Additional file 1 of Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A

Additional file 1: Fig. S1. 11C-UCB-J activity curves in putamen (closed circles) with model fits (solid curves). a and b Displacement (LEV, 1500 mg at 60 min) and post-dose scans, c and d displacement (BRV, 200 mg at 60 min) and post-dose scans. CND(t) and CS(t) was displayed in the dotted curves and break curves, respectively. Fig. S2. 11C-UCB-J activity curves in cerebellum (closed circles) with model fits (solid curves). a and b displacement (LEV, 1500 mg at 60 min) and post-dose scans, c and d displacement (BRV, 200 mg at 60 min) and post-dose scans. CND(t) and CS(t) was displayed in the dotted curves and break curves, respectively. Fig. S3. Concentrations of AED in the plasma and non-displaceable AED in the putamen (DND(t)) and occupancy curves by LEV (a, b) and BRV (c, d). Insets in (b) and (d) show the occupancy curves for the first 2 h. Fig. S4. Concentrations of AED in the plasma and non-displaceable AED in the cerebellum (DND(t)) and occupancy curves by LEV (a, b) and BRV (c, d). Insets in (b) and (d) show the occupancy curves for the first 2 h. Table S1. Kinetic parameters estimated using the one-tissue compartment model (LEV: n = 4, BRV: n = 5)