annotation of genomes

© 2017 Wong et al.; Published by Cold Spring Harbor Laboratory Press. Complementing genome sequence with deep transcriptome and proteome data could enable more accurate assembly and annotation of newly sequenced genomes. Here, we provide a proof-of-concept of an integrated approach for analysis of the genome and proteome of Anopheles stephensi, which is one of the most important vectors of the malaria parasite. To achieve broad coverage of genes, we carried out transcriptome sequencing and deep proteome profiling of multiple anatomically distinct sites. Based on transcriptomic data alone, we identified and corrected 535 events of incomplete genome assembly involving 1196 scaffolds and 868 protein-coding gene models. This proteogenomic approach enabled us to add 365 genes that were missed during genome annotation and identify 917 gene correction events through discovery of 151 novel exons, 297 protein extensions, 231 exon extensions, 192 novel protein start sites, 19 novel translational frames, 28 events of joining of exons, and 76 events of joining of adjacent genes as a single gene. Incorporation of proteomic evidence allowed us to change the designation of more than 87 predicted noncoding RNAs to conventional mRNAs coded by protein-coding genes. Importantly, extension of the newly corrected genome assemblies and gene models to 15 other newly assembled Anopheline genomes led to the discovery of a large number of apparent discrepancies in assembly and annotation of these genomes. Our data provide a framework for how future genome sequencing efforts should incorporate transcriptomic and proteomic analysis in combination with simultaneous manual curation to achieve near complete assembly and accurate annotation of genomes

Effects of Cyclic Strain and Growth Factors on Vascular Smooth Muscle Cell Responses

Under physiological and pathological conditions, vascular smooth muscle cells (SMC) are exposed to different biochemical factors and biomechanical forces. Previous studies pertaining to SMC responses have not investigated the effects of both factors on SMCs. Thus, in our research we investigated the combined effects of growth factors like Bfgf (basic fibroblast growth factor), TGF-β (transforming growth factor β) and PDGF (platelet-derived growth factor) along with physiological cyclic strain on SMC responses. Physiological cyclic strain (10% strain) significantly reduced SMC proliferation compared to static controls while addition of growth factors bFGF, TGF-β or PDGF-AB had a positive influence on SMC growth compared to strain alone. Microarray analysis of SMCs exposed to these growth factors and cyclic strain showed that several bioactive genes (vascular endothelial growth factor, epidermal growth factor receptor, etc.) were altered upon exposure. Further work involving biochemical and pathological cyclic strain stimulation will help us better understand the role of cyclic strain and growth factors in vascular functions and development of vascular disorders

AM1 study of the twisted intramolecular charge transfer phenomenon in p-(N, N-dimethylamino) benzonitrile

The twisted intramolecular charge transfer phenomenon in p-(N,N-dimethylamino)benzonitrile has been studied using Austin model 1 (AM1) semi-empirical calculations. A detailed picture of the twisting process is obtained by calculation of the ground and excited state profiles as a function of twist angles. The effect of solvent on the energetics is obtained using Onsager's formulations and the results are compared with experimental and earlier theoretically calculated data

Effect of β-cyclodextrin on intramolecular charge-transfer emission of 4-aminophthalimide

Steady state and time-resolved studies on the fluorescence of 4-aminophthalimide (AP) in aqueous β-cyclodextrin (CD) solutions are reported. A blue shift of the fluorescence maximum, enhancement of the fluorescence quantum yield and increase in the lifetime of the emitting intramolecular charge-transfer state are observed on addition of CD to an aqueous solution of AP. It is suggested that the elimination of water molecules from the surrounding of the fluorescent probe, as a result of encapsulation, leads to the changes in the photophysical properties. The formation constant of the complex is estimated from the pre-exponential factors of the biexponential decay of the fluorescence and is found to agree reasonably well with that obtained from fluorescence intensity measurements

The nature of 4-aminophthalimide-cyclodextrin inclusion complexes

The complexation between 4-aminophthalimide and cycodextrin has been investigated in aqueous solution using steady-state and time-resolved fluorescence techniques. While 1:1 complex formation with α or β-cyclodextrin is evident from the presence of the isosbestic point in a absorption and analysis of fluorescence spectral data, the binding is rather weak with γ-cyclodextrin and more than one type of complex are indicated. The complexes of α- and β-cyclodextrins have been characterized through the measurement of fluorescence spectra, quantum, yields, and lifetimes. On the basis of the available experimental data and the results of AMI calculation on the probe molecule, possible structure of these complexes suggested

A study of prevalence of ocular disorders in primary school children in Warangal

Objectives: To study the prevalence of common ocular disorders in primary and upper primary school children between 5 to12years of age. To screen primary school children studying in government schools. Materials and methods: In the present study, a total of 50 government schools were visited. A total of 5000 children were examined. The materials consisted of Ophthalmic screening kit which has been used to detect the common oculardisorders in school. Results: A total of 5000 children were examined, of which 2491were boys and 2509 were girls. So males (49.82%) and females (50.06%) had an equal representation. The total male children found with visual defects were 168 and total female children found with visual defects were 195. Total number of children found with visual defects were 363. Male and female children with visual defects is 3.36% and 3.9%. Total children with visual defects in the sample is 7.26%.The prevalence rate of myopia, is 1.8%, hypermetropia 0.2%, astigmatism is 0.36%, Refractive errors is 2.36%, bitot’s Spots is 1.7%., conjunctival xerosis is 0.9%, Vitamin-A deficiency is 2.6%, squint is 0.42%, cornealopacity is 0.24%, cataracts is 0.16%, ptosis is 0.18%, amblyopia is 0.14%, keratitis is 0.3%, retinal diseases is 0.22%. The prevalence rate of other diseases is 0.64%. Conclusion: High prevalence of overall ocular morbidity and refractive errors among school students in urban South Indian area. It highlights the urgent need to implement at school level, health facility-based, cost-effective strategies, and appropriate eye careprograms targeting school children to reduce the burden of visual impairment among them