STUDYING TO PROTECT AND MANAGE ENVIRONMENT IN MATARAM TOWN

In Environment and room design are two things are different but it has iteralated each other room designing is the instrument for all development the activities which is affiaring of over on mean that is very high risk lately. Indonesian government through the institution No. 32 in 2009,  that is about PPLH was included the principle of international agreement,  beside that the institution No. 26  in 2007 about room designing which have a lot of contribution on room designing that it could be avoided the environment crush,  the local rules No. 12 in 2011 about RT, RW of Mataram town as the key of the room designing implementation with the theoretically must  be synchronised with the both of institution above. Beside that the local rules of RT, RW Mataram town must be harmonized with local rules which the related to the local rules of the environments formula of the problem which is proposed are: 1. How are the synchronised and harmonizations between local rules of RTRW Mataram town with UUPLH and Mataram town rules environment. 2. How is implementation of local rules of RTRW Mataram town particularly related to environments. This research is used normative-empiric approaches. This research ued turn (Stufen bau Theory),  autority theory,  low invorsment theory,  normally theory and effectively theory and also supported by material low citizen and welfare theory. Based on the analyses,  researcher concluded that there is existent in insincronisation between local rules no 12 in 2011 about RTRW Mataram town with the local rules No. 3 in 2010 about RTRW west Nusa Tenggara province on RT H. Also between local rules No. 5 in 2014 about UKL/UPL were disharmony. Otherwise if it is reviewed intensively between local rules RTRW of  Mataram town with the institution No. 32 in 2009 about PPLH and institution No. 26 in 2007 about room designing  were existed synchronized of all principle,  purposes philosophy and disubstancial of rules. Means while,  the implementation of local rules of RTRW Mataram town can be concluded a part of local rules was implemented. It was accurate because there is no local rules on RDTRK. The government of Mataram town is just now meet the target of RTH about 1.606, 51 hectare or about 26.86 percent from 1.839 hectar (30%). In order to meet the target the government of Mataram town do some programs such as “green cityâ€,  etc.Key Words: Protection and Managing of Environment,  Room Designing Mataram Town

B-Raf-Mutated Melanoma

Until fairly recently, treatment options for advanced melanoma have been relatively limited. Fortunately, the last decade has seen dramatic improvements in response rates and duration of overall survival after the introduction of checkpoint inhibitors and targeted therapies against mutations in the B-isoform of Raf (B-Raf) in metastatic or inoperable melanoma. This book chapter will discuss the role of wild type B-Raf in the cell, the changes induced by mutations in this protein, and current FDA approvals for targeted therapies against B-Raf, both as a monotherapy and in combination with MEK inhibitors. We will also summarize mechanisms of resistance against these targeted therapies as well as novel therapeutic regimens proposed to bypass resistance

STUDYING TO PROTECT AND MANAGE ENVIRONMENT IN MATARAM TOWN

In Environment and room design are two things are different but it has iteralated each other room designing is the instrument for all development the activities which is affiaring of over on mean that is very high risk lately. Indonesian government through the institution No. 32 in 2009,  that is about PPLH was included the principle of international agreement,  beside that the institution No. 26  in 2007 about room designing which have a lot of contribution on room designing that it could be avoided the environment crush,  the local rules No. 12 in 2011 about RT, RW of Mataram town as the key of the room designing implementation with the theoretically must  be synchronised with the both of institution above. Beside that the local rules of RT, RW Mataram town must be harmonized with local rules which the related to the local rules of the environments formula of the problem which is proposed are: 1. How are the synchronised and harmonizations between local rules of RTRW Mataram town with UUPLH and Mataram town rules environment. 2. How is implementation of local rules of RTRW Mataram town particularly related to environments. This research is used normative-empiric approaches. This research ued turn (Stufen bau Theory),  autority theory,  low invorsment theory,  normally theory and effectively theory and also supported by material low citizen and welfare theory. Based on the analyses,  researcher concluded that there is existent in insincronisation between local rules no 12 in 2011 about RTRW Mataram town with the local rules No. 3 in 2010 about RTRW west Nusa Tenggara province on RT H. Also between local rules No. 5 in 2014 about UKL/UPL were disharmony. Otherwise if it is reviewed intensively between local rules RTRW of  Mataram town with the institution No. 32 in 2009 about PPLH and institution No. 26 in 2007 about room designing  were existed synchronized of all principle,  purposes philosophy and disubstancial of rules. Means while,  the implementation of local rules of RTRW Mataram town can be concluded a part of local rules was implemented. It was accurate because there is no local rules on RDTRK. The government of Mataram town is just now meet the target of RTH about 1.606, 51 hectare or about 26.86 percent from 1.839 hectar (30%). In order to meet the target the government of Mataram town do some programs such as “green city”,  etc.Key Words: Protection and Managing of Environment,  Room Designing Mataram Town

Transmission matrix of a uniaxial optically active crystal platelet

Expressions corresponding to the transmission of a uniaxial optically active crystal platelet are provided for an optical axis parallel and perpendicular to the plane of interface. The optical activity is taken into account by a consistent multipolar expansion of the crystal medium response due to the path of an electromagnetic wave. Numerical examples of the effect of the optical activity are given for quartz platelets of chosen thicknesses. The optical activity's effects on the variations of the transmission of quartz platelets as a function of the angle of incidence is also investigated.Comment: 18 pages, 12 figures. Accepted to Optics Communications Journa

A phase I dose-escalation study of TAK-733, an investigational oral MEK inhibitor, in patients with advanced solid tumors.

Purpose TAK-733, an investigational, selective, allosteric MEK1/2 inhibitor, has demonstrated antitumor effects against multiple cancer cell lines and xenograft models. This first-in-human study investigated TAK-733 in patients with solid tumors. Methods Patients received oral TAK-733 once daily on days 1-21 in 28-day treatment cycles. Adverse events (AEs) were graded using the Common Terminology Criteria for AEs version 3.0. Response was assessed using RECIST v1.1. Blood samples for TAK-733 pharmacokinetics and pharmacodynamics (inhibition of ERK phosphorylation) were collected during cycle 1. Results Fifty-one patients received TAK-733 0.2-22 mg. Primary diagnoses included uveal melanoma (24 %), colon cancer (22 %), and cutaneous melanoma (10 %). Four patients had dose-limiting toxicities of dermatitis acneiform, plus fatigue and pustular rash in one patient, and stomatitis in one patient. The maximum tolerated dose was 16 mg. Common drug-related AEs included dermatitis acneiform (51 %), diarrhea (29 %), and increased blood creatine phosphokinase (20 %); grade ≥ 3 AEs were reported in 27 (53 %) patients. Median Tmax was 3 h; systemic exposure increased less than dose-proportionally over the dose range 0.2-22 mg. On day 21 maximum inhibition of ERK phosphorylation in peripheral blood mononuclear cells of 46-97 % was seen in patients receiving TAK-733 ≥ 8.4 mg. Among 41 response-evaluable patients, 2 (5 %) patients with cutaneous melanoma (one with BRAF L597R mutant melanoma) had partial responses. Conclusions TAK-733 had a generally manageable toxicity profile up to the maximum tolerated dose, and showed the anticipated pharmacodynamic effect of sustained inhibition of ERK phosphorylation. Limited antitumor activity was demonstrated. Further investigation is not currently planned