3 research outputs found
Igniting Fitness Possibilities: a case study of an inclusive community-based physical literacy program for children and youth
Widespread concerns about lack of inclusive physical activity
programs for children and youth with medical conditions and
disabilities prompted our research team to partner with stakeholders
to develop a community-based initiative called
Igniting Fitness Possibilities (IFP). This case study describes
the systematic process and experiences of our research team
and community partners in developing and implementing IFP.
Key results from the session evaluations within the first three
IFP pilots are shared to illustrate how this implementation
evaluation guided program refinement. Overall, positive evaluations
were received from the children, youth and staff
related to the content and delivery of the IFP curricula across
the three pilots. Many of the implementation strategies mentioned
by staff to be successful aligned with the underlying
conceptual framework of the IFP program (e.g. emphasis of
teamwork and âfunâ). Suggested program modifications were
minimal and primarily focused on adaptations made to the
equipment, instruction style and/or rules.This work was supported through the National Bank, Milos Raonic Foundation Chillinâ
For Kids and the Ontario Sport and Recreation Community Fund
Perspectives on ENCODE
The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.11Nsciescopu
Expanded encyclopaedias of DNA elements in the human and mouse genomes
AbstractThe human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the Encyclopedia of DNA Elements (ENCODE) Project has expanded analysis of the cell and tissue repertoires of RNA transcription, chromatin structure and modification, DNA methylation, chromatin looping, and occupancy by transcription factors and RNA-binding proteins. Here we summarize these efforts, which have produced 5,992 new experimental datasets, including systematic determinations across mouse fetal development. All data are available through the ENCODE data portal (https://www.encodeproject.org), including phase II ENCODE1 and Roadmap Epigenomics2 data. We have developed a registry of 926,535 human and 339,815 mouse candidate cis-regulatory elements, covering 7.9 and 3.4% of their respective genomes, by integrating selected datatypes associated with gene regulation, and constructed a web-based server (SCREEN; http://screen.encodeproject.org) to provide flexible, user-defined access to this resource. Collectively, the ENCODE data and registry provide an expansive resource for the scientific community to build a better understanding of the organization and function of the human and mouse genomes.11Nsciescopu