The concept of social pharmacy

The 13th International Social Pharmacy Workshop will be held in Malta in July 2004. The Social Pharmacy Workshops are international conferences for research in social and behavioural pharmacy. Meetings are held every second year and participation has grown steadily since the first Workshop was held in Helsinki, Finland, in 1980. Following the successful 2002 conference in Sydney, Australia, the 2004 meeting in Malta will be the first one held in the Mediterranean area!peer-reviewe

Divergence-type 2+1 dissipative hydrodynamics applied to heavy-ion collisions

We apply divergence-type theory (DTT) dissipative hydrodynamics to study the 2+1 space-time evolution of the fireball created in Au+Au relativistic heavy-ion collisions at $\sqrt{s_{NN}}=$200 GeV. DTTs are exact hydrodynamic theories that do no rely on velocity gradient expansions and therefore go beyond second-order theories. We numerically solve the equations of motion of the DTT for Glauber initial conditions and compare the results with those of second-order theory based on conformal invariants (BRSS) and with data. We find that the charged-hadron minumum-bias elliptic flow reaches its maximum value at lower $p_T$ in the DTT, and that the DTT allows for a value of $\eta/s$ slightly larger than that of the BRSS. Our results show that the differences between viscous hydrodynamic formalisms are a significant source of uncertainty in the precise extraction of $\eta/s$ from experiments.Comment: v4: 29 pages, 12 figures, minor changes. Final version as published in Phys. Rev.

Clustered bottlenecks in mRNA translation and protein synthesis

We construct an algorithm that generates large, band-diagonal transition matrices for a totally asymmetric exclusion process (TASEP) with local hopping rate inhomogeneities. The matrices are diagonalized numerically to find steady-state currents of TASEPs with local variations in hopping rate. The results are then used to investigate clustering of slow codons along mRNA. Ribosome density profiles near neighboring clusters of slow codons interact, enhancing suppression of ribosome throughput when such bottlenecks are closely spaced. Increasing the slow codon cluster size, beyond $\approx 3-4$, does not significantly reduce ribosome current. Our results are verified by extensive Monte-Carlo simulations and provide a biologically-motivated explanation for the experimentally-observed clustering of low-usage codons

Tunable few electron quantum dots in InAs nanowires

Quantum dots realized in InAs are versatile systems to study the effect of spin-orbit interaction on the spin coherence, as well as the possibility to manipulate single spins using an electric field. We present transport measurements on quantum dots realized in InAs nanowires. Lithographically defined top-gates are used to locally deplete the nanowire and to form tunneling barriers. By using three gates, we can form either single quantum dots, or two quantum dots in series along the nanowire. Measurements of the stability diagrams for both cases show that this method is suitable for producing high quality quantum dots in InAs.Comment: 8 pages, 4 figure

Disorder-induced magnetic memory: Experiments and theories

Beautiful theories of magnetic hysteresis based on random microscopic disorder have been developed over the past ten years. Our goal was to directly compare these theories with precise experiments. We first developed and then applied coherent x-ray speckle metrology to a series of thin multilayer perpendicular magnetic materials. To directly observe the effects of disorder, we deliberately introduced increasing degrees of disorder into our films. We used coherent x-rays to generate highly speckled magnetic scattering patterns. The apparently random arrangement of the speckles is due to the exact configuration of the magnetic domains in the sample. In effect, each speckle pattern acts as a unique fingerprint for the magnetic domain configuration. Small changes in the domain structure change the speckles, and comparison of the different speckle patterns provides a quantitative determination of how much the domain structure has changed. How is the magnetic domain configuration at one point on the major hysteresis loop related to the configurations at the same point on the loop during subsequent cycles? The microscopic return-point memory(RPM) is partial and imperfect in the disordered samples, and completely absent when the disorder was not present. We found the complementary-point memory(CPM) is also partial and imperfect in the disordered samples and completely absent when the disorder was not present. We found that the RPM is always a little larger than the CPM. We also studied the correlations between the domains within a single ascending or descending loop. We developed new theoretical models that do fit our experiments.Comment: 26 pages, 25 figures, Accepted by Physical Review B 01/25/0

Fixed Point of the Finite System DMRG

The density matrix renormalization group (DMRG) is a numerical method that optimizes a variational state expressed by a tensor product. We show that the ground state is not fully optimized as far as we use the standard finite system algorithm, that uses the block structure B**B. This is because the tensors are not improved directly. We overcome this problem by using the simpler block structure B*B for the final several sweeps in the finite iteration process. It is possible to increase the numerical precision of the finite system algorithm without increasing the computational effort.Comment: 6 pages, 4 figure

Low temperature spin diffusion in the one-dimensional quantum O(3)O(3) nonlinear σ\sigma-model

An effective, low temperature, classical model for spin transport in the one-dimensional, gapped, quantum $O(3)$ non-linear $\sigma$-model is developed. Its correlators are obtained by a mapping to a model solved earlier by Jepsen. We obtain universal functions for the ballistic-to-diffusive crossover and the value of the spin diffusion constant, and these are claimed to be exact at low temperatures. Implications for experiments on one-dimensional insulators with a spin gap are noted.Comment: 4 pages including 3 eps-figures, Revte