Intestinal Infarctus following Dilatation and Uterine Curettage

We present a case of intestinal infarctus through the vagina. This was a consequence of induced abortion done clandestinely. The main objective was to point out the surgical complications of uterine dilatation and curettage by means of this rare case

Evaluation of the single platform Muse® Auto CD4/CD4 % system in Cameroon

Background: according to who revised guidelines for scaling up antiretroviral therapy (ART) in adults and children living in resource-limited settings, there is an urgent need for laboratory monitoring, including the numeration of CD4 T cells.Objective: the study compared the muse® auto CD4/CD4% System for CD4 t cell enumeration in absolute counts and in percentages, to the Guava® AutoD4/CD4% System.Design: This was a prospective study using adults, adolescents, children and infant’s samples.Setting: The Centre International de Diagnostic Medical (CIDM), Yaounde, a research laboratory devoted to HIV screening and monitoring affiliated to the University of Yaounde I.Subjects: K3-EDTA-blood samples from 111 patients (77 adults, 12 adolescents, 18 children and 4 infants) were collected and tested. All participants signed an informed consent form whereas the guardian and parent of children signed the assent form.Results: the absolute CD4 t lymphocyte counts as well as the percentage CD4 lymphocyte of the Muse® AutoCD4/CD4% and GuavaAutoCD4/CD4% Systems, were highly correlated with an interclass correlation coefficient of 0.997 (95%CI: 0.996-0.998) and 0.991 (95% CI: 0.987-0.994) respectively. The Bland-Altman analysis limits of agreement were -5.79 cells/μl (95%CI: [-97.77; 86.19]) for the absolute CD4 T lymphocyte counts and -1.93 (95%CI: [-7.29; – 3.43]) for CD4 T lymphocyte percentage. The numbers of outliers were similar (6/111=5.41%) both for CD4 T lymphocyte counts and percentage. In addition, Cohen’s Kappa ranged from 0.95 to 1 according to CD4 T lymphocyte counts thresholds (p<0.001), showing agreement between both methods. Conclusion: this study demonstrates that the muse™ auto CD4/CD4% system constitutes a promising system for CD4 t cell counting comparable to existing reference methods, and should facilitate wider access to CD4 T cell enumeration for adults and children with HIV infection living in resource-limited countries

Ostéo-onycho-dystrophie héréditaire chez l’enfant à propos d’un cas : intérêt diagnostique.

L’ostéo-onycho-dystrophie héréditaire (OODH) est une maladie héréditaire autosomique dominante traduisant une mutation du gène LMX1B et peu de cas ont été décrits dans la littérature. Le but de ce travail était d’ajouter ce cas rare au registre de la littérature mondiale. Les auteurs rapportent un cas vraisemblable d’osteo-onycho-dystrophie héréditaire chez un petit enfant de 3 ans avec hérédité d’onycho- dystrophie maternelle, présentant une agénésie bilatérale des rotules, un trouble de la migration testiculaire mais aucune anomalie unguéale ni atteinte rénale. La littérature est révisée. Le diagnostic d’ostéo-onycho-dystrophie héréditaire repose sur un faisceau d’arguments au premier rang desquels la mutation du gène LMX1B. On comprend mieux les difficultés diagnostiques de tels cas dans nos contrées sous-médicalisées où le bilan génétique n’est pas encore entré dans les moeurs.Mots-clés : Ostéo-onycho-dystrophie, hérédité, enfant, Yaoundé, Cameroun.English AbstractContextHeditary osteo-onychodystroplasia HOOD is an autosomal dominant heriditary disease due to a mutation of the LMX1B gene and only a few cases have been described in litterature.ObjectiveThe aim of our work was to add this rare cas to the world literature register.Cas reportSome authors report one similar cas of heriditary osteo-onychodystroplasia in a 3 years child with famillial maternal onycho-dystroplasia presenting with bilateral patella agenesis, anomaly of testicular migration ,but no nail nor renal involvement was observed. Literature was reviewed.Discussion-ConclusionThe diagnosis of heriditary osteo-onychodysplasia replies on a group of argument with mutation in LMX1B gene being at the forefront. We can then understand the diagnostic difficulties of such cases in under medicalised countries where genotypic workups are not yet routinely done.Keywords: Ostéo-onychodystroplasia, heredity, child, Yaounde, Cameroo