On the likelihoods of finding very metal-poor (and old) stars in the Milky Way’s disc, bulge, and halo

Recent observational studies have uncovered a small number of very metal-poor (VMP) stars with cold kinematics in the Galactic disc and bulge. However, their origins remain enigmatic. We select a total of 138 Milky Way (MW) analogues from the TNG50 cosmological simulation based on their z = 0 properties: discy morphology, stellar mass, and local environment. In order to make more predictive statements for the MW, we further limit the spatial volume coverage of stellar populations in galaxies to that targeted by the upcoming 4MOST high-resolution survey of the Galactic disc and bulge. We find that across all galaxies, ∼20 per cent of VMP ([Fe/H] < −2) stars belong to the disc, with some analogues reaching 30 per cent. About 50 ± 10 per cent of the VMP disc stars are, on average, older than 12.5 Gyr and ∼70 ± 10 per cent come from accreted satellites. A large fraction of the VMP stars belong to the halo (∼70) and have a median age of 12 Gyr. Our results with the TNG50 cosmological simulation confirm earlier findings with simulations of fewer individual galaxies, and suggest that the stellar disc of the MW is very likely to host significant amounts of very- and extremely-metal-poor stars that, although mostly of ex situ origin, can also form in situ, reinforcing the idea of the existence of a primordial Galactic disc

Galaxy and mass assembly (GAMA): The environmental impact on SFR and metallicity in galaxy groups

We present a study of the relationships and environmental dependencies between stellar mass, star formation rate, and gas metallicity for more than 700 galaxies in groups up to redshift 0.35 from the Galaxy And Mass Assembly (GAMA) survey. To identify the main drivers, our sample was analysed as a function of group-centric distance, projected galaxy number density, and stellar mass. By using control samples of more than 16 000 star-forming field galaxies and volume-limited samples, we find that the highest enhancement in SFR (0.3 dex) occurs in galaxies with the lowest local density. In contrast to previous work, our data show small enhancements of ∼0.1 dex in SFR for galaxies at the highest local densities or group-centric distances. Our data indicates quenching in SFR only for massive galaxies, suggesting that stellar mass might be the main driver of quenching processes for star forming galaxies. We can discard a morphological driven quenching, since the Sérsic index distribution for group and control galaxies are similar. The gas metallicity does not vary drastically. It increases ∼0.08 dex for galaxies at the highest local densities, and decreases for galaxies at the highest group-centric distances, in agreement with previous work. Altogether, the local density, rather than group-centric distance, shows the stronger impact in enhancing both, the SFR and gas metallicity. We applied the same methodology to galaxies from the IllustrisTNG simulations, and although we were able to reproduce the general observational trends, the differences between group and control samples only partially agree with the observations

Galaxy and mass assembly (GAMA): The environmental impact on SFR and metallicity in galaxy groups

We present a study of the relationships and environmental dependencies between stellar mass, star formation rate, and gas metallicity for more than 700 galaxies in groups up to redshift 0.35 from the Galaxy And Mass Assembly (GAMA) survey. To identify the main drivers, our sample was analysed as a function of group-centric distance, projected galaxy number density, and stellar mass. By using control samples of more than 16 000 star-forming field galaxies and volume-limited samples, we find that the highest enhancement in SFR (0.3 dex) occurs in galaxies with the lowest local density. In contrast to previous work, our data show small enhancements of ∼0.1 dex in SFR for galaxies at the highest local densities or group-centric distances. Our data indicates quenching in SFR only for massive galaxies, suggesting that stellar mass might be the main driver of quenching processes for star forming galaxies. We can discard a morphological driven quenching, since the Sérsic index distribution for group and control galaxies are similar. The gas metallicity does not vary drastically. It increases ∼0.08 dex for galaxies at the highest local densities, and decreases for galaxies at the highest group-centric distances, in agreement with previous work. Altogether, the local density, rather than group-centric distance, shows the stronger impact in enhancing both, the SFR and gas metallicity. We applied the same methodology to galaxies from the IllustrisTNG simulations, and although we were able to reproduce the general observational trends, the differences between group and control samples only partially agree with the observations

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies

Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference -1·69 [-9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H2O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52-23·52]; p&lt;0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75-0·86]; p&lt;0·0001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status